Load matters: neural correlates of verbal working memory in children with autism spectrum disorder
Abstract Background Autism spectrum disorder (ASD) is a pervasive neurodevelopmental disorder characterised by diminished social reciprocity and communication skills and the presence of stereotyped and restricted behaviours. Executive functioning deficits, such as working memory, are associated with...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2018-06-01
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| Series: | Journal of Neurodevelopmental Disorders |
| Subjects: | |
| Online Access: | http://link.springer.com/article/10.1186/s11689-018-9236-y |
| _version_ | 1811220699581251584 |
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| author | Vanessa M. Vogan Kaitlyn E. Francis Benjamin R. Morgan Mary Lou Smith Margot J. Taylor |
| author_facet | Vanessa M. Vogan Kaitlyn E. Francis Benjamin R. Morgan Mary Lou Smith Margot J. Taylor |
| author_sort | Vanessa M. Vogan |
| collection | DOAJ |
| description | Abstract Background Autism spectrum disorder (ASD) is a pervasive neurodevelopmental disorder characterised by diminished social reciprocity and communication skills and the presence of stereotyped and restricted behaviours. Executive functioning deficits, such as working memory, are associated with core ASD symptoms. Working memory allows for temporary storage and manipulation of information and relies heavily on frontal-parietal networks of the brain. There are few reports on the neural correlates of working memory in youth with ASD. The current study identified the neural systems underlying verbal working memory capacity in youth with and without ASD using functional magnetic resonance imaging (fMRI). Methods Fifty-seven youth, 27 with ASD and 30 sex- and age-matched typically developing (TD) controls (9–16 years), completed a one-back letter matching task (LMT) with four levels of difficulty (i.e. cognitive load) while fMRI data were recorded. Linear trend analyses were conducted to examine brain regions that were recruited as a function of increasing cognitive load. Results We found similar behavioural performance on the LMT in terms of reaction times, but in the two higher load conditions, the ASD youth had lower accuracy than the TD group. Neural patterns of activations differed significantly between TD and ASD groups. In TD youth, areas classically used for working memory, including the lateral and medial frontal, as well as superior parietal brain regions, increased in activation with increasing task difficulty, while areas related to the default mode network (DMN) showed decreasing activation (i.e., deactivation). The youth with ASD did not appear to use this opposing cognitive processing system; they showed little recruitment of frontal and parietal regions across the load but did show similar modulation of the DMN. Conclusions In a working memory task, where the load was manipulated without changing executive demands, TD youth showed increasing recruitment with increasing load of the classic fronto-parietal brain areas and decreasing involvement in default mode regions. In contrast, although they modulated the default mode network, youth with ASD did not show the modulation of increasing brain activation with increasing load, suggesting that they may be unable to manage increasing verbal information. Impaired verbal working memory in ASD would interfere with the youths’ success academically and socially. Thus, determining the nature of atypical neural processing could help establish or monitor working memory interventions for ASD. |
| first_indexed | 2024-04-12T07:47:17Z |
| format | Article |
| id | doaj.art-01d7767f6324466c868a8b850ae947b1 |
| institution | Directory Open Access Journal |
| issn | 1866-1947 1866-1955 |
| language | English |
| last_indexed | 2024-04-12T07:47:17Z |
| publishDate | 2018-06-01 |
| publisher | BMC |
| record_format | Article |
| series | Journal of Neurodevelopmental Disorders |
| spelling | doaj.art-01d7767f6324466c868a8b850ae947b12022-12-22T03:41:41ZengBMCJournal of Neurodevelopmental Disorders1866-19471866-19552018-06-0110111210.1186/s11689-018-9236-yLoad matters: neural correlates of verbal working memory in children with autism spectrum disorderVanessa M. Vogan0Kaitlyn E. Francis1Benjamin R. Morgan2Mary Lou Smith3Margot J. Taylor4Diagnostic Imaging & Research Institute, Hospital for Sick ChildrenDiagnostic Imaging & Research Institute, Hospital for Sick ChildrenDiagnostic Imaging & Research Institute, Hospital for Sick ChildrenDepartment of Psychology, University of TorontoDiagnostic Imaging & Research Institute, Hospital for Sick ChildrenAbstract Background Autism spectrum disorder (ASD) is a pervasive neurodevelopmental disorder characterised by diminished social reciprocity and communication skills and the presence of stereotyped and restricted behaviours. Executive functioning deficits, such as working memory, are associated with core ASD symptoms. Working memory allows for temporary storage and manipulation of information and relies heavily on frontal-parietal networks of the brain. There are few reports on the neural correlates of working memory in youth with ASD. The current study identified the neural systems underlying verbal working memory capacity in youth with and without ASD using functional magnetic resonance imaging (fMRI). Methods Fifty-seven youth, 27 with ASD and 30 sex- and age-matched typically developing (TD) controls (9–16 years), completed a one-back letter matching task (LMT) with four levels of difficulty (i.e. cognitive load) while fMRI data were recorded. Linear trend analyses were conducted to examine brain regions that were recruited as a function of increasing cognitive load. Results We found similar behavioural performance on the LMT in terms of reaction times, but in the two higher load conditions, the ASD youth had lower accuracy than the TD group. Neural patterns of activations differed significantly between TD and ASD groups. In TD youth, areas classically used for working memory, including the lateral and medial frontal, as well as superior parietal brain regions, increased in activation with increasing task difficulty, while areas related to the default mode network (DMN) showed decreasing activation (i.e., deactivation). The youth with ASD did not appear to use this opposing cognitive processing system; they showed little recruitment of frontal and parietal regions across the load but did show similar modulation of the DMN. Conclusions In a working memory task, where the load was manipulated without changing executive demands, TD youth showed increasing recruitment with increasing load of the classic fronto-parietal brain areas and decreasing involvement in default mode regions. In contrast, although they modulated the default mode network, youth with ASD did not show the modulation of increasing brain activation with increasing load, suggesting that they may be unable to manage increasing verbal information. Impaired verbal working memory in ASD would interfere with the youths’ success academically and socially. Thus, determining the nature of atypical neural processing could help establish or monitor working memory interventions for ASD.http://link.springer.com/article/10.1186/s11689-018-9236-yAutism spectrum disorderVerbal working memoryCognitive loadExecutive functioningfMRI |
| spellingShingle | Vanessa M. Vogan Kaitlyn E. Francis Benjamin R. Morgan Mary Lou Smith Margot J. Taylor Load matters: neural correlates of verbal working memory in children with autism spectrum disorder Journal of Neurodevelopmental Disorders Autism spectrum disorder Verbal working memory Cognitive load Executive functioning fMRI |
| title | Load matters: neural correlates of verbal working memory in children with autism spectrum disorder |
| title_full | Load matters: neural correlates of verbal working memory in children with autism spectrum disorder |
| title_fullStr | Load matters: neural correlates of verbal working memory in children with autism spectrum disorder |
| title_full_unstemmed | Load matters: neural correlates of verbal working memory in children with autism spectrum disorder |
| title_short | Load matters: neural correlates of verbal working memory in children with autism spectrum disorder |
| title_sort | load matters neural correlates of verbal working memory in children with autism spectrum disorder |
| topic | Autism spectrum disorder Verbal working memory Cognitive load Executive functioning fMRI |
| url | http://link.springer.com/article/10.1186/s11689-018-9236-y |
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