Distribution Occurrence of Phenylketonuria in the World: A Systematic Review and Meta-Analysis
Background and objectives : Phenylketonuria (PKU) is a metabolic error which is caused by the deficiency of phenylalanine hydroxylase (PAH) inverting phenylalanine to tyrosine. This disease is the most common form of hyperphenyalaninaemia stow which is inherited in a form of a predominant autosoma...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | fas |
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Tabriz University of Medical Sciences
2016-03-01
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| Series: | Taṣvīr-i salāmat |
| Subjects: | |
| Online Access: | https://doh.tbzmed.ac.ir/PDF/doh-134.pdf |
| _version_ | 1818281171271811072 |
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| author | Parastoo Moradi Behrooz Sari Sarraf Zhila Khamnian Roya Dolatkhah Soraya Hadi Dorna Ghafari Saeid Dastgiri |
| author_facet | Parastoo Moradi Behrooz Sari Sarraf Zhila Khamnian Roya Dolatkhah Soraya Hadi Dorna Ghafari Saeid Dastgiri |
| author_sort | Parastoo Moradi |
| collection | DOAJ |
| description | Background and objectives : Phenylketonuria (PKU) is a metabolic error which is caused by the deficiency of phenylalanine hydroxylase (PAH) inverting phenylalanine to tyrosine. This disease is the most common form of hyperphenyalaninaemia stow which is inherited in a form of a predominant autosomal. Therefore, the aim of this study was to investigate the distribution of occurrence of phenylketonuria disease in the world by using the systematic review and meta-analysis. Material and Methods : The national and international databases such as Medline, CINAHL, Embase, PubMed and OVID, Google scholar, IranDOC, IranMedex, SID, Magiran, have been searched from 1990 onwards, without language restrictions and by using the key words: phenylketonuria, prevalence, incidence, congenital diseases. A total of 304 articles related with this topic were found. Finally, 62 studies were accepted. Data were analyzed by using Comprehensive Meta-Analysis software at 95% confidence level. The distribution of diseases was shown by using Geographic Information System software on the world map. Results : The findings showed that in 100000 people, the best estimate of the disease prevalence of phenylketonuria is 11.83 (95% CI: 10.22- 13.44) and the best estimate of the incidence of this disease is 8.2 (95% CI: 6.37- 10.03) in the world. The distribution of phenylketonuria disease has the highest rate in Europe and Asia and lowest rate in Africa and America, respectively. Conclusion : According to the findings of the present study, it can be said that there is a wide variety in the occurrence of phenylketonuria in the world and recent studies have confirmed his. Therefore, because of the irreversible consequences of the disease, the development of the appropriate training and control programs is recommended to reduce the occurrence of the disease. |
| first_indexed | 2024-12-13T00:00:53Z |
| format | Article |
| id | doaj.art-01d54e08d28441029f275c984ad2a09c |
| institution | Directory Open Access Journal |
| issn | 2008-9058 2423-6640 |
| language | fas |
| last_indexed | 2024-12-13T00:00:53Z |
| publishDate | 2016-03-01 |
| publisher | Tabriz University of Medical Sciences |
| record_format | Article |
| series | Taṣvīr-i salāmat |
| spelling | doaj.art-01d54e08d28441029f275c984ad2a09c2022-12-22T00:06:25ZfasTabriz University of Medical SciencesTaṣvīr-i salāmat2008-90582423-66402016-03-0164112DOH_141_20170209100151Distribution Occurrence of Phenylketonuria in the World: A Systematic Review and Meta-AnalysisParastoo Moradi0Behrooz Sari Sarraf1Zhila Khamnian2Roya Dolatkhah3Soraya Hadi4Dorna Ghafari5Saeid Dastgiri6Medical Geography M.A. student, Faculty of Geography and Planning, Tabriz University, IranProfessor, Faculty of Geography and Planning, Tabriz University, Tabriz, IranAssistant Professor, Social Determinants of Health Research Center, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, IranMolecular Epidemiology of Cancer, Hematology and Oncology Research Center, Tabriz University of Medical Sciences, Tabriz, IranMedical Geography M.A. student, Faculty of Geography and Planning, Tabriz University, Iran Medical Geography M.A. student, Faculty of Geography and Planning, Tabriz University, IranProfessor, Tabriz Health Management Research Center, Tabriz University of Medical Sciences, Tabriz, Iran Background and objectives : Phenylketonuria (PKU) is a metabolic error which is caused by the deficiency of phenylalanine hydroxylase (PAH) inverting phenylalanine to tyrosine. This disease is the most common form of hyperphenyalaninaemia stow which is inherited in a form of a predominant autosomal. Therefore, the aim of this study was to investigate the distribution of occurrence of phenylketonuria disease in the world by using the systematic review and meta-analysis. Material and Methods : The national and international databases such as Medline, CINAHL, Embase, PubMed and OVID, Google scholar, IranDOC, IranMedex, SID, Magiran, have been searched from 1990 onwards, without language restrictions and by using the key words: phenylketonuria, prevalence, incidence, congenital diseases. A total of 304 articles related with this topic were found. Finally, 62 studies were accepted. Data were analyzed by using Comprehensive Meta-Analysis software at 95% confidence level. The distribution of diseases was shown by using Geographic Information System software on the world map. Results : The findings showed that in 100000 people, the best estimate of the disease prevalence of phenylketonuria is 11.83 (95% CI: 10.22- 13.44) and the best estimate of the incidence of this disease is 8.2 (95% CI: 6.37- 10.03) in the world. The distribution of phenylketonuria disease has the highest rate in Europe and Asia and lowest rate in Africa and America, respectively. Conclusion : According to the findings of the present study, it can be said that there is a wide variety in the occurrence of phenylketonuria in the world and recent studies have confirmed his. Therefore, because of the irreversible consequences of the disease, the development of the appropriate training and control programs is recommended to reduce the occurrence of the disease.https://doh.tbzmed.ac.ir/PDF/doh-134.pdfprevalence,phenylketonuriacongenital diseaseincidencemeta-analysis |
| spellingShingle | Parastoo Moradi Behrooz Sari Sarraf Zhila Khamnian Roya Dolatkhah Soraya Hadi Dorna Ghafari Saeid Dastgiri Distribution Occurrence of Phenylketonuria in the World: A Systematic Review and Meta-Analysis Taṣvīr-i salāmat prevalence, phenylketonuria congenital disease incidence meta-analysis |
| title | Distribution Occurrence of Phenylketonuria in the World: A Systematic Review and Meta-Analysis |
| title_full | Distribution Occurrence of Phenylketonuria in the World: A Systematic Review and Meta-Analysis |
| title_fullStr | Distribution Occurrence of Phenylketonuria in the World: A Systematic Review and Meta-Analysis |
| title_full_unstemmed | Distribution Occurrence of Phenylketonuria in the World: A Systematic Review and Meta-Analysis |
| title_short | Distribution Occurrence of Phenylketonuria in the World: A Systematic Review and Meta-Analysis |
| title_sort | distribution occurrence of phenylketonuria in the world a systematic review and meta analysis |
| topic | prevalence, phenylketonuria congenital disease incidence meta-analysis |
| url | https://doh.tbzmed.ac.ir/PDF/doh-134.pdf |
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