Emotion causes targeted forgetting of established memories
Reconsolidation postulates that reactivation of a memory trace renders it susceptible to disruption by treatments similar to those that impair initial memory consolidation. Despite evidence that implicit, or non-declarative, human memories can be disrupted at retrieval, a convincing demonstration of...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2010-11-01
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| Series: | Frontiers in Behavioral Neuroscience |
| Subjects: | |
| Online Access: | http://journal.frontiersin.org/Journal/10.3389/fnbeh.2010.00175/full |
| _version_ | 1818274454475636736 |
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| author | Bryan A. Strange Bryan A. Strange Marijn C Kroes Judith Fan Raymond J Dolan |
| author_facet | Bryan A. Strange Bryan A. Strange Marijn C Kroes Judith Fan Raymond J Dolan |
| author_sort | Bryan A. Strange |
| collection | DOAJ |
| description | Reconsolidation postulates that reactivation of a memory trace renders it susceptible to disruption by treatments similar to those that impair initial memory consolidation. Despite evidence that implicit, or non-declarative, human memories can be disrupted at retrieval, a convincing demonstration of selective impairment in retrieval of target episodic memories following reactivation is lacking. In human subjects, we demonstrate that if reactivation of a verbal memory, through successful retrieval, is immediately followed by an emotionally aversive stimulus, a significant impairment is evident in its later recall. This effect is time-dependent and persists for at least six days. Thus, in line with a reconsolidation hypothesis, established human episodic memories can be selectively impaired following their retrieval. |
| first_indexed | 2024-12-12T22:14:07Z |
| format | Article |
| id | doaj.art-01ca1e8e52d04136a1d0e01aa5f3a938 |
| institution | Directory Open Access Journal |
| issn | 1662-5153 |
| language | English |
| last_indexed | 2024-12-12T22:14:07Z |
| publishDate | 2010-11-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Behavioral Neuroscience |
| spelling | doaj.art-01ca1e8e52d04136a1d0e01aa5f3a9382022-12-22T00:10:09ZengFrontiers Media S.A.Frontiers in Behavioral Neuroscience1662-51532010-11-01410.3389/fnbeh.2010.001751986Emotion causes targeted forgetting of established memoriesBryan A. Strange0Bryan A. Strange1Marijn C Kroes2Judith Fan3Raymond J Dolan4Institute of Neurology, University Colllege LondonUPM-UCMInstitute of Neurology, University Colllege LondonInstitute of Neurology, University Colllege LondonInstitute of Neurology, University Colllege LondonReconsolidation postulates that reactivation of a memory trace renders it susceptible to disruption by treatments similar to those that impair initial memory consolidation. Despite evidence that implicit, or non-declarative, human memories can be disrupted at retrieval, a convincing demonstration of selective impairment in retrieval of target episodic memories following reactivation is lacking. In human subjects, we demonstrate that if reactivation of a verbal memory, through successful retrieval, is immediately followed by an emotionally aversive stimulus, a significant impairment is evident in its later recall. This effect is time-dependent and persists for at least six days. Thus, in line with a reconsolidation hypothesis, established human episodic memories can be selectively impaired following their retrieval.http://journal.frontiersin.org/Journal/10.3389/fnbeh.2010.00175/fullemotionepisodic memoryconsolidationreconsolidationCued recallRetrograde amnesia |
| spellingShingle | Bryan A. Strange Bryan A. Strange Marijn C Kroes Judith Fan Raymond J Dolan Emotion causes targeted forgetting of established memories Frontiers in Behavioral Neuroscience emotion episodic memory consolidation reconsolidation Cued recall Retrograde amnesia |
| title | Emotion causes targeted forgetting of established memories |
| title_full | Emotion causes targeted forgetting of established memories |
| title_fullStr | Emotion causes targeted forgetting of established memories |
| title_full_unstemmed | Emotion causes targeted forgetting of established memories |
| title_short | Emotion causes targeted forgetting of established memories |
| title_sort | emotion causes targeted forgetting of established memories |
| topic | emotion episodic memory consolidation reconsolidation Cued recall Retrograde amnesia |
| url | http://journal.frontiersin.org/Journal/10.3389/fnbeh.2010.00175/full |
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