RNA demethylase ALKBH5 prevents pancreatic cancer progression by posttranscriptional activation of PER1 in an m6A-YTHDF2-dependent manner

RNA demethylase ALKBH5 prevents pancreatic cancer progression by posttranscriptional activation of PER1 in an m6A-YTHDF2-dependent manner

Abstract Background N6-methyladenosine (m6A) is the most abundant reversible methylation modification of eukaryotic mRNA, and it plays vital roles in tumourigenesis. This study aimed to explore the role of the m6A demethylase ALKBH5 in pancreatic cancer (PC). Methods The expression of ALKBH5 and its...

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Bibliographic Details
Main Authors: Xingya Guo, Kai Li, Weiliang Jiang, Yangyang Hu, Wenqin Xiao, Yinshi Huang, Yun Feng, Qin Pan, Rong Wan
Format: Article
Language:English
Published: BMC 2020-05-01
Series:Molecular Cancer
Subjects:
Pancreatic cancer
m6A
ALKBH5
PER1
Online Access:http://link.springer.com/article/10.1186/s12943-020-01158-w

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