CRISPR/Cas9-engineered Drosophila knock-in models to study VCP diseases

CRISPR/Cas9-engineered Drosophila knock-in models to study VCP diseases

Mutations in Valosin Containing Protein (VCP) are associated with several degenerative diseases, including multisystem proteinopathy (MSP-1) and amyotrophic lateral sclerosis. However, patients with VCP mutations vary widely in their pathology and clinical penetrance, making it difficult to devise e...

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Bibliographic Details
Main Authors: Jordan M. Wall, Ankita Basu, Elizabeth R. M. Zunica, Olga S. Dubuisson, Kathryn Pergola, Joshua P. Broussard, John P. Kirwan, Christopher L. Axelrod, Alyssa E. Johnson
Format: Article
Language:English
Published: The Company of Biologists 2021-07-01
Series:Disease Models & Mechanisms
Subjects:
drosophila
ibmpfd
lysosomes
ter94
vcp
mitochondria
msp-1
Online Access:http://dmm.biologists.org/content/14/7/dmm048603

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