Evaluation of the galactogogue effect of silymarin on mothers of preterm newborns (<32 weeks)
Hypogalactia has a relative high frequency in women having delivered preterm infants, who often have difficulties in maintaining a sufficient production of milk for their infants’ needs over prolonged periods of time. Recent studies have shown a potential galactogogue effect of silymarin on milk pro...
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| Format: | Article |
| Language: | English |
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PAGEPress Publications
2015-12-01
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| Series: | La Pediatria Medica e Chirurgica |
| Subjects: | |
| Online Access: | http://www.pediatrmedchir.org/index.php/pmc/article/view/105 |
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| author | Chiara Peila Alessandra Coscia Paola Tonetto Elena Spada Silvano Milani Guido Moro Carlotta Fontana Liliana Vagliano Claudia Tortone Elisa Di Bella Enrico Bertino |
| author_facet | Chiara Peila Alessandra Coscia Paola Tonetto Elena Spada Silvano Milani Guido Moro Carlotta Fontana Liliana Vagliano Claudia Tortone Elisa Di Bella Enrico Bertino |
| author_sort | Chiara Peila |
| collection | DOAJ |
| description | Hypogalactia has a relative high frequency in women having delivered preterm infants, who often have difficulties in maintaining a sufficient production of milk for their infants’ needs over prolonged periods of time. Recent studies have shown a potential galactogogue effect of silymarin on milk production in animal models (cows and rats) and in humans (mothers of term newborns); nonetheless, none of the studies conducted on humans consisted of double-blind randomized clinical trials and no data are available concerning mothers who delivered preterm infants. The aim of our study was to assess the efficacy of silymarin (BIO-C®) as galactogogue and its tolerability in mothers who delivered preterm infants. We enrolled 50 mothers at 10±1 days post-partum who had delivered infants at ® and placebo arms. No adverse events were observed in the 2 arms among mothers and infants, and silymarin and its metabolites were not detectable in the analyzed human milk samples. Further investigation on specific patient groups affected by hypogalactia, defined according to stricter criteria, should be planned to assess the efficacy of the product in increasing milk production. |
| first_indexed | 2024-12-23T13:33:27Z |
| format | Article |
| id | doaj.art-01c52fd673f34f82b4ea900fe40ed230 |
| institution | Directory Open Access Journal |
| issn | 0391-5387 2420-7748 |
| language | English |
| last_indexed | 2024-12-23T13:33:27Z |
| publishDate | 2015-12-01 |
| publisher | PAGEPress Publications |
| record_format | Article |
| series | La Pediatria Medica e Chirurgica |
| spelling | doaj.art-01c52fd673f34f82b4ea900fe40ed2302022-12-21T17:45:04ZengPAGEPress PublicationsLa Pediatria Medica e Chirurgica0391-53872420-77482015-12-0137310.4081/pmc.2015.105114Evaluation of the galactogogue effect of silymarin on mothers of preterm newborns (<32 weeks)Chiara Peila0Alessandra Coscia1Paola Tonetto2Elena Spada3Silvano Milani4Guido Moro5Carlotta Fontana6Liliana Vagliano7Claudia Tortone8Elisa Di Bella9Enrico Bertino10Neonatology Unit, Department of Public Health and Pediatrics, University of Turin, TurinNeonatology Unit, Department of Public Health and Pediatrics, University of Turin, TurinNeonatology Unit, Department of Public Health and Pediatrics, University of Turin, TurinUnit of Medical Statistics and Biometry, Department of Clinical Sciences and Community Health, University of Milan, MilanUnit of Medical Statistics and Biometry, Department of Clinical Sciences and Community Health, University of Milan, MilanItalian Association of Human Milk Banks, MilanNeonatology Unit, Department of Public Health and Pediatrics, University of Turin, TurinNeonatology Unit, Department of Public Health and Pediatrics, University of Turin, TurinNeonatology Unit, Department of Public Health and Pediatrics, University of Turin, TurinNeonatology Unit, Department of Public Health and Pediatrics, University of Turin, TurinNeonatology Unit, Department of Public Health and Pediatrics, University of Turin, TurinHypogalactia has a relative high frequency in women having delivered preterm infants, who often have difficulties in maintaining a sufficient production of milk for their infants’ needs over prolonged periods of time. Recent studies have shown a potential galactogogue effect of silymarin on milk production in animal models (cows and rats) and in humans (mothers of term newborns); nonetheless, none of the studies conducted on humans consisted of double-blind randomized clinical trials and no data are available concerning mothers who delivered preterm infants. The aim of our study was to assess the efficacy of silymarin (BIO-C®) as galactogogue and its tolerability in mothers who delivered preterm infants. We enrolled 50 mothers at 10±1 days post-partum who had delivered infants at ® and placebo arms. No adverse events were observed in the 2 arms among mothers and infants, and silymarin and its metabolites were not detectable in the analyzed human milk samples. Further investigation on specific patient groups affected by hypogalactia, defined according to stricter criteria, should be planned to assess the efficacy of the product in increasing milk production.http://www.pediatrmedchir.org/index.php/pmc/article/view/105Human milkGalactogoguesPreterm newbornBreastfeeding |
| spellingShingle | Chiara Peila Alessandra Coscia Paola Tonetto Elena Spada Silvano Milani Guido Moro Carlotta Fontana Liliana Vagliano Claudia Tortone Elisa Di Bella Enrico Bertino Evaluation of the galactogogue effect of silymarin on mothers of preterm newborns (<32 weeks) La Pediatria Medica e Chirurgica Human milk Galactogogues Preterm newborn Breastfeeding |
| title | Evaluation of the galactogogue effect of silymarin on mothers of preterm newborns (<32 weeks) |
| title_full | Evaluation of the galactogogue effect of silymarin on mothers of preterm newborns (<32 weeks) |
| title_fullStr | Evaluation of the galactogogue effect of silymarin on mothers of preterm newborns (<32 weeks) |
| title_full_unstemmed | Evaluation of the galactogogue effect of silymarin on mothers of preterm newborns (<32 weeks) |
| title_short | Evaluation of the galactogogue effect of silymarin on mothers of preterm newborns (<32 weeks) |
| title_sort | evaluation of the galactogogue effect of silymarin on mothers of preterm newborns 32 weeks |
| topic | Human milk Galactogogues Preterm newborn Breastfeeding |
| url | http://www.pediatrmedchir.org/index.php/pmc/article/view/105 |
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