A 5,000-year-old hunter-gatherer already plagued by Yersinia pestis
Summary: A 5,000-year-old Yersinia pestis genome (RV 2039) is reconstructed from a hunter-fisher-gatherer (5300–5050 cal BP) buried at Riņņukalns, Latvia. RV 2039 is the first in a series of ancient strains that evolved shortly after the split of Y. pestis from its antecessor Y. pseudotuberculosis ∼...
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| Format: | Article |
| Language: | English |
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Elsevier
2021-06-01
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| Series: | Cell Reports |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2211124721006458 |
| _version_ | 1818892590798340096 |
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| author | Julian Susat Harald Lübke Alexander Immel Ute Brinker Aija Macāne John Meadows Britta Steer Andreas Tholey Ilga Zagorska Guntis Gerhards Ulrich Schmölcke Mārcis Kalniņš Andre Franke Elīna Pētersone-Gordina Barbara Teßman Mari Tõrv Stefan Schreiber Christian Andree Valdis Bērziņš Almut Nebel Ben Krause-Kyora |
| author_facet | Julian Susat Harald Lübke Alexander Immel Ute Brinker Aija Macāne John Meadows Britta Steer Andreas Tholey Ilga Zagorska Guntis Gerhards Ulrich Schmölcke Mārcis Kalniņš Andre Franke Elīna Pētersone-Gordina Barbara Teßman Mari Tõrv Stefan Schreiber Christian Andree Valdis Bērziņš Almut Nebel Ben Krause-Kyora |
| author_sort | Julian Susat |
| collection | DOAJ |
| description | Summary: A 5,000-year-old Yersinia pestis genome (RV 2039) is reconstructed from a hunter-fisher-gatherer (5300–5050 cal BP) buried at Riņņukalns, Latvia. RV 2039 is the first in a series of ancient strains that evolved shortly after the split of Y. pestis from its antecessor Y. pseudotuberculosis ∼7,000 years ago. The genomic and phylogenetic characteristics of RV 2039 are consistent with the hypothesis that this very early Y. pestis form was most likely less transmissible and maybe even less virulent than later strains. Our data do not support the scenario of a prehistoric pneumonic plague pandemic, as suggested previously for the Neolithic decline. The geographical and temporal distribution of the few prehistoric Y. pestis cases reported so far is more in agreement with single zoonotic events. |
| first_indexed | 2024-12-19T17:59:08Z |
| format | Article |
| id | doaj.art-01cc12552ad7439981304caadd9962d3 |
| institution | Directory Open Access Journal |
| issn | 2211-1247 |
| language | English |
| last_indexed | 2024-12-19T17:59:08Z |
| publishDate | 2021-06-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Cell Reports |
| spelling | doaj.art-01cc12552ad7439981304caadd9962d32022-12-21T20:11:44ZengElsevierCell Reports2211-12472021-06-013513109278A 5,000-year-old hunter-gatherer already plagued by Yersinia pestisJulian Susat0Harald Lübke1Alexander Immel2Ute Brinker3Aija Macāne4John Meadows5Britta Steer6Andreas Tholey7Ilga Zagorska8Guntis Gerhards9Ulrich Schmölcke10Mārcis Kalniņš11Andre Franke12Elīna Pētersone-Gordina13Barbara Teßman14Mari Tõrv15Stefan Schreiber16Christian Andree17Valdis Bērziņš18Almut Nebel19Ben Krause-Kyora20Institute of Clinical Molecular Biology, Kiel University, Rosalind-Franklin-Str. 12, 24105 Kiel, GermanyCentre for Baltic and Scandinavian Archaeology (ZBSA), Schleswig-Holstein State Museums Foundation Schloss Gottorf, Schlossinsel 1, 24837 Schleswig, GermanyInstitute of Clinical Molecular Biology, Kiel University, Rosalind-Franklin-Str. 12, 24105 Kiel, GermanyCentre for Baltic and Scandinavian Archaeology (ZBSA), Schleswig-Holstein State Museums Foundation Schloss Gottorf, Schlossinsel 1, 24837 Schleswig, GermanyDepartment of Historical Studies, University of Gothenburg, PO Box 200, SE405 30 Göteborg, SwedenCentre for Baltic and Scandinavian Archaeology (ZBSA), Schleswig-Holstein State Museums Foundation Schloss Gottorf, Schlossinsel 1, 24837 Schleswig, Germany; Leibniz Laboratory for AMS Dating and Isotope Research, Kiel University, Max-Eyth-Str. 11-13, 24118 Kiel, GermanySystematic Proteomics & Bioanalytics, Institute for Experimental Medicine, Kiel University, Niemannsweg 11, 24105 Kiel, GermanySystematic Proteomics & Bioanalytics, Institute for Experimental Medicine, Kiel University, Niemannsweg 11, 24105 Kiel, GermanyInstitute of Latvian History, University of Latvia, Kalpaka bulv. 4, 1050 Riga, LatviaInstitute of Latvian History, University of Latvia, Kalpaka bulv. 4, 1050 Riga, LatviaCentre for Baltic and Scandinavian Archaeology (ZBSA), Schleswig-Holstein State Museums Foundation Schloss Gottorf, Schlossinsel 1, 24837 Schleswig, GermanyInstitute of Latvian History, University of Latvia, Kalpaka bulv. 4, 1050 Riga, LatviaInstitute of Clinical Molecular Biology, Kiel University, Rosalind-Franklin-Str. 12, 24105 Kiel, GermanyInstitute of Latvian History, University of Latvia, Kalpaka bulv. 4, 1050 Riga, LatviaBerlin Society of Anthropology, Ethnology and Prehistory, c/o Museum of Pre- and Protohistory, Geschwister-Scholl-Str. 6, 10117 Berlin, GermanyDepartment of Archaeology, Institute of History and Archaeology, University of Tartu, Jakobi 2, 51005 Tartu, EstoniaInstitute of Clinical Molecular Biology, Kiel University, Rosalind-Franklin-Str. 12, 24105 Kiel, Germany; Department of General Internal Medicine, University Hospital Schleswig-Holstein, Kiel University, Rosalind-Franklin-Str. 12, 24105 Kiel, GermanyResearch Center of Medical History, Kiel University, Breiter Weg 10, 24105 Kiel, GermanyInstitute of Latvian History, University of Latvia, Kalpaka bulv. 4, 1050 Riga, LatviaInstitute of Clinical Molecular Biology, Kiel University, Rosalind-Franklin-Str. 12, 24105 Kiel, GermanyInstitute of Clinical Molecular Biology, Kiel University, Rosalind-Franklin-Str. 12, 24105 Kiel, Germany; Corresponding authorSummary: A 5,000-year-old Yersinia pestis genome (RV 2039) is reconstructed from a hunter-fisher-gatherer (5300–5050 cal BP) buried at Riņņukalns, Latvia. RV 2039 is the first in a series of ancient strains that evolved shortly after the split of Y. pestis from its antecessor Y. pseudotuberculosis ∼7,000 years ago. The genomic and phylogenetic characteristics of RV 2039 are consistent with the hypothesis that this very early Y. pestis form was most likely less transmissible and maybe even less virulent than later strains. Our data do not support the scenario of a prehistoric pneumonic plague pandemic, as suggested previously for the Neolithic decline. The geographical and temporal distribution of the few prehistoric Y. pestis cases reported so far is more in agreement with single zoonotic events.http://www.sciencedirect.com/science/article/pii/S2211124721006458Yersinia pestisaDNAhunter-gathererzoonosis |
| spellingShingle | Julian Susat Harald Lübke Alexander Immel Ute Brinker Aija Macāne John Meadows Britta Steer Andreas Tholey Ilga Zagorska Guntis Gerhards Ulrich Schmölcke Mārcis Kalniņš Andre Franke Elīna Pētersone-Gordina Barbara Teßman Mari Tõrv Stefan Schreiber Christian Andree Valdis Bērziņš Almut Nebel Ben Krause-Kyora A 5,000-year-old hunter-gatherer already plagued by Yersinia pestis Cell Reports Yersinia pestis aDNA hunter-gatherer zoonosis |
| title | A 5,000-year-old hunter-gatherer already plagued by Yersinia pestis |
| title_full | A 5,000-year-old hunter-gatherer already plagued by Yersinia pestis |
| title_fullStr | A 5,000-year-old hunter-gatherer already plagued by Yersinia pestis |
| title_full_unstemmed | A 5,000-year-old hunter-gatherer already plagued by Yersinia pestis |
| title_short | A 5,000-year-old hunter-gatherer already plagued by Yersinia pestis |
| title_sort | 5 000 year old hunter gatherer already plagued by yersinia pestis |
| topic | Yersinia pestis aDNA hunter-gatherer zoonosis |
| url | http://www.sciencedirect.com/science/article/pii/S2211124721006458 |
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