SAMHD1: Recurring roles in cell cycle, viral restriction, cancer, and innate immunity
Sterile alpha motif and histidine-aspartic acid domain-containing protein 1 (SAMHD1) is a deoxynucleotide triphosphate (dNTP) hydrolase that plays an important role in the homeostatic balance of cellular dNTPs. Its emerging role as an effector of innate immunity is affirmed by mutations in the SAMHD...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2018-04-01
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| Series: | Autoimmunity |
| Subjects: | |
| Online Access: | http://dx.doi.org/10.1080/08916934.2018.1454912 |
| _version_ | 1797684713887891456 |
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| author | Christopher H. Mauney Thomas Hollis |
| author_facet | Christopher H. Mauney Thomas Hollis |
| author_sort | Christopher H. Mauney |
| collection | DOAJ |
| description | Sterile alpha motif and histidine-aspartic acid domain-containing protein 1 (SAMHD1) is a deoxynucleotide triphosphate (dNTP) hydrolase that plays an important role in the homeostatic balance of cellular dNTPs. Its emerging role as an effector of innate immunity is affirmed by mutations in the SAMHD1 gene that cause the severe autoimmune disease, Aicardi–Goutieres syndrome (AGS) and that are linked to cancer. Additionally, SAMHD1 functions as a restriction factor for retroviruses, such as HIV. Here, we review the current biochemical and biological properties of the enzyme including its structure, activity, and regulation by post-translational modifications in the context of its cellular function. We outline open questions regarding the biology of SAMHD1 whose answers will be important for understanding its function as a regulator of cell cycle progression, genomic integrity, and in autoimmunity. |
| first_indexed | 2024-03-12T00:34:43Z |
| format | Article |
| id | doaj.art-01c3bf19667442cdb546ef7e4a29bb39 |
| institution | Directory Open Access Journal |
| issn | 0891-6934 1607-842X |
| language | English |
| last_indexed | 2024-03-12T00:34:43Z |
| publishDate | 2018-04-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Autoimmunity |
| spelling | doaj.art-01c3bf19667442cdb546ef7e4a29bb392023-09-15T10:01:07ZengTaylor & Francis GroupAutoimmunity0891-69341607-842X2018-04-015139611010.1080/08916934.2018.14549121454912SAMHD1: Recurring roles in cell cycle, viral restriction, cancer, and innate immunityChristopher H. Mauney0Thomas Hollis1Center for Structural Biology, Wake Forest School of MedicineCenter for Structural Biology, Wake Forest School of MedicineSterile alpha motif and histidine-aspartic acid domain-containing protein 1 (SAMHD1) is a deoxynucleotide triphosphate (dNTP) hydrolase that plays an important role in the homeostatic balance of cellular dNTPs. Its emerging role as an effector of innate immunity is affirmed by mutations in the SAMHD1 gene that cause the severe autoimmune disease, Aicardi–Goutieres syndrome (AGS) and that are linked to cancer. Additionally, SAMHD1 functions as a restriction factor for retroviruses, such as HIV. Here, we review the current biochemical and biological properties of the enzyme including its structure, activity, and regulation by post-translational modifications in the context of its cellular function. We outline open questions regarding the biology of SAMHD1 whose answers will be important for understanding its function as a regulator of cell cycle progression, genomic integrity, and in autoimmunity.http://dx.doi.org/10.1080/08916934.2018.1454912samhd1dntp metabolismnucleotideautoimmune diseaseaicardi–goutieres syndromehiv |
| spellingShingle | Christopher H. Mauney Thomas Hollis SAMHD1: Recurring roles in cell cycle, viral restriction, cancer, and innate immunity Autoimmunity samhd1 dntp metabolism nucleotide autoimmune disease aicardi–goutieres syndrome hiv |
| title | SAMHD1: Recurring roles in cell cycle, viral restriction, cancer, and innate immunity |
| title_full | SAMHD1: Recurring roles in cell cycle, viral restriction, cancer, and innate immunity |
| title_fullStr | SAMHD1: Recurring roles in cell cycle, viral restriction, cancer, and innate immunity |
| title_full_unstemmed | SAMHD1: Recurring roles in cell cycle, viral restriction, cancer, and innate immunity |
| title_short | SAMHD1: Recurring roles in cell cycle, viral restriction, cancer, and innate immunity |
| title_sort | samhd1 recurring roles in cell cycle viral restriction cancer and innate immunity |
| topic | samhd1 dntp metabolism nucleotide autoimmune disease aicardi–goutieres syndrome hiv |
| url | http://dx.doi.org/10.1080/08916934.2018.1454912 |
| work_keys_str_mv | AT christopherhmauney samhd1recurringrolesincellcycleviralrestrictioncancerandinnateimmunity AT thomashollis samhd1recurringrolesincellcycleviralrestrictioncancerandinnateimmunity |