COVID-19 in kidney transplant recipients: what have we learned one year later? A cohort study from a tertiary center
Abstract Introduction: Kidney transplant (KT) recipients have a high risk for adverse outcomes from infections, such as COVID-19. Methods: We have retrospectively reviewed all KT recipients with documented COVID-19 between March 1, 2020, and March 15, 2021, and analyzed patients’ characteristics,...
| Main Authors: | , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Sociedade Brasileira de Nefrologia
2022-07-01
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| Series: | Brazilian Journal of Nephrology |
| Subjects: | |
| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0101-28002022005035402&lng=en&tlng=en |
| _version_ | 1811324163011379200 |
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| author | Joana Tavares João Pedro Oliveira Pedro Reis Bárbara Ribeiro Filipa Silva Jorge Malheiro Manuela Almeida La Salete Martins António Cabrita António Castro Henriques Leonídio Dias |
| author_facet | Joana Tavares João Pedro Oliveira Pedro Reis Bárbara Ribeiro Filipa Silva Jorge Malheiro Manuela Almeida La Salete Martins António Cabrita António Castro Henriques Leonídio Dias |
| author_sort | Joana Tavares |
| collection | DOAJ |
| description | Abstract Introduction: Kidney transplant (KT) recipients have a high risk for adverse outcomes from infections, such as COVID-19. Methods: We have retrospectively reviewed all KT recipients with documented COVID-19 between March 1, 2020, and March 15, 2021, and analyzed patients’ characteristics, clinical course, treatment, and outcomes. Results: We identified 123 patients, 72% were male, with a mean age of 54.5±13.0 years. Twenty percent were asymptomatic, 7% had a nosocomial transmission, and 36% of the remainder required hospitalization. Almost all admitted patients received oxygen, 30% required invasive mechanical ventilation (IMV), more than a half had acute kidney injury, with 10% requiring dialysis, and 20% died. Incidence was comparable to that of the Portuguese population, but the mortality rate was almost four times higher (SMR of 3.768 (95% CI:1.723-7.154). Higher body mass index (OR 1.275, P=0.001), lower baseline graft function (OR 0.968, P=0.015), and nosocomial transmission (OR 13.836, P=0.019) were associated with oxygen demand, whereas female gender (OR 3.801, P=0.031) and lower baseline kidney graft function (OR 0.955, P=0.005), but not body mass index, were associated with IMV and/or death. Conclusion: Mortality rate in KT patients was higher than in the general population and lower baseline kidney function was the most consistent marker for adverse outcomes. |
| first_indexed | 2024-04-13T14:09:24Z |
| format | Article |
| id | doaj.art-01d7a36ae92c45cf849f4498add9c48f |
| institution | Directory Open Access Journal |
| issn | 2175-8239 |
| language | English |
| last_indexed | 2024-04-13T14:09:24Z |
| publishDate | 2022-07-01 |
| publisher | Sociedade Brasileira de Nefrologia |
| record_format | Article |
| series | Brazilian Journal of Nephrology |
| spelling | doaj.art-01d7a36ae92c45cf849f4498add9c48f2022-12-22T02:43:50ZengSociedade Brasileira de NefrologiaBrazilian Journal of Nephrology2175-82392022-07-0110.1590/2175-8239-jbn-2021-0257enCOVID-19 in kidney transplant recipients: what have we learned one year later? A cohort study from a tertiary centerJoana Tavareshttps://orcid.org/0000-0002-3776-4923João Pedro Oliveirahttps://orcid.org/0000-0002-7465-1469Pedro ReisBárbara RibeiroFilipa Silvahttps://orcid.org/0000-0002-7818-6453Jorge MalheiroManuela AlmeidaLa Salete MartinsAntónio CabritaAntónio Castro HenriquesLeonídio DiasAbstract Introduction: Kidney transplant (KT) recipients have a high risk for adverse outcomes from infections, such as COVID-19. Methods: We have retrospectively reviewed all KT recipients with documented COVID-19 between March 1, 2020, and March 15, 2021, and analyzed patients’ characteristics, clinical course, treatment, and outcomes. Results: We identified 123 patients, 72% were male, with a mean age of 54.5±13.0 years. Twenty percent were asymptomatic, 7% had a nosocomial transmission, and 36% of the remainder required hospitalization. Almost all admitted patients received oxygen, 30% required invasive mechanical ventilation (IMV), more than a half had acute kidney injury, with 10% requiring dialysis, and 20% died. Incidence was comparable to that of the Portuguese population, but the mortality rate was almost four times higher (SMR of 3.768 (95% CI:1.723-7.154). Higher body mass index (OR 1.275, P=0.001), lower baseline graft function (OR 0.968, P=0.015), and nosocomial transmission (OR 13.836, P=0.019) were associated with oxygen demand, whereas female gender (OR 3.801, P=0.031) and lower baseline kidney graft function (OR 0.955, P=0.005), but not body mass index, were associated with IMV and/or death. Conclusion: Mortality rate in KT patients was higher than in the general population and lower baseline kidney function was the most consistent marker for adverse outcomes.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0101-28002022005035402&lng=en&tlng=enAcute Kidney InjuryRenal Insufficiency, ChronicCOVID-19Immunosuppression; Kidney Transplantation |
| spellingShingle | Joana Tavares João Pedro Oliveira Pedro Reis Bárbara Ribeiro Filipa Silva Jorge Malheiro Manuela Almeida La Salete Martins António Cabrita António Castro Henriques Leonídio Dias COVID-19 in kidney transplant recipients: what have we learned one year later? A cohort study from a tertiary center Brazilian Journal of Nephrology Acute Kidney Injury Renal Insufficiency, Chronic COVID-19 Immunosuppression; Kidney Transplantation |
| title | COVID-19 in kidney transplant recipients: what have we learned one year later? A cohort study from a tertiary center |
| title_full | COVID-19 in kidney transplant recipients: what have we learned one year later? A cohort study from a tertiary center |
| title_fullStr | COVID-19 in kidney transplant recipients: what have we learned one year later? A cohort study from a tertiary center |
| title_full_unstemmed | COVID-19 in kidney transplant recipients: what have we learned one year later? A cohort study from a tertiary center |
| title_short | COVID-19 in kidney transplant recipients: what have we learned one year later? A cohort study from a tertiary center |
| title_sort | covid 19 in kidney transplant recipients what have we learned one year later a cohort study from a tertiary center |
| topic | Acute Kidney Injury Renal Insufficiency, Chronic COVID-19 Immunosuppression; Kidney Transplantation |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0101-28002022005035402&lng=en&tlng=en |
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