Recent progress of hydrogel-based local drug delivery systems for postoperative radiotherapy
Surgical resection and postoperative radiotherapy remained the most common therapeutic modalities for malignant tumors. However, tumor recurrence after receiving such combination is difficult to be avoided because of high invasiveness and radiation resistance of cancer cells during long-term therapy...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2023-02-01
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| Series: | Frontiers in Oncology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fonc.2023.1027254/full |
| _version_ | 1811165238343499776 |
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| author | Yandong Xie Yandong Xie Mingxi Liu Chang Cai Chengkun Ye Tangjun Guo Kun Yang Hong Xiao Xianglong Tang Xianglong Tang Hongyi Liu |
| author_facet | Yandong Xie Yandong Xie Mingxi Liu Chang Cai Chengkun Ye Tangjun Guo Kun Yang Hong Xiao Xianglong Tang Xianglong Tang Hongyi Liu |
| author_sort | Yandong Xie |
| collection | DOAJ |
| description | Surgical resection and postoperative radiotherapy remained the most common therapeutic modalities for malignant tumors. However, tumor recurrence after receiving such combination is difficult to be avoided because of high invasiveness and radiation resistance of cancer cells during long-term therapy. Hydrogels, as novel local drug delivery systems, presented excellent biocompatibility, high drug loading capacity and sustained drug release property. Compared with conventional drug formulations, hydrogels are able to be administered intraoperatively and directly release the entrapped therapeutic agents to the unresectable tumor sites. Therefore, hydrogel-based local drug delivery systems have their unique advantages especially in sensitizing postoperative radiotherapy. In this context, classification and biological properties of hydrogels were firstly introduced. Then, recent progress and application of hydrogels for postoperative radiotherapy were summarized. Finally, the prospects and challenges of hydrogels in postoperative radiotherapy were discussed. |
| first_indexed | 2024-04-10T15:34:04Z |
| format | Article |
| id | doaj.art-01ce76ca950b415c898ed7fa935170ca |
| institution | Directory Open Access Journal |
| issn | 2234-943X |
| language | English |
| last_indexed | 2024-04-10T15:34:04Z |
| publishDate | 2023-02-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Oncology |
| spelling | doaj.art-01ce76ca950b415c898ed7fa935170ca2023-02-13T08:01:25ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2023-02-011310.3389/fonc.2023.10272541027254Recent progress of hydrogel-based local drug delivery systems for postoperative radiotherapyYandong Xie0Yandong Xie1Mingxi Liu2Chang Cai3Chengkun Ye4Tangjun Guo5Kun Yang6Hong Xiao7Xianglong Tang8Xianglong Tang9Hongyi Liu10Department of Neurosurgery, Affiliated Nanjing Brain Hospital, Nanjing Medical University, Nanjing, ChinaDepartment of Neurosurgery, The Suqian Clinical College of Xuzhou Medical University, Suqian, ChinaDepartment of Neurosurgery, Affiliated Nanjing Brain Hospital, Nanjing Medical University, Nanjing, ChinaDepartment of Neurosurgery, The Suqian Clinical College of Xuzhou Medical University, Suqian, ChinaDivision of Life Sciences and Medicine, University of Science and Technology of China, Hefei, ChinaDepartment of Neurosurgery, Affiliated Hospital of Xuzhou Medical University, Xuzhou, ChinaDepartment of Neurosurgery, Affiliated Nanjing Brain Hospital, Nanjing Medical University, Nanjing, ChinaDepartment of Neuro-Psychiatric Institute, Affiliated Nanjing Brain Hospital, Nanjing Medical University, Nanjing, ChinaDepartment of Neurosurgery, Affiliated Nanjing Brain Hospital, Nanjing Medical University, Nanjing, ChinaDepartment of Neuro-Psychiatric Institute, Affiliated Nanjing Brain Hospital, Nanjing Medical University, Nanjing, ChinaDepartment of Neurosurgery, Affiliated Nanjing Brain Hospital, Nanjing Medical University, Nanjing, ChinaSurgical resection and postoperative radiotherapy remained the most common therapeutic modalities for malignant tumors. However, tumor recurrence after receiving such combination is difficult to be avoided because of high invasiveness and radiation resistance of cancer cells during long-term therapy. Hydrogels, as novel local drug delivery systems, presented excellent biocompatibility, high drug loading capacity and sustained drug release property. Compared with conventional drug formulations, hydrogels are able to be administered intraoperatively and directly release the entrapped therapeutic agents to the unresectable tumor sites. Therefore, hydrogel-based local drug delivery systems have their unique advantages especially in sensitizing postoperative radiotherapy. In this context, classification and biological properties of hydrogels were firstly introduced. Then, recent progress and application of hydrogels for postoperative radiotherapy were summarized. Finally, the prospects and challenges of hydrogels in postoperative radiotherapy were discussed.https://www.frontiersin.org/articles/10.3389/fonc.2023.1027254/fullhydrogelpostoperative radiotherapyradiation sensitizationlocal drug deliverytumor recurrence |
| spellingShingle | Yandong Xie Yandong Xie Mingxi Liu Chang Cai Chengkun Ye Tangjun Guo Kun Yang Hong Xiao Xianglong Tang Xianglong Tang Hongyi Liu Recent progress of hydrogel-based local drug delivery systems for postoperative radiotherapy Frontiers in Oncology hydrogel postoperative radiotherapy radiation sensitization local drug delivery tumor recurrence |
| title | Recent progress of hydrogel-based local drug delivery systems for postoperative radiotherapy |
| title_full | Recent progress of hydrogel-based local drug delivery systems for postoperative radiotherapy |
| title_fullStr | Recent progress of hydrogel-based local drug delivery systems for postoperative radiotherapy |
| title_full_unstemmed | Recent progress of hydrogel-based local drug delivery systems for postoperative radiotherapy |
| title_short | Recent progress of hydrogel-based local drug delivery systems for postoperative radiotherapy |
| title_sort | recent progress of hydrogel based local drug delivery systems for postoperative radiotherapy |
| topic | hydrogel postoperative radiotherapy radiation sensitization local drug delivery tumor recurrence |
| url | https://www.frontiersin.org/articles/10.3389/fonc.2023.1027254/full |
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