Recent Progress and Advances of Multi-Stimuli-Responsive Dendrimers in Drug Delivery for Cancer Treatment
Despite the fact that nanocarriers as drug delivery systems overcome the limitation of chemotherapy, the leakage of encapsulated drugs during the delivery process to the target site can still cause toxic effects to healthy cells in other tissues and organs in the body. Controlling drug release at th...
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| Format: | Article |
| Language: | English |
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MDPI AG
2019-11-01
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| Series: | Pharmaceutics |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1999-4923/11/11/591 |
| _version_ | 1818035797420408832 |
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| author | Ngoc Thuy Trang Le Thi Nhu Quynh Nguyen Van Du Cao Duc Thuan Hoang Van Cuong Ngo Thai Thanh Hoang Thi |
| author_facet | Ngoc Thuy Trang Le Thi Nhu Quynh Nguyen Van Du Cao Duc Thuan Hoang Van Cuong Ngo Thai Thanh Hoang Thi |
| author_sort | Ngoc Thuy Trang Le |
| collection | DOAJ |
| description | Despite the fact that nanocarriers as drug delivery systems overcome the limitation of chemotherapy, the leakage of encapsulated drugs during the delivery process to the target site can still cause toxic effects to healthy cells in other tissues and organs in the body. Controlling drug release at the target site, responding to stimuli that originated from internal changes within the body, as well as stimuli manipulated by external sources has recently received significant attention. Owning to the spherical shape and porous structure, dendrimer is utilized as a material for drug delivery. Moreover, the surface region of dendrimer has various moieties facilitating the surface functionalization to develop the desired material. Therefore, multi-stimuli-responsive dendrimers or ‘smart’ dendrimers that respond to more than two stimuli will be an inspired attempt to achieve the site-specific release and reduce as much as possible the side effects of the drug. The aim of this review was to delve much deeper into the recent progress of multi-stimuli-responsive dendrimers in the delivery of anticancer drugs in addition to the major potential challenges. |
| first_indexed | 2024-12-10T07:00:46Z |
| format | Article |
| id | doaj.art-01d70e52fcad4bf9b29e71a6b2b38eb1 |
| institution | Directory Open Access Journal |
| issn | 1999-4923 |
| language | English |
| last_indexed | 2024-12-10T07:00:46Z |
| publishDate | 2019-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Pharmaceutics |
| spelling | doaj.art-01d70e52fcad4bf9b29e71a6b2b38eb12022-12-22T01:58:20ZengMDPI AGPharmaceutics1999-49232019-11-01111159110.3390/pharmaceutics11110591pharmaceutics11110591Recent Progress and Advances of Multi-Stimuli-Responsive Dendrimers in Drug Delivery for Cancer TreatmentNgoc Thuy Trang Le0Thi Nhu Quynh Nguyen1Van Du Cao2Duc Thuan Hoang3Van Cuong Ngo4Thai Thanh Hoang Thi5Institute of Research and Development, Duy Tan University, Danang 550000, VietnamFaculty of Pharmacy, Lac Hong University, Buu Long Ward, Bien Hoa City, Dong Nai Province 810000, VietnamFaculty of Pharmacy, Lac Hong University, Buu Long Ward, Bien Hoa City, Dong Nai Province 810000, VietnamFaculty of Pharmacy, Lac Hong University, Buu Long Ward, Bien Hoa City, Dong Nai Province 810000, VietnamFaculty of Pharmacy, Lac Hong University, Buu Long Ward, Bien Hoa City, Dong Nai Province 810000, VietnamBiomaterials and Nanotechnology Research Group, Faculty of Applied Sciences, Ton Duc Thang University, Ho Chi Minh City 700000, VietnamDespite the fact that nanocarriers as drug delivery systems overcome the limitation of chemotherapy, the leakage of encapsulated drugs during the delivery process to the target site can still cause toxic effects to healthy cells in other tissues and organs in the body. Controlling drug release at the target site, responding to stimuli that originated from internal changes within the body, as well as stimuli manipulated by external sources has recently received significant attention. Owning to the spherical shape and porous structure, dendrimer is utilized as a material for drug delivery. Moreover, the surface region of dendrimer has various moieties facilitating the surface functionalization to develop the desired material. Therefore, multi-stimuli-responsive dendrimers or ‘smart’ dendrimers that respond to more than two stimuli will be an inspired attempt to achieve the site-specific release and reduce as much as possible the side effects of the drug. The aim of this review was to delve much deeper into the recent progress of multi-stimuli-responsive dendrimers in the delivery of anticancer drugs in addition to the major potential challenges.https://www.mdpi.com/1999-4923/11/11/591smart dendrimermulti-stimuli-responsivenessdrug deliverycancer treatment |
| spellingShingle | Ngoc Thuy Trang Le Thi Nhu Quynh Nguyen Van Du Cao Duc Thuan Hoang Van Cuong Ngo Thai Thanh Hoang Thi Recent Progress and Advances of Multi-Stimuli-Responsive Dendrimers in Drug Delivery for Cancer Treatment Pharmaceutics smart dendrimer multi-stimuli-responsiveness drug delivery cancer treatment |
| title | Recent Progress and Advances of Multi-Stimuli-Responsive Dendrimers in Drug Delivery for Cancer Treatment |
| title_full | Recent Progress and Advances of Multi-Stimuli-Responsive Dendrimers in Drug Delivery for Cancer Treatment |
| title_fullStr | Recent Progress and Advances of Multi-Stimuli-Responsive Dendrimers in Drug Delivery for Cancer Treatment |
| title_full_unstemmed | Recent Progress and Advances of Multi-Stimuli-Responsive Dendrimers in Drug Delivery for Cancer Treatment |
| title_short | Recent Progress and Advances of Multi-Stimuli-Responsive Dendrimers in Drug Delivery for Cancer Treatment |
| title_sort | recent progress and advances of multi stimuli responsive dendrimers in drug delivery for cancer treatment |
| topic | smart dendrimer multi-stimuli-responsiveness drug delivery cancer treatment |
| url | https://www.mdpi.com/1999-4923/11/11/591 |
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