Neonatal Respiratory Distress Secondary to Meconium Aspiration Syndrome
Infants born through meconium-stained amniotic fluid (MSAF) are 100 times more likely than infants born through clear amniotic fluid to develop respiratory distress in the neonatal period. Meconium aspiration syndrome (MAS) is a common cause of respiratory distress in term and post-mature neonates....
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-03-01
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| Series: | Children |
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| Online Access: | https://www.mdpi.com/2227-9067/8/3/246 |
| _version_ | 1827696961841528832 |
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| author | Arielle L. Olicker Thomas M. Raffay Rita M. Ryan |
| author_facet | Arielle L. Olicker Thomas M. Raffay Rita M. Ryan |
| author_sort | Arielle L. Olicker |
| collection | DOAJ |
| description | Infants born through meconium-stained amniotic fluid (MSAF) are 100 times more likely than infants born through clear amniotic fluid to develop respiratory distress in the neonatal period. Meconium aspiration syndrome (MAS) is a common cause of respiratory distress in term and post-mature neonates. MAS is defined as respiratory distress accompanied by a supplemental oxygen requirement in an infant born with MSAF, in the absence of any other identified etiology to explain the symptoms. Therapy for MAS is supportive, and should be tailored to each infant’s specific pathophysiology. In cases of MAS with severe persistent pulmonary hypertension of the newborn (PPHN), patients may remain hypoxic despite aggressive ventilation, and in these cases surfactant, inhaled nitric oxide (iNO) and extracorporeal membrane oxygenation (ECMO) can be life-saving. Long-term prognosis for MAS is more related to severity of initial hypoxemia and possible neurological insult than to the pulmonary pathology. |
| first_indexed | 2024-03-10T12:59:35Z |
| format | Article |
| id | doaj.art-01cb873ba1e643d7a39017371cc6a18b |
| institution | Directory Open Access Journal |
| issn | 2227-9067 |
| language | English |
| last_indexed | 2024-03-10T12:59:35Z |
| publishDate | 2021-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Children |
| spelling | doaj.art-01cb873ba1e643d7a39017371cc6a18b2023-11-21T11:35:46ZengMDPI AGChildren2227-90672021-03-018324610.3390/children8030246Neonatal Respiratory Distress Secondary to Meconium Aspiration SyndromeArielle L. Olicker0Thomas M. Raffay1Rita M. Ryan2Department of Pediatrics, Case Western Reserve University, UH Rainbow Babies & Children’s Hospital, 11100 Euclid Ave, Cleveland, OH 44106, USADepartment of Pediatrics, Case Western Reserve University, UH Rainbow Babies & Children’s Hospital, 11100 Euclid Ave, Cleveland, OH 44106, USADepartment of Pediatrics, Case Western Reserve University, UH Rainbow Babies & Children’s Hospital, 11100 Euclid Ave, Cleveland, OH 44106, USAInfants born through meconium-stained amniotic fluid (MSAF) are 100 times more likely than infants born through clear amniotic fluid to develop respiratory distress in the neonatal period. Meconium aspiration syndrome (MAS) is a common cause of respiratory distress in term and post-mature neonates. MAS is defined as respiratory distress accompanied by a supplemental oxygen requirement in an infant born with MSAF, in the absence of any other identified etiology to explain the symptoms. Therapy for MAS is supportive, and should be tailored to each infant’s specific pathophysiology. In cases of MAS with severe persistent pulmonary hypertension of the newborn (PPHN), patients may remain hypoxic despite aggressive ventilation, and in these cases surfactant, inhaled nitric oxide (iNO) and extracorporeal membrane oxygenation (ECMO) can be life-saving. Long-term prognosis for MAS is more related to severity of initial hypoxemia and possible neurological insult than to the pulmonary pathology.https://www.mdpi.com/2227-9067/8/3/246meconium aspiration syndromerespiratory distresssurfactant |
| spellingShingle | Arielle L. Olicker Thomas M. Raffay Rita M. Ryan Neonatal Respiratory Distress Secondary to Meconium Aspiration Syndrome Children meconium aspiration syndrome respiratory distress surfactant |
| title | Neonatal Respiratory Distress Secondary to Meconium Aspiration Syndrome |
| title_full | Neonatal Respiratory Distress Secondary to Meconium Aspiration Syndrome |
| title_fullStr | Neonatal Respiratory Distress Secondary to Meconium Aspiration Syndrome |
| title_full_unstemmed | Neonatal Respiratory Distress Secondary to Meconium Aspiration Syndrome |
| title_short | Neonatal Respiratory Distress Secondary to Meconium Aspiration Syndrome |
| title_sort | neonatal respiratory distress secondary to meconium aspiration syndrome |
| topic | meconium aspiration syndrome respiratory distress surfactant |
| url | https://www.mdpi.com/2227-9067/8/3/246 |
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