Iguratimod, an allosteric inhibitor of macrophage migration inhibitory factor (MIF), prevents mortality and oxidative stress in a murine model of acetaminophen overdose

Iguratimod, an allosteric inhibitor of macrophage migration inhibitory factor (MIF), prevents mortality and oxidative stress in a murine model of acetaminophen overdose

Abstract Background Macrophage migration inhibitory factor (MIF) is a pleiotropic cytokine that has been implicated in multiple inflammatory and non-inflammatory diseases, including liver injury induced by acetaminophen (APAP) overdose. Multiple small molecule inhibitors of MIF have been described,...

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Bibliographic Details
Main Authors: Joshua Bloom, Georgios Pantouris, Mingzhu He, Bayan Aljabari, Lopa Mishra, Ramu Manjula, Andrew Parkins, Elias J. Lolis, Yousef Al-Abed
Format: Article
Language:English
Published: BMC 2024-03-01
Series:Molecular Medicine
Subjects:
MIF
Iguratimod
Acetaminophen
Enzyme
Drug screening
Inflammation
Online Access:https://doi.org/10.1186/s10020-024-00803-0

Internet

https://doi.org/10.1186/s10020-024-00803-0

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