Prognostic value of inflammation-based prognostic scores on outcome in patients undergoing continuous ambulatory peritoneal dialysis
Abstract Background Inflammation-based prognostic scores have been used as outcome predictors in patients with cancer or on hemodialysis. However, their role in patients on continuous ambulatory peritoneal dialysis (CAPD) remains unclear. This study aimed to examine the prognostic value of inflammat...
| Main Authors: | , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
BMC
2018-10-01
|
| Series: | BMC Nephrology |
| Subjects: | |
| Online Access: | http://link.springer.com/article/10.1186/s12882-018-1092-1 |
| _version_ | 1818695888348905472 |
|---|---|
| author | Lu Cai Jianwen Yu Jing Yu Yuan Peng Habib Ullah Chunyan Yi Jianxiong Lin Xiao Yang Xueqing Yu |
| author_facet | Lu Cai Jianwen Yu Jing Yu Yuan Peng Habib Ullah Chunyan Yi Jianxiong Lin Xiao Yang Xueqing Yu |
| author_sort | Lu Cai |
| collection | DOAJ |
| description | Abstract Background Inflammation-based prognostic scores have been used as outcome predictors in patients with cancer or on hemodialysis. However, their role in patients on continuous ambulatory peritoneal dialysis (CAPD) remains unclear. This study aimed to examine the prognostic value of inflammation-based composite scores for mortality in CAPD patients. Methods This study was conducted in CAPD patients enrolled from January 1, 2006 to December 31, 2014 and followed until December 31, 2016. Three inflammation-based prognostic scores, including Glasgow prognostic score (GPS), prognostic nutritional index (PNI), and prognostic index (PI), were conducted in this study. The associations between these scores and all-cause or cardiovascular mortality were evaluated by Kaplan–Meier method and Cox proportional hazards models. The areas under the curve (AUC) of receiver-operating characteristic (ROC) analysis were used to determine the predictive values of mortality. Results A total of 1501 patients were included. During a median follow-up of 38.7 (range, 21.6–62.3) months, 346 (23.1%) patients died, of which 168 (48.6%) were due to cardiovascular diseases (CVD). After adjustment for confounders, the results showed that elevated GPS, PNI, and PI scores were all independently associated with all-cause [GPS: Score 1: hazard ratio(HR) 3.94, 95% confidence interval(CI) 2.90–5.35; Score 2: HR 7.56, 95% CI 5.35–10.67; PNI: HR 1.82, 95% CI 1.36–2.43; PI: Score 1: HR 2.08, 95% CI 1.63–2.65; Score 2: HR 3.03, 95% CI 2.00–4.60)] and CVD mortality(GPS: Score 1: HR 4.41, 95% CI 2.76–7.03; Score 2: HR 9.64, 95% CI 5.72–16.26; PNI: HR 1.63, 95% CI 1.06–2.51; PI: Score 1: HR 2.57, 95% CI 1.81–3.66, Score 2: HR 3.85, 95% CI 1.99–7.46).The AUC values of GPS score were 0.798 (95% CI0.770–0.826) for all-cause mortality and 0.781 (95% CI 0.744–0.817) for CVD mortality, both of which significantly higher than those of PNI and PI scores (P < 0.001, respectively). Conclusions All elevated GPS, PNI, and PI scores were independently associated with all-cause and CVD mortality. The GPS score showed better predictive value than PNI and PI scores in CAPD patients. |
| first_indexed | 2024-12-17T13:52:38Z |
| format | Article |
| id | doaj.art-01cdfbdac38545f6ac82cb63bec1d999 |
| institution | Directory Open Access Journal |
| issn | 1471-2369 |
| language | English |
| last_indexed | 2024-12-17T13:52:38Z |
| publishDate | 2018-10-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Nephrology |
| spelling | doaj.art-01cdfbdac38545f6ac82cb63bec1d9992022-12-21T21:46:00ZengBMCBMC Nephrology1471-23692018-10-0119111010.1186/s12882-018-1092-1Prognostic value of inflammation-based prognostic scores on outcome in patients undergoing continuous ambulatory peritoneal dialysisLu Cai0Jianwen Yu1Jing Yu2Yuan Peng3Habib Ullah4Chunyan Yi5Jianxiong Lin6Xiao Yang7Xueqing Yu8Department of Nephrology, The First Affiliated Hospital of Sun Yat-sen UniversityDepartment of Nephrology, The First Affiliated Hospital of Sun Yat-sen UniversityDepartment of Nephrology, The First Affiliated Hospital of Sun Yat-sen UniversityDepartment of Nephrology, The First Affiliated Hospital of Sun Yat-sen UniversityDepartment of Nephrology, The First Affiliated Hospital of Sun Yat-sen UniversityDepartment of Nephrology, The First Affiliated Hospital of Sun Yat-sen UniversityDepartment of Nephrology, The First Affiliated Hospital of Sun Yat-sen UniversityDepartment of Nephrology, The First Affiliated Hospital of Sun Yat-sen UniversityDepartment of Nephrology, The First Affiliated Hospital of Sun Yat-sen UniversityAbstract Background Inflammation-based prognostic scores have been used as outcome predictors in patients with cancer or on hemodialysis. However, their role in patients on continuous ambulatory peritoneal dialysis (CAPD) remains unclear. This study aimed to examine the prognostic value of inflammation-based composite scores for mortality in CAPD patients. Methods This study was conducted in CAPD patients enrolled from January 1, 2006 to December 31, 2014 and followed until December 31, 2016. Three inflammation-based prognostic scores, including Glasgow prognostic score (GPS), prognostic nutritional index (PNI), and prognostic index (PI), were conducted in this study. The associations between these scores and all-cause or cardiovascular mortality were evaluated by Kaplan–Meier method and Cox proportional hazards models. The areas under the curve (AUC) of receiver-operating characteristic (ROC) analysis were used to determine the predictive values of mortality. Results A total of 1501 patients were included. During a median follow-up of 38.7 (range, 21.6–62.3) months, 346 (23.1%) patients died, of which 168 (48.6%) were due to cardiovascular diseases (CVD). After adjustment for confounders, the results showed that elevated GPS, PNI, and PI scores were all independently associated with all-cause [GPS: Score 1: hazard ratio(HR) 3.94, 95% confidence interval(CI) 2.90–5.35; Score 2: HR 7.56, 95% CI 5.35–10.67; PNI: HR 1.82, 95% CI 1.36–2.43; PI: Score 1: HR 2.08, 95% CI 1.63–2.65; Score 2: HR 3.03, 95% CI 2.00–4.60)] and CVD mortality(GPS: Score 1: HR 4.41, 95% CI 2.76–7.03; Score 2: HR 9.64, 95% CI 5.72–16.26; PNI: HR 1.63, 95% CI 1.06–2.51; PI: Score 1: HR 2.57, 95% CI 1.81–3.66, Score 2: HR 3.85, 95% CI 1.99–7.46).The AUC values of GPS score were 0.798 (95% CI0.770–0.826) for all-cause mortality and 0.781 (95% CI 0.744–0.817) for CVD mortality, both of which significantly higher than those of PNI and PI scores (P < 0.001, respectively). Conclusions All elevated GPS, PNI, and PI scores were independently associated with all-cause and CVD mortality. The GPS score showed better predictive value than PNI and PI scores in CAPD patients.http://link.springer.com/article/10.1186/s12882-018-1092-1Inflammation-based prognostic scoresContinuous ambulatory peritoneal dialysisAll-cause mortalityCardiovascular mortality |
| spellingShingle | Lu Cai Jianwen Yu Jing Yu Yuan Peng Habib Ullah Chunyan Yi Jianxiong Lin Xiao Yang Xueqing Yu Prognostic value of inflammation-based prognostic scores on outcome in patients undergoing continuous ambulatory peritoneal dialysis BMC Nephrology Inflammation-based prognostic scores Continuous ambulatory peritoneal dialysis All-cause mortality Cardiovascular mortality |
| title | Prognostic value of inflammation-based prognostic scores on outcome in patients undergoing continuous ambulatory peritoneal dialysis |
| title_full | Prognostic value of inflammation-based prognostic scores on outcome in patients undergoing continuous ambulatory peritoneal dialysis |
| title_fullStr | Prognostic value of inflammation-based prognostic scores on outcome in patients undergoing continuous ambulatory peritoneal dialysis |
| title_full_unstemmed | Prognostic value of inflammation-based prognostic scores on outcome in patients undergoing continuous ambulatory peritoneal dialysis |
| title_short | Prognostic value of inflammation-based prognostic scores on outcome in patients undergoing continuous ambulatory peritoneal dialysis |
| title_sort | prognostic value of inflammation based prognostic scores on outcome in patients undergoing continuous ambulatory peritoneal dialysis |
| topic | Inflammation-based prognostic scores Continuous ambulatory peritoneal dialysis All-cause mortality Cardiovascular mortality |
| url | http://link.springer.com/article/10.1186/s12882-018-1092-1 |
| work_keys_str_mv | AT lucai prognosticvalueofinflammationbasedprognosticscoresonoutcomeinpatientsundergoingcontinuousambulatoryperitonealdialysis AT jianwenyu prognosticvalueofinflammationbasedprognosticscoresonoutcomeinpatientsundergoingcontinuousambulatoryperitonealdialysis AT jingyu prognosticvalueofinflammationbasedprognosticscoresonoutcomeinpatientsundergoingcontinuousambulatoryperitonealdialysis AT yuanpeng prognosticvalueofinflammationbasedprognosticscoresonoutcomeinpatientsundergoingcontinuousambulatoryperitonealdialysis AT habibullah prognosticvalueofinflammationbasedprognosticscoresonoutcomeinpatientsundergoingcontinuousambulatoryperitonealdialysis AT chunyanyi prognosticvalueofinflammationbasedprognosticscoresonoutcomeinpatientsundergoingcontinuousambulatoryperitonealdialysis AT jianxionglin prognosticvalueofinflammationbasedprognosticscoresonoutcomeinpatientsundergoingcontinuousambulatoryperitonealdialysis AT xiaoyang prognosticvalueofinflammationbasedprognosticscoresonoutcomeinpatientsundergoingcontinuousambulatoryperitonealdialysis AT xueqingyu prognosticvalueofinflammationbasedprognosticscoresonoutcomeinpatientsundergoingcontinuousambulatoryperitonealdialysis |