Aggressive Cutaneous Squamous Cell Carcinoma of the Head and Neck: A Review
Non-melanoma skin cancer of the head and neck (NMSCHN) is one of the most common malignancies worldwide, and its incidence is growing at a significant rate. It has been found to be aggressive in its spread and has the capacity to metastasize to regional lymph nodes. Cutaneous squamous cell carcinoma...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-07-01
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| Series: | Current Oncology |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1718-7729/30/7/487 |
| _version_ | 1797589632627507200 |
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| author | Neha Desai Mukul K. Divatia Aniket Jadhav Aditya Wagh |
| author_facet | Neha Desai Mukul K. Divatia Aniket Jadhav Aditya Wagh |
| author_sort | Neha Desai |
| collection | DOAJ |
| description | Non-melanoma skin cancer of the head and neck (NMSCHN) is one of the most common malignancies worldwide, and its incidence is growing at a significant rate. It has been found to be aggressive in its spread and has the capacity to metastasize to regional lymph nodes. Cutaneous squamous cell carcinoma (cSCC) has a considerably high mortality rate. It has remarkable characteristics: diameter >2 cm, depth >5 mm, high recurrence, perineural invasion, and locoregional metastases. Aggressive cSCC lesions most commonly metastasize to the parotid gland. Also, immunocompromised patients have a higher risk of developing this aggressive cancer along with the worst prognostic outcomes. It is very important to discuss and assess the risk factors, prognostic factors, and outcomes of patients with cSCC, which will give clinicians future directives for making modifications to their treatment plans. The successful treatment of aggressive cSCC of the head and neck includes early detection and diagnosis, surgery alone or adjuvant chemotherapy, and radiotherapy as required. Multimodal therapy options should be considered by clinicians for better outcomes of aggressive cSCC of the head and neck. |
| first_indexed | 2024-03-11T01:09:20Z |
| format | Article |
| id | doaj.art-01cb6f639802493eacc652b3bb35a980 |
| institution | Directory Open Access Journal |
| issn | 1198-0052 1718-7729 |
| language | English |
| last_indexed | 2024-03-11T01:09:20Z |
| publishDate | 2023-07-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Current Oncology |
| spelling | doaj.art-01cb6f639802493eacc652b3bb35a9802023-11-18T18:55:57ZengMDPI AGCurrent Oncology1198-00521718-77292023-07-013076634664710.3390/curroncol30070487Aggressive Cutaneous Squamous Cell Carcinoma of the Head and Neck: A ReviewNeha Desai0Mukul K. Divatia1Aniket Jadhav2Aditya Wagh3JDC Healthcare, Houston, TX 77015, USAHouston Methodist Hospital, Houston, TX 77030, USAVCU School of Dentistry, Richmond, VA 23298, USAJDC Healthcare, Houston, TX 77034, USANon-melanoma skin cancer of the head and neck (NMSCHN) is one of the most common malignancies worldwide, and its incidence is growing at a significant rate. It has been found to be aggressive in its spread and has the capacity to metastasize to regional lymph nodes. Cutaneous squamous cell carcinoma (cSCC) has a considerably high mortality rate. It has remarkable characteristics: diameter >2 cm, depth >5 mm, high recurrence, perineural invasion, and locoregional metastases. Aggressive cSCC lesions most commonly metastasize to the parotid gland. Also, immunocompromised patients have a higher risk of developing this aggressive cancer along with the worst prognostic outcomes. It is very important to discuss and assess the risk factors, prognostic factors, and outcomes of patients with cSCC, which will give clinicians future directives for making modifications to their treatment plans. The successful treatment of aggressive cSCC of the head and neck includes early detection and diagnosis, surgery alone or adjuvant chemotherapy, and radiotherapy as required. Multimodal therapy options should be considered by clinicians for better outcomes of aggressive cSCC of the head and neck.https://www.mdpi.com/1718-7729/30/7/487aggressive cutaneous squamous cell carcinomahead and neck regionreviewnon-melanoma cancermetastatic |
| spellingShingle | Neha Desai Mukul K. Divatia Aniket Jadhav Aditya Wagh Aggressive Cutaneous Squamous Cell Carcinoma of the Head and Neck: A Review Current Oncology aggressive cutaneous squamous cell carcinoma head and neck region review non-melanoma cancer metastatic |
| title | Aggressive Cutaneous Squamous Cell Carcinoma of the Head and Neck: A Review |
| title_full | Aggressive Cutaneous Squamous Cell Carcinoma of the Head and Neck: A Review |
| title_fullStr | Aggressive Cutaneous Squamous Cell Carcinoma of the Head and Neck: A Review |
| title_full_unstemmed | Aggressive Cutaneous Squamous Cell Carcinoma of the Head and Neck: A Review |
| title_short | Aggressive Cutaneous Squamous Cell Carcinoma of the Head and Neck: A Review |
| title_sort | aggressive cutaneous squamous cell carcinoma of the head and neck a review |
| topic | aggressive cutaneous squamous cell carcinoma head and neck region review non-melanoma cancer metastatic |
| url | https://www.mdpi.com/1718-7729/30/7/487 |
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