Vascular calcification and cardiac function according to residual renal function in patients on hemodialysis with urination.
Vascular calcification is common and may affect cardiac function in patients with end-stage renal disease (ESRD). However, little is known about the effect of residual renal function on vascular calcification and cardiac function in patients on hemodialysis.This study was conducted between January 2...
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2017-01-01
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| Series: | PLoS ONE |
| Online Access: | http://europepmc.org/articles/PMC5617191?pdf=render |
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| author | Dong Ho Shin Young-Ki Lee Jieun Oh Jong-Woo Yoon So Yon Rhee Eun-Jung Kim Jiwon Ryu Ajin Cho Hee Jung Jeon Myung-Jin Choi Jung-Woo Noh |
| author_facet | Dong Ho Shin Young-Ki Lee Jieun Oh Jong-Woo Yoon So Yon Rhee Eun-Jung Kim Jiwon Ryu Ajin Cho Hee Jung Jeon Myung-Jin Choi Jung-Woo Noh |
| author_sort | Dong Ho Shin |
| collection | DOAJ |
| description | Vascular calcification is common and may affect cardiac function in patients with end-stage renal disease (ESRD). However, little is known about the effect of residual renal function on vascular calcification and cardiac function in patients on hemodialysis.This study was conducted between January 2014 and January 2017. One hundred six patients with residual renal function on maintenance hemodialysis for 3 months were recruited. We used residual renal urea clearance (KRU) to measure residual renal function. First, abdominal aortic calcification score (AACS) and brachial-ankle pulse wave velocity (baPWV) were measured in patients on hemodialysis. Second, we performed echocardiography and investigated new cardiovascular events after study enrollment.The median KRU was 0.9 (0.3-2.5) mL/min/1.73m2. AACS (4.0 [1.0-10.0] vs. 3.0 [0.0-8.0], p = 0.05) and baPWV (1836.1 ± 250.4 vs. 1676.8 ± 311.0 cm/s, p = 0.01) were significantly higher in patients with a KRU < 0.9 mL/min/1.73m2 than a KRU ≥ 0.9 mL/min/1.73m2. Log-KRU significantly negatively correlated with log-AACS (ß = -0.29, p = 0.002) and baPWV (ß = -0.19, P = 0.05) after factor adjustment. The proportion of left ventricular diastolic dysfunction was significantly higher in patients with a KRU < 0.9 mL/min/1.73m2 than with a KRU ≥ 0.9 mL/min/1.73m2 (67.9% vs. 49.1%, p = 0.05). Patients with a KRU < 0.9 mL/min/1.73m2 showed a higher tendency of cumulative cardiovascular events compared to those with a KRU ≥ 0.9 ml/min/1.73m2 (P = 0.08).Residual renal function was significantly associated with vascular calcification and left ventricular diastolic dysfunction in patients on hemodialysis. |
| first_indexed | 2024-12-20T14:53:45Z |
| format | Article |
| id | doaj.art-01d75e1ec0274a20b45d7058c270cb11 |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-12-20T14:53:45Z |
| publishDate | 2017-01-01 |
| publisher | Public Library of Science (PLoS) |
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| series | PLoS ONE |
| spelling | doaj.art-01d75e1ec0274a20b45d7058c270cb112022-12-21T19:36:54ZengPublic Library of Science (PLoS)PLoS ONE1932-62032017-01-01129e018529610.1371/journal.pone.0185296Vascular calcification and cardiac function according to residual renal function in patients on hemodialysis with urination.Dong Ho ShinYoung-Ki LeeJieun OhJong-Woo YoonSo Yon RheeEun-Jung KimJiwon RyuAjin ChoHee Jung JeonMyung-Jin ChoiJung-Woo NohVascular calcification is common and may affect cardiac function in patients with end-stage renal disease (ESRD). However, little is known about the effect of residual renal function on vascular calcification and cardiac function in patients on hemodialysis.This study was conducted between January 2014 and January 2017. One hundred six patients with residual renal function on maintenance hemodialysis for 3 months were recruited. We used residual renal urea clearance (KRU) to measure residual renal function. First, abdominal aortic calcification score (AACS) and brachial-ankle pulse wave velocity (baPWV) were measured in patients on hemodialysis. Second, we performed echocardiography and investigated new cardiovascular events after study enrollment.The median KRU was 0.9 (0.3-2.5) mL/min/1.73m2. AACS (4.0 [1.0-10.0] vs. 3.0 [0.0-8.0], p = 0.05) and baPWV (1836.1 ± 250.4 vs. 1676.8 ± 311.0 cm/s, p = 0.01) were significantly higher in patients with a KRU < 0.9 mL/min/1.73m2 than a KRU ≥ 0.9 mL/min/1.73m2. Log-KRU significantly negatively correlated with log-AACS (ß = -0.29, p = 0.002) and baPWV (ß = -0.19, P = 0.05) after factor adjustment. The proportion of left ventricular diastolic dysfunction was significantly higher in patients with a KRU < 0.9 mL/min/1.73m2 than with a KRU ≥ 0.9 mL/min/1.73m2 (67.9% vs. 49.1%, p = 0.05). Patients with a KRU < 0.9 mL/min/1.73m2 showed a higher tendency of cumulative cardiovascular events compared to those with a KRU ≥ 0.9 ml/min/1.73m2 (P = 0.08).Residual renal function was significantly associated with vascular calcification and left ventricular diastolic dysfunction in patients on hemodialysis.http://europepmc.org/articles/PMC5617191?pdf=render |
| spellingShingle | Dong Ho Shin Young-Ki Lee Jieun Oh Jong-Woo Yoon So Yon Rhee Eun-Jung Kim Jiwon Ryu Ajin Cho Hee Jung Jeon Myung-Jin Choi Jung-Woo Noh Vascular calcification and cardiac function according to residual renal function in patients on hemodialysis with urination. PLoS ONE |
| title | Vascular calcification and cardiac function according to residual renal function in patients on hemodialysis with urination. |
| title_full | Vascular calcification and cardiac function according to residual renal function in patients on hemodialysis with urination. |
| title_fullStr | Vascular calcification and cardiac function according to residual renal function in patients on hemodialysis with urination. |
| title_full_unstemmed | Vascular calcification and cardiac function according to residual renal function in patients on hemodialysis with urination. |
| title_short | Vascular calcification and cardiac function according to residual renal function in patients on hemodialysis with urination. |
| title_sort | vascular calcification and cardiac function according to residual renal function in patients on hemodialysis with urination |
| url | http://europepmc.org/articles/PMC5617191?pdf=render |
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