A Central Small Amino Acid in the VAMP2 Transmembrane Domain Regulates the Fusion Pore in Exocytosis

A Central Small Amino Acid in the VAMP2 Transmembrane Domain Regulates the Fusion Pore in Exocytosis

Abstract Exocytosis depends on cytosolic domains of SNARE proteins but the function of the transmembrane domains (TMDs) in membrane fusion remains controversial. The TMD of the SNARE protein synaptobrevin2/VAMP2 contains two highly conserved small amino acids, G100 and C103, in its central portion....

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Bibliographic Details
Main Authors: Benoît Hastoy, Pier A. Scotti, Alexandra Milochau, Zahia Fezoua-Boubegtiten, Jorge Rodas, Rémi Megret, Bernard Desbat, Michel Laguerre, Sabine Castano, David Perrais, Patrik Rorsman, Reiko Oda, Jochen Lang
Format: Article
Language:English
Published: Nature Portfolio 2017-06-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-017-03013-3

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