Dual Thermo- and Photo-Responsive Micelles Based on Azobenzene-Containing Random Copolymer
Amphiphilic random copolymer poly(methacrylamido-azobenzene)-<i>ran</i>-poly(2-hydroxyethylacrylate) (PMAAAB-<i>ran</i>-PHEA) was synthesized via hydrolysis of poly(methacrylamido-azobenzene)-<i>ran</i>-poly[2-((2′-tetrahydropyranyl)oxy)ethylacrylate] (PMAAAB-<...
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2021-12-01
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| author | Chuan Yan Liqin Yang Xiangquan Mo Keying Chen Weiya Niu Zhiju Zhao Guanghua Li |
| author_facet | Chuan Yan Liqin Yang Xiangquan Mo Keying Chen Weiya Niu Zhiju Zhao Guanghua Li |
| author_sort | Chuan Yan |
| collection | DOAJ |
| description | Amphiphilic random copolymer poly(methacrylamido-azobenzene)-<i>ran</i>-poly(2-hydroxyethylacrylate) (PMAAAB-<i>ran</i>-PHEA) was synthesized via hydrolysis of poly(methacrylamido-azobenzene)-<i>ran</i>-poly[2-((2′-tetrahydropyranyl)oxy)ethylacrylate] (PMAAAB-<i>ran</i>-P(THP-HEA)), which was prepared by conventional radical polymerization. PMAAAB-<i>ran</i>-PHEA micelles were then prepared via dialysis method against water with DMF as solvent. The structure, morphology, size, and low critical solution temperature (LCST) of PMAAAB-<i>ran</i>-PHEA and its micelles were determined by <sup>1</sup>H-NMR, GPC, TEM, and DLS. The thermo- and photo-responsive behaviors of the resulting polymer micelles were investigated with Nile red as a fluorescence probe. The results showed that PMAAAB-<i>ran</i>-PHEA micelles were porous or bowl-shaped and its size was 135–150 nm, and its LCST was 55 °C when <i>F</i><sub>MAAAB</sub> of the random copolymer was 0.5351; the hydrophobicity of the micellar core was changed reversibly under the irradiation of UV light and visible light without release of Nile red or disruption of micelles; the size and solubilization capacity of the micelles were dependent on temperature, and Nile red would migrate for many times between the water phase and the micelles, and finally increasingly accumulated during the repeated heating and cooling processes. |
| first_indexed | 2024-03-10T03:35:19Z |
| format | Article |
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| institution | Directory Open Access Journal |
| issn | 1996-1944 |
| language | English |
| last_indexed | 2024-03-10T03:35:19Z |
| publishDate | 2021-12-01 |
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| series | Materials |
| spelling | doaj.art-01cde048624440cf841b99529c271dd42023-11-23T11:46:33ZengMDPI AGMaterials1996-19442021-12-01151210.3390/ma15010002Dual Thermo- and Photo-Responsive Micelles Based on Azobenzene-Containing Random CopolymerChuan Yan0Liqin Yang1Xiangquan Mo2Keying Chen3Weiya Niu4Zhiju Zhao5Guanghua Li6Guangxi Key Laboratory of Petrochemical Resource Processing & Process Intensification Technology, School of Chemistry and Chemical Engineering, Guangxi University, Nanning 530004, ChinaHebei Functional Polymer Materials R&D and Engineering Application Technology Innovation Center, College of Chemistry & Chemical Engineering, Xingtai University, Xingtai 050041, ChinaGuangxi Key Laboratory of Petrochemical Resource Processing & Process Intensification Technology, School of Chemistry and Chemical Engineering, Guangxi University, Nanning 530004, ChinaGuangxi Key Laboratory of Petrochemical Resource Processing & Process Intensification Technology, School of Chemistry and Chemical Engineering, Guangxi University, Nanning 530004, ChinaHebei Functional Polymer Materials R&D and Engineering Application Technology Innovation Center, College of Chemistry & Chemical Engineering, Xingtai University, Xingtai 050041, ChinaHebei Functional Polymer Materials R&D and Engineering Application Technology Innovation Center, College of Chemistry & Chemical Engineering, Xingtai University, Xingtai 050041, ChinaGuangxi Key Laboratory of Petrochemical Resource Processing & Process Intensification Technology, School of Chemistry and Chemical Engineering, Guangxi University, Nanning 530004, ChinaAmphiphilic random copolymer poly(methacrylamido-azobenzene)-<i>ran</i>-poly(2-hydroxyethylacrylate) (PMAAAB-<i>ran</i>-PHEA) was synthesized via hydrolysis of poly(methacrylamido-azobenzene)-<i>ran</i>-poly[2-((2′-tetrahydropyranyl)oxy)ethylacrylate] (PMAAAB-<i>ran</i>-P(THP-HEA)), which was prepared by conventional radical polymerization. PMAAAB-<i>ran</i>-PHEA micelles were then prepared via dialysis method against water with DMF as solvent. The structure, morphology, size, and low critical solution temperature (LCST) of PMAAAB-<i>ran</i>-PHEA and its micelles were determined by <sup>1</sup>H-NMR, GPC, TEM, and DLS. The thermo- and photo-responsive behaviors of the resulting polymer micelles were investigated with Nile red as a fluorescence probe. The results showed that PMAAAB-<i>ran</i>-PHEA micelles were porous or bowl-shaped and its size was 135–150 nm, and its LCST was 55 °C when <i>F</i><sub>MAAAB</sub> of the random copolymer was 0.5351; the hydrophobicity of the micellar core was changed reversibly under the irradiation of UV light and visible light without release of Nile red or disruption of micelles; the size and solubilization capacity of the micelles were dependent on temperature, and Nile red would migrate for many times between the water phase and the micelles, and finally increasingly accumulated during the repeated heating and cooling processes.https://www.mdpi.com/1996-1944/15/1/2methacrylamido-azobenzene2-hydroxyethylacrylateamphiphilic random copolymermicellesNile redphoto-/thermo-responsiveness |
| spellingShingle | Chuan Yan Liqin Yang Xiangquan Mo Keying Chen Weiya Niu Zhiju Zhao Guanghua Li Dual Thermo- and Photo-Responsive Micelles Based on Azobenzene-Containing Random Copolymer Materials methacrylamido-azobenzene 2-hydroxyethylacrylate amphiphilic random copolymer micelles Nile red photo-/thermo-responsiveness |
| title | Dual Thermo- and Photo-Responsive Micelles Based on Azobenzene-Containing Random Copolymer |
| title_full | Dual Thermo- and Photo-Responsive Micelles Based on Azobenzene-Containing Random Copolymer |
| title_fullStr | Dual Thermo- and Photo-Responsive Micelles Based on Azobenzene-Containing Random Copolymer |
| title_full_unstemmed | Dual Thermo- and Photo-Responsive Micelles Based on Azobenzene-Containing Random Copolymer |
| title_short | Dual Thermo- and Photo-Responsive Micelles Based on Azobenzene-Containing Random Copolymer |
| title_sort | dual thermo and photo responsive micelles based on azobenzene containing random copolymer |
| topic | methacrylamido-azobenzene 2-hydroxyethylacrylate amphiphilic random copolymer micelles Nile red photo-/thermo-responsiveness |
| url | https://www.mdpi.com/1996-1944/15/1/2 |
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