Perioperative effects of various anesthetic adjuvants with TIVA guided by bispectral index
BackgroundThis prospective, randomized, double blinded, controlled study was designed to compare effects of intravenous co-administration of clonidine, magnesium, or ketamine on anesthetic consumption, intraoperative hemodynamics, postoperative analgesia and recovery indices during Bispectral Index...
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| Format: | Article |
| Language: | English |
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Korean Society of Anesthesiologists
2012-08-01
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| Series: | Korean Journal of Anesthesiology |
| Subjects: | |
| Online Access: | http://ekja.org/upload/pdf/kjae-63-113.pdf |
| _version_ | 1819229871427026944 |
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| author | Hanan F. Khafagy Reeham S. Ebied Emad S. Osman Mohamed Z. Ali Yasser M. Samhan |
| author_facet | Hanan F. Khafagy Reeham S. Ebied Emad S. Osman Mohamed Z. Ali Yasser M. Samhan |
| author_sort | Hanan F. Khafagy |
| collection | DOAJ |
| description | BackgroundThis prospective, randomized, double blinded, controlled study was designed to compare effects of intravenous co-administration of clonidine, magnesium, or ketamine on anesthetic consumption, intraoperative hemodynamics, postoperative analgesia and recovery indices during Bispectral Index (BIS) guided total intravenous anesthesia (TIVA).MethodsAfter ethical committee approval and written informed consent, 120 adult patients ASA I and II scheduled for open cholecystectomy were randomly assigned to one of 4 equal groups. Group CL received clonidine 3 µg/kg and maintained by 2 µg/kg/h. Group MG received magnesium sulphate 50 mg/kg and maintained by 8 mg/kg/h. Group KET received racemic ketamine 0.4 mg/kg and maintained by 0.2 mg/kg/h. Control group (CT) received the same volume of isotonic saline. Anesthesia was induced and maintained by fentanyl, propofol and rocuronium. Propofol infusion was adjusted to keep the BIS value between 45-55. Intraoperative hemodynamics, induction time, anesthetic consumption, recovery indices, and PACU discharge were recorded.ResultsInduction time, propofol requirements for induction and maintenance of anesthesia, intraoperative fentanyl and hemodynamic values were significantly lower with Groups CL and MG compared to Groups KET and CT (P < 0.05). Patients in Group MG showed significantly lower muscle relaxant consumption, delayed recovery and PACU discharge than other groups (P < 0.05). First, analgesic requirement was significantly longer and total postoperative analgesic consumption was significantly lower in the adjuvant groups versus Group CT (P < 0.05).ConclusionsClonidine, magnesium, and ketamine can be useful adjuvant agents to BIS-guided TIVA. Pharmacokinetic studies of such drug combinations were recommended to investigate their interaction. |
| first_indexed | 2024-12-23T11:20:04Z |
| format | Article |
| id | doaj.art-01d340a64c2746c3a3e9fdac94f7a4c4 |
| institution | Directory Open Access Journal |
| issn | 2005-6419 2005-7563 |
| language | English |
| last_indexed | 2024-12-23T11:20:04Z |
| publishDate | 2012-08-01 |
| publisher | Korean Society of Anesthesiologists |
| record_format | Article |
| series | Korean Journal of Anesthesiology |
| spelling | doaj.art-01d340a64c2746c3a3e9fdac94f7a4c42022-12-21T17:49:06ZengKorean Society of AnesthesiologistsKorean Journal of Anesthesiology2005-64192005-75632012-08-0163211311910.4097/kjae.2012.63.2.1137387Perioperative effects of various anesthetic adjuvants with TIVA guided by bispectral indexHanan F. Khafagy0Reeham S. Ebied1Emad S. Osman2Mohamed Z. Ali3Yasser M. Samhan4Department of Anesthesiology, Theodor Bilharz Research Institute, Ministry of High Education and Scientific Research, Giza, Egypt.Department of Anesthesiology, Theodor Bilharz Research Institute, Ministry of High Education and Scientific Research, Giza, Egypt.Department of Anesthesiology, Theodor Bilharz Research Institute, Ministry of High Education and Scientific Research, Giza, Egypt.Department of Anesthesiology, Theodor Bilharz Research Institute, Ministry of High Education and Scientific Research, Giza, Egypt.Department of Anesthesiology, Theodor Bilharz Research Institute, Ministry of High Education and Scientific Research, Giza, Egypt.BackgroundThis prospective, randomized, double blinded, controlled study was designed to compare effects of intravenous co-administration of clonidine, magnesium, or ketamine on anesthetic consumption, intraoperative hemodynamics, postoperative analgesia and recovery indices during Bispectral Index (BIS) guided total intravenous anesthesia (TIVA).MethodsAfter ethical committee approval and written informed consent, 120 adult patients ASA I and II scheduled for open cholecystectomy were randomly assigned to one of 4 equal groups. Group CL received clonidine 3 µg/kg and maintained by 2 µg/kg/h. Group MG received magnesium sulphate 50 mg/kg and maintained by 8 mg/kg/h. Group KET received racemic ketamine 0.4 mg/kg and maintained by 0.2 mg/kg/h. Control group (CT) received the same volume of isotonic saline. Anesthesia was induced and maintained by fentanyl, propofol and rocuronium. Propofol infusion was adjusted to keep the BIS value between 45-55. Intraoperative hemodynamics, induction time, anesthetic consumption, recovery indices, and PACU discharge were recorded.ResultsInduction time, propofol requirements for induction and maintenance of anesthesia, intraoperative fentanyl and hemodynamic values were significantly lower with Groups CL and MG compared to Groups KET and CT (P < 0.05). Patients in Group MG showed significantly lower muscle relaxant consumption, delayed recovery and PACU discharge than other groups (P < 0.05). First, analgesic requirement was significantly longer and total postoperative analgesic consumption was significantly lower in the adjuvant groups versus Group CT (P < 0.05).ConclusionsClonidine, magnesium, and ketamine can be useful adjuvant agents to BIS-guided TIVA. Pharmacokinetic studies of such drug combinations were recommended to investigate their interaction.http://ekja.org/upload/pdf/kjae-63-113.pdfbisclonidineketaminemagnesiumtiva |
| spellingShingle | Hanan F. Khafagy Reeham S. Ebied Emad S. Osman Mohamed Z. Ali Yasser M. Samhan Perioperative effects of various anesthetic adjuvants with TIVA guided by bispectral index Korean Journal of Anesthesiology bis clonidine ketamine magnesium tiva |
| title | Perioperative effects of various anesthetic adjuvants with TIVA guided by bispectral index |
| title_full | Perioperative effects of various anesthetic adjuvants with TIVA guided by bispectral index |
| title_fullStr | Perioperative effects of various anesthetic adjuvants with TIVA guided by bispectral index |
| title_full_unstemmed | Perioperative effects of various anesthetic adjuvants with TIVA guided by bispectral index |
| title_short | Perioperative effects of various anesthetic adjuvants with TIVA guided by bispectral index |
| title_sort | perioperative effects of various anesthetic adjuvants with tiva guided by bispectral index |
| topic | bis clonidine ketamine magnesium tiva |
| url | http://ekja.org/upload/pdf/kjae-63-113.pdf |
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