Updates on the CDK4/6 Inhibitory Strategy and Combinations in Breast Cancer

Updates on the CDK4/6 Inhibitory Strategy and Combinations in Breast Cancer

Breast Cancer (BC) is the second most common type of cancer worldwide and displays the highest cancer-related mortality among women worldwide. Targeted therapies have revolutionized the way BC has been treated in recent decades, improving the life expectancies of millions of women. Among the differe...

Full description

Bibliographic Details
Main Authors:	Navid Sobhani, Alberto D’Angelo, Matteo Pittacolo, Giandomenico Roviello, Anna Miccoli, Silvia Paola Corona, Ottavia Bernocchi, Daniele Generali, Tobias Otto
Format:	Article
Language:	English
Published:	MDPI AG 2019-04-01
Series:	Cells
Subjects:	cyclin-dependent kinases cyclin-dependent kinase 4 and 6 inhibitors targeted therapies breast cancer
Online Access:	https://www.mdpi.com/2073-4409/8/4/321

Similar Items

Mouse Model of Congenital Heart Defects, Dysmorphic Facial Features and Intellectual Developmental Disorders as a Result of Non-functional CDK13
by: Monika Nováková, et al.
Published: (2019-08-01)

Sub-cloning of cyclin-dependent kinase 3 (CDK3) gene into a mammalian expression vector /
by: Alnaseri, Zubaida Talal M., 1996-, author 614711
Published: (2018)

Sub-cloning of cyclin-dependent kinase 3 (CDK3) gene into a mammalian expression vector /
by: Alnaseri, Zubaida Talal M., 1996-, author 614711, et al.
Published: (2018)

Binding selectivity-dependent molecular mechanism of inhibitors towards CDK2 and CDK6 investigated by multiple short molecular dynamics and free energy landscapes
by: Lifei Wang, et al.
Published: (2023-12-01)

Docking to a Basic Helix Promotes Specific Phosphorylation by G1-Cdk1
by: Ilona Faustova, et al.
Published: (2021-09-01)

Expression of cyclooxygenase-2(COX-2) and cyclin dependent kinase 1B (CDKN1B/p27Kip1⁯) in human prostatet adenocarcinoma
by: Md Roduan, Mohd Rohaizad
Published: (2011)

Lappaol F regulates the cell cycle by activating CDKN1C/p57 in human colorectal cancer cells
by: Rui-Yi Yang, et al.
Published: (2023-12-01)

A uniform procedure for the purification of CDK7/CycH/MAT1, CDK8/CycC and CDK9/CycT1
by: Pinhero Reena, et al.
Published: (2004-01-01)

Inhibition of Mitochondrial Antioxidant Defense and CDK4/6 in Mesothelioma
by: Marian Kratzke, et al.
Published: (2023-05-01)

Cyclin-Dependent Kinases (CDK) and Their Role in Diseases Development–Review
by: Paweł Łukasik, et al.
Published: (2021-03-01)

An In Silico Approach for Potential Natural Compounds as Inhibitors of Protein CDK1/Cks2
by: Abu Saim Mohammad Saikat
Published: (2021-11-01)

Multiple cutaneous melanomas associated with gastric and brain metastases
by: Lara Caroline Grander, et al.
Published: (2016-10-01)

Exploring cell cycle-mediated regulations of glycolysis in budding yeast
by: Yanfei Zhang, et al.
Published: (2023-10-01)

EmCyclinD-EmCDK4/6 complex is involved in the host EGF-mediated proliferation of Echinococcus multilocularis germinative cells via the EGFR-ERK pathway
by: Chonglv Feng, et al.
Published: (2022-08-01)

A paradigm shift for the treatment of hormone receptor-positive, human epidermal growth factor receptor 2-negative (HR+/HER2-) advanced breast cancer: a review of CDK inhibitors
by: Mariane Teodoro Fernandes, et al.
Published: (2018-11-01)

CDK Regulation of Meiosis: Lessons from <i>S. cerevisiae</i> and <i>S. pombe</i>
by: Anne M. MacKenzie, et al.
Published: (2020-06-01)

New Imadazopyrazines with CDK9 Inhibitory Activity as Anticancer and Antiviral: Synthesis, In Silico, and In Vitro Evaluation Approaches
by: Aisha A. Alsfouk, et al.
Published: (2023-07-01)

Cyclin B Export to the Cytoplasm via the Nup62 Subcomplex and Subsequent Rapid Nuclear Import Are Required for the Initiation of <i>Drosophila</i> Male Meiosis
by: Kanta Yamazoe, et al.
Published: (2023-11-01)

Neurogenesis and gliogenesis modulation in cerebral ischemia by CDK5 RNAi-based therapy
by: Juan Ignacio Muñoz-Manco, et al.
Published: (2018-09-01)

Systemic Administration of a Brain Permeable Cdk5 Inhibitor Alters Neurobehavior
by: Alan Umfress, et al.
Published: (2022-05-01)

Development of CDK4/6 Inhibitors: A Five Years Update
by: Alessandra Ammazzalorso, et al.
Published: (2021-03-01)

Two-way communication between cell cycle and metabolism in budding yeast: what do we know?
by: Yanfei Zhang, et al.
Published: (2023-06-01)

Il ciclo cellulare: cos'è, come è stato e come sarà studiato
by: Sara Nardi, et al.
Published: (2015-06-01)

Cdk5 Phosphorylates a Component of the HDAC Complex and Regulates Histone Acetylation during Neuronal Cell Death
by: Amy K.Y. Fu, et al.
Published: (2012-03-01)

Safety of CDK4/6 Inhibitors Combined with Radiotherapy in Patients with Metastatic Breast Cancer: A Review of the Literature
by: Rejane Franco, et al.
Published: (2023-06-01)

A review on the role of cyclin dependent kinases in cancers
by: Soudeh Ghafouri-Fard, et al.
Published: (2022-10-01)

Docosahexaenoic acid inhibits cancer cell growth via p27Kip1, CDK2, ERK1/ERK2, and retinoblastoma phosphorylation
by: Naim A. Khan, et al.
Published: (2006-10-01)

Policing Cancer: Vitamin D Arrests the Cell Cycle
by: Sachin Bhoora, et al.
Published: (2020-12-01)

Induction of apoptosis in cancer cells by tumor necrosis factor and butyrolactone, an inhibitor of cyclin-dependent kinases
by: J.E. Belizário, et al.
Published: (1999-04-01)

Explaining Redundancy in CDK-Mediated Control of the Cell Cycle: Unifying the Continuum and Quantitative Models
by: Daniel Fisher, et al.
Published: (2022-06-01)

Targeting Protein-Protein Interactions to Inhibit Cyclin-Dependent Kinases
by: Mark Klein
Published: (2023-03-01)

Restriction Checkpoint Controls Bradyzoite Development in Toxoplasma gondii
by: Anatoli V. Naumov, et al.
Published: (2022-06-01)

Cell Cycle Regulation in the Plant Response to Stress
by: Feifei Qi, et al.
Published: (2020-01-01)

CDK4/6 Inhibitors in Breast Cancer Treatment: Potential Interactions with Drug, Gene, and Pathophysiological Conditions
by: Rossana Roncato, et al.
Published: (2020-09-01)

Cyclin-dependent kinase 9 (CDK9) predicts recurrence in Middle Eastern epithelial ovarian cancer
by: Sandeep Kumar Parvathareddy, et al.
Published: (2021-05-01)

Palbociclib-mediated cell cycle arrest can occur in the absence of the CDK inhibitors p21 and p27
by: Betheney R. Pennycook, et al.
Published: (2021-11-01)

Cyclin A/Cdk1 modulates Plk1 activity in prometaphase to regulate kinetochore-microtubule attachment stability
by: Ana Maria G Dumitru, et al.
Published: (2017-11-01)

The Regulation of Cyclins and Cyclin-Dependent Kinases in the Development of Gastric Cancer
by: Aadil Javed, et al.
Published: (2023-02-01)

CDKs family -a glimpse into the past and present: from cell cycle control to current biological functions
by: Muzna Shah, et al.
Published: (2020-02-01)

Physicochemical Properties of analogs α-Aminophosphonates Drugs Determined via Molecular Dynamics Simulation
by: Reihaneh Sabbaghzadeh
Published: (2019-09-01)