Novel Human Antibodies to Insulin Growth Factor 2 Receptor (IGF2R) for Radioimmunoimaging and Therapy of Canine and Human Osteosarcoma

Novel Human Antibodies to Insulin Growth Factor 2 Receptor (IGF2R) for Radioimmunoimaging and Therapy of Canine and Human Osteosarcoma

Etiological and genetic drivers of osteosarcoma (OS) are not well studied and vary from one tumor to another; making it challenging to pursue conventional targeted therapy. Recent studies have shown that cation independent mannose-6-phosphate/insulin-like growth factor-2 receptor (IGF2R) is consiste...

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Bibliographic Details
Main Authors: Jaline Broqueza, Chandra B. Prabaharan, Samitha Andrahennadi, Kevin J. H. Allen, Ryan Dickinson, Valerie MacDonald-Dickinson, Ekaterina Dadachova, Maruti Uppalapati
Format: Article
Language:English
Published: MDPI AG 2021-05-01
Series:Cancers
Subjects:
osteosarcoma
targeted radionuclide therapy
radioimmunotherapy
IGF2R
M6PR
antibody engineering
Online Access:https://www.mdpi.com/2072-6694/13/9/2208

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