Qualitative Heterogeneous Signal Drop on Chemical Shift (CS) MR Imaging: Correlative Quantitative Analysis between CS Signal Intensity Index and Contrast Washout Parameters Using T1-Weighted Sequences
The aim of this study was to calculate MRI quantitative parameters extracted from chemical-shift (CS) and dynamic contrast-enhanced (DCE) T1-weighted (T1-WS) images of adrenal lesions (AL) with qualitative heterogeneous signal drop on CS T1-WS and compare them to those of AL with homogeneous or no s...
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MDPI AG
2021-12-01
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| Series: | Tomography |
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| Online Access: | https://www.mdpi.com/2379-139X/7/4/79 |
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| author | Arnaldo Stanzione Francesco Verde Roberta Galatola Valeria Romeo Raffaele Liuzzi Pier Paolo Mainenti Giovanni Aprea Michele Klain Elia Guadagno Marialaura Del Basso De Caro Simone Maurea |
| author_facet | Arnaldo Stanzione Francesco Verde Roberta Galatola Valeria Romeo Raffaele Liuzzi Pier Paolo Mainenti Giovanni Aprea Michele Klain Elia Guadagno Marialaura Del Basso De Caro Simone Maurea |
| author_sort | Arnaldo Stanzione |
| collection | DOAJ |
| description | The aim of this study was to calculate MRI quantitative parameters extracted from chemical-shift (CS) and dynamic contrast-enhanced (DCE) T1-weighted (T1-WS) images of adrenal lesions (AL) with qualitative heterogeneous signal drop on CS T1-WS and compare them to those of AL with homogeneous or no signal drop on CS T1-WS. On 3 T MRI, 65 patients with a total of 72 AL were studied. CS images were qualitatively assessed for grouping AL as showing homogeneous (Group 1, <i>n</i> = 19), heterogeneous (Group 2, <i>n</i> = 23), and no (Group 3, <i>n</i> = 30) signal drop. Histopathology or follow-up data served as reference standard to classify AL. ROIs were drawn both on CS and DCE images to obtain adrenal CS signal intensity index (ASII), absolute (AWO), and relative washout (RWO) values. Quantitative parameters (QP) were compared with ANOVA analysis and post hoc Dunn’s test. The performance of QP to classify AL was assessed with receiver operating characteristic analysis. CS ASII values were significantly different among the three groups (<i>p</i> < 0.001) with median values of 71%, 53%, and 3%, respectively. AWO/RWO values were similar in Groups 1 (adenomas) and 2 (benign AL) but significantly (<i>p</i> < 0.001) lower in Group 3 (20 benign AL and 10 malignant AL). With cut-offs, respectively, of 60% (Group 1 vs. 2), 20% (Group 2 vs. 3), and 37% (Group 1 vs. 3), CS ASII showed areas under the curve of 0.85, 0.96, and 0.93 for the classification of AL, overall higher than AWO/RWO. In conclusion, AL with qualitative heterogeneous signal drop at CS represent benign AL with QP by DCE sequence similar to those of AL with homogeneous signal drop at CS, but different to those of AL with no signal drop at CS; ASII seems to be the only quantitative parameter able to differentiate AL among the three different groups. |
| first_indexed | 2024-03-10T03:58:36Z |
| format | Article |
| id | doaj.art-01d6b366c2a74f67a342ac6fdc92bf97 |
| institution | Directory Open Access Journal |
| issn | 2379-1381 2379-139X |
| language | English |
| last_indexed | 2024-03-10T03:58:36Z |
| publishDate | 2021-12-01 |
| publisher | MDPI AG |
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| series | Tomography |
| spelling | doaj.art-01d6b366c2a74f67a342ac6fdc92bf972023-11-23T10:49:25ZengMDPI AGTomography2379-13812379-139X2021-12-017496197110.3390/tomography7040079Qualitative Heterogeneous Signal Drop on Chemical Shift (CS) MR Imaging: Correlative Quantitative Analysis between CS Signal Intensity Index and Contrast Washout Parameters Using T1-Weighted SequencesArnaldo Stanzione0Francesco Verde1Roberta Galatola2Valeria Romeo3Raffaele Liuzzi4Pier Paolo Mainenti5Giovanni Aprea6Michele Klain7Elia Guadagno8Marialaura Del Basso De Caro9Simone Maurea10Department of Advanced Biomedical Sciences, University of Naples “Federico II”, 80131 Naples, ItalyDepartment of Advanced Biomedical Sciences, University of Naples “Federico II”, 80131 Naples, ItalyDepartment of Advanced Biomedical Sciences, University of Naples “Federico II”, 80131 Naples, ItalyDepartment of Advanced Biomedical Sciences, University of Naples “Federico II”, 80131 Naples, ItalyInstitute of Biostructures and Bioimaging, The National Research Council (CNR), 80131 Naples, ItalyInstitute of Biostructures and Bioimaging, The National Research Council (CNR), 80131 Naples, ItalyDepartment of Clinical Medicine and Surgery, University of Naples “Federico II”, 80131 Naples, ItalyDepartment of Advanced Biomedical Sciences, University of Naples “Federico II”, 80131 Naples, ItalyDepartment of Advanced Biomedical Sciences, University of Naples “Federico II”, 80131 Naples, ItalyDepartment of Advanced Biomedical Sciences, University of Naples “Federico II”, 80131 Naples, ItalyDepartment of Advanced Biomedical Sciences, University of Naples “Federico II”, 80131 Naples, ItalyThe aim of this study was to calculate MRI quantitative parameters extracted from chemical-shift (CS) and dynamic contrast-enhanced (DCE) T1-weighted (T1-WS) images of adrenal lesions (AL) with qualitative heterogeneous signal drop on CS T1-WS and compare them to those of AL with homogeneous or no signal drop on CS T1-WS. On 3 T MRI, 65 patients with a total of 72 AL were studied. CS images were qualitatively assessed for grouping AL as showing homogeneous (Group 1, <i>n</i> = 19), heterogeneous (Group 2, <i>n</i> = 23), and no (Group 3, <i>n</i> = 30) signal drop. Histopathology or follow-up data served as reference standard to classify AL. ROIs were drawn both on CS and DCE images to obtain adrenal CS signal intensity index (ASII), absolute (AWO), and relative washout (RWO) values. Quantitative parameters (QP) were compared with ANOVA analysis and post hoc Dunn’s test. The performance of QP to classify AL was assessed with receiver operating characteristic analysis. CS ASII values were significantly different among the three groups (<i>p</i> < 0.001) with median values of 71%, 53%, and 3%, respectively. AWO/RWO values were similar in Groups 1 (adenomas) and 2 (benign AL) but significantly (<i>p</i> < 0.001) lower in Group 3 (20 benign AL and 10 malignant AL). With cut-offs, respectively, of 60% (Group 1 vs. 2), 20% (Group 2 vs. 3), and 37% (Group 1 vs. 3), CS ASII showed areas under the curve of 0.85, 0.96, and 0.93 for the classification of AL, overall higher than AWO/RWO. In conclusion, AL with qualitative heterogeneous signal drop at CS represent benign AL with QP by DCE sequence similar to those of AL with homogeneous signal drop at CS, but different to those of AL with no signal drop at CS; ASII seems to be the only quantitative parameter able to differentiate AL among the three different groups.https://www.mdpi.com/2379-139X/7/4/79adrenal tumorsMRIquantitative imagingchemical shiftdynamic post-contrast sequence |
| spellingShingle | Arnaldo Stanzione Francesco Verde Roberta Galatola Valeria Romeo Raffaele Liuzzi Pier Paolo Mainenti Giovanni Aprea Michele Klain Elia Guadagno Marialaura Del Basso De Caro Simone Maurea Qualitative Heterogeneous Signal Drop on Chemical Shift (CS) MR Imaging: Correlative Quantitative Analysis between CS Signal Intensity Index and Contrast Washout Parameters Using T1-Weighted Sequences Tomography adrenal tumors MRI quantitative imaging chemical shift dynamic post-contrast sequence |
| title | Qualitative Heterogeneous Signal Drop on Chemical Shift (CS) MR Imaging: Correlative Quantitative Analysis between CS Signal Intensity Index and Contrast Washout Parameters Using T1-Weighted Sequences |
| title_full | Qualitative Heterogeneous Signal Drop on Chemical Shift (CS) MR Imaging: Correlative Quantitative Analysis between CS Signal Intensity Index and Contrast Washout Parameters Using T1-Weighted Sequences |
| title_fullStr | Qualitative Heterogeneous Signal Drop on Chemical Shift (CS) MR Imaging: Correlative Quantitative Analysis between CS Signal Intensity Index and Contrast Washout Parameters Using T1-Weighted Sequences |
| title_full_unstemmed | Qualitative Heterogeneous Signal Drop on Chemical Shift (CS) MR Imaging: Correlative Quantitative Analysis between CS Signal Intensity Index and Contrast Washout Parameters Using T1-Weighted Sequences |
| title_short | Qualitative Heterogeneous Signal Drop on Chemical Shift (CS) MR Imaging: Correlative Quantitative Analysis between CS Signal Intensity Index and Contrast Washout Parameters Using T1-Weighted Sequences |
| title_sort | qualitative heterogeneous signal drop on chemical shift cs mr imaging correlative quantitative analysis between cs signal intensity index and contrast washout parameters using t1 weighted sequences |
| topic | adrenal tumors MRI quantitative imaging chemical shift dynamic post-contrast sequence |
| url | https://www.mdpi.com/2379-139X/7/4/79 |
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