Investigation on the Effect of 7% Chamomile Extract on Cutaneous Side Effects of Minoxidil in Treatment of Male Androgenetic Alopecia
Background and Aim Male Androgenic Alopecia (MAA) is one of the most common causes of hair loss in men. Minoxidil solution is one of the most commonly used medications for MAA treatment; however, it has several cutaneous side effects including itching, scaling and erythema, which cause the discontin...
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | fas |
| Published: |
Arak Medical University
2019-11-01
|
| Series: | Majallah-i dānishgāh-i ̒ulūm-i pizishkī-i Arāk |
| Subjects: | |
| Online Access: | http://jams.arakmu.ac.ir/article-1-6060-en.html |
| _version_ | 1811327851461345280 |
|---|---|
| author | Mina Mirnezami Bahman Sadeghi Sajid Ghadbighi Farid Sahabi Mojtaba Ahmadloo |
| author_facet | Mina Mirnezami Bahman Sadeghi Sajid Ghadbighi Farid Sahabi Mojtaba Ahmadloo |
| author_sort | Mina Mirnezami |
| collection | DOAJ |
| description | Background and Aim Male Androgenic Alopecia (MAA) is one of the most common causes of hair loss in men. Minoxidil solution is one of the most commonly used medications for MAA treatment; however, it has several cutaneous side effects including itching, scaling and erythema, which cause the discontinuation of its consumption.
Methods & Materials In this double-blind randomized clinical trial, 51 males with MAA were treated with 5% minoxidil solution and 7% chamomile extract. At the same time, 49 patients as controls were matched with this group and treated with 5% minoxidil solution alone. Both groups were treated and followed up for 6 months.
Ethical Considerations This study has received its ethical approval from the Research Ethics Committee of Arak University of Medical Sciences (code: IR.ARAKMU.REC.1395.456) and is a registered clinical trial (Code: 2017042420258N41).
Results In both groups, the severity of itching and scaling gradually decreased. in the control group, erythema increased, while in the chamomile group, erythema also decreased. All three side effects of itching, scaling and erythema were lower in the group treated with chamomile extract and minoxidil solution than in the group used minoxidil solution alone.
Conclusion It seems that simultaneous administration of 7% chamomile extract and 5% minoxidil solution leads to a reduction in the severity and duration of cutaneous side effects caused by minoxidil solution use in treatment of MAA. It can increase the patient's compliance to the treatment and eventually the chance of MAA treatment. |
| first_indexed | 2024-04-13T15:15:10Z |
| format | Article |
| id | doaj.art-01c7aff274654468a67877f95ffc88e8 |
| institution | Directory Open Access Journal |
| issn | 1735-5338 2008-644X |
| language | fas |
| last_indexed | 2024-04-13T15:15:10Z |
| publishDate | 2019-11-01 |
| publisher | Arak Medical University |
| record_format | Article |
| series | Majallah-i dānishgāh-i ̒ulūm-i pizishkī-i Arāk |
| spelling | doaj.art-01c7aff274654468a67877f95ffc88e82022-12-22T02:41:53ZfasArak Medical UniversityMajallah-i dānishgāh-i ̒ulūm-i pizishkī-i Arāk1735-53382008-644X2019-11-01225124135Investigation on the Effect of 7% Chamomile Extract on Cutaneous Side Effects of Minoxidil in Treatment of Male Androgenetic AlopeciaMina Mirnezami0Bahman Sadeghi1Sajid Ghadbighi2Farid Sahabi3Mojtaba Ahmadloo4 Department of Dermatology, School of Medicine, Arak University of Medical Sciences, Arak, Iran. Department of Social Medicine, School of Medicine, Sciences Medical of University Arak, Iran. Company Bioparticulate Tehran, Tehran, Iran. Arak Health Center, Arak, Iran. Sciences Medical of University Arak, Hospital Amiralmomenin, Center Development Research Clinical, Arak, Iran. Background and Aim Male Androgenic Alopecia (MAA) is one of the most common causes of hair loss in men. Minoxidil solution is one of the most commonly used medications for MAA treatment; however, it has several cutaneous side effects including itching, scaling and erythema, which cause the discontinuation of its consumption. Methods & Materials In this double-blind randomized clinical trial, 51 males with MAA were treated with 5% minoxidil solution and 7% chamomile extract. At the same time, 49 patients as controls were matched with this group and treated with 5% minoxidil solution alone. Both groups were treated and followed up for 6 months. Ethical Considerations This study has received its ethical approval from the Research Ethics Committee of Arak University of Medical Sciences (code: IR.ARAKMU.REC.1395.456) and is a registered clinical trial (Code: 2017042420258N41). Results In both groups, the severity of itching and scaling gradually decreased. in the control group, erythema increased, while in the chamomile group, erythema also decreased. All three side effects of itching, scaling and erythema were lower in the group treated with chamomile extract and minoxidil solution than in the group used minoxidil solution alone. Conclusion It seems that simultaneous administration of 7% chamomile extract and 5% minoxidil solution leads to a reduction in the severity and duration of cutaneous side effects caused by minoxidil solution use in treatment of MAA. It can increase the patient's compliance to the treatment and eventually the chance of MAA treatment.http://jams.arakmu.ac.ir/article-1-6060-en.htmlmale androgenic alopeciachamomile extractminoxidil solution |
| spellingShingle | Mina Mirnezami Bahman Sadeghi Sajid Ghadbighi Farid Sahabi Mojtaba Ahmadloo Investigation on the Effect of 7% Chamomile Extract on Cutaneous Side Effects of Minoxidil in Treatment of Male Androgenetic Alopecia Majallah-i dānishgāh-i ̒ulūm-i pizishkī-i Arāk male androgenic alopecia chamomile extract minoxidil solution |
| title | Investigation on the Effect of 7% Chamomile Extract on Cutaneous Side Effects of Minoxidil in Treatment of Male Androgenetic Alopecia |
| title_full | Investigation on the Effect of 7% Chamomile Extract on Cutaneous Side Effects of Minoxidil in Treatment of Male Androgenetic Alopecia |
| title_fullStr | Investigation on the Effect of 7% Chamomile Extract on Cutaneous Side Effects of Minoxidil in Treatment of Male Androgenetic Alopecia |
| title_full_unstemmed | Investigation on the Effect of 7% Chamomile Extract on Cutaneous Side Effects of Minoxidil in Treatment of Male Androgenetic Alopecia |
| title_short | Investigation on the Effect of 7% Chamomile Extract on Cutaneous Side Effects of Minoxidil in Treatment of Male Androgenetic Alopecia |
| title_sort | investigation on the effect of 7 chamomile extract on cutaneous side effects of minoxidil in treatment of male androgenetic alopecia |
| topic | male androgenic alopecia chamomile extract minoxidil solution |
| url | http://jams.arakmu.ac.ir/article-1-6060-en.html |
| work_keys_str_mv | AT minamirnezami investigationontheeffectof7chamomileextractoncutaneoussideeffectsofminoxidilintreatmentofmaleandrogeneticalopecia AT bahmansadeghi investigationontheeffectof7chamomileextractoncutaneoussideeffectsofminoxidilintreatmentofmaleandrogeneticalopecia AT sajidghadbighi investigationontheeffectof7chamomileextractoncutaneoussideeffectsofminoxidilintreatmentofmaleandrogeneticalopecia AT faridsahabi investigationontheeffectof7chamomileextractoncutaneoussideeffectsofminoxidilintreatmentofmaleandrogeneticalopecia AT mojtabaahmadloo investigationontheeffectof7chamomileextractoncutaneoussideeffectsofminoxidilintreatmentofmaleandrogeneticalopecia |