Gut microbiota-derived metabolites mediate the neuroprotective effect of melatonin in cognitive impairment induced by sleep deprivation

Gut microbiota-derived metabolites mediate the neuroprotective effect of melatonin in cognitive impairment induced by sleep deprivation

Abstract Background Sleep loss is a serious global health concern. Consequences include memory deficits and gastrointestinal dysfunction. Our previous research showed that melatonin can effectively improve cognitive impairment and intestinal microbiota disturbances caused by sleep deprivation (SD)....

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Bibliographic Details
Main Authors: Xintong Wang, Zixu Wang, Jing Cao, Yulan Dong, Yaoxing Chen
Format: Article
Language:English
Published: BMC 2023-01-01
Series:Microbiome
Subjects:
Sleep deprivation
Hippocampus
Microbial–gut–brain axis
Cognitive impairment
Melatonin
Online Access:https://doi.org/10.1186/s40168-022-01452-3

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