Oral and gut microbial profiling in periodontitis and Parkinson’s disease
Objectives We tested the hypothesis that Parkinson’s disease (PA) alters the periodontitis-associated oral microbiome.Method Patients with periodontitis with Parkinson’s disease (PA+P) and without PA (P) and systemically and periodontally healthy individuals (HC) were enrolled. Clinical, periodontal...
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2024-12-01
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| Series: | Journal of Oral Microbiology |
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| Online Access: | https://www.tandfonline.com/doi/10.1080/20002297.2024.2331264 |
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| author | Ekin Yay Melis Yilmaz Hilal Toygar Nur Balci Carla Alvarez Rivas Basak Bolluk Kılıç Ali Zirh Bruce J. Paster Alpdogan Kantarci |
| author_facet | Ekin Yay Melis Yilmaz Hilal Toygar Nur Balci Carla Alvarez Rivas Basak Bolluk Kılıç Ali Zirh Bruce J. Paster Alpdogan Kantarci |
| author_sort | Ekin Yay |
| collection | DOAJ |
| description | Objectives We tested the hypothesis that Parkinson’s disease (PA) alters the periodontitis-associated oral microbiome.Method Patients with periodontitis with Parkinson’s disease (PA+P) and without PA (P) and systemically and periodontally healthy individuals (HC) were enrolled. Clinical, periodontal and neurological parameters were recorded. The severity of PA motor functions was measured. Unstimulated saliva samples and stool samples were collected. Next-generation sequencing of 16S ribosomal RNA (V1-V3 regions) was performed.Results PA patients had mild-to-moderate motor dysfunction and comparable plaque scores as those without, indicating that oral hygiene was efficient in the PA+P group. In saliva, there were statistically significant differences in beta diversity between HC and PA+P (p = 0.001), HC and P (p = 0.001), and P and PA+P (p = 0.028). The microbial profiles of saliva and fecal samples were distinct. Mycoplasma faucium, Tannerella forsythia, Parvimonas micra, and Saccharibacteria (TM7) were increased in P; Prevotella pallens, Prevotella melaninogenica, Neisseria multispecies were more abundant in PA+P group, Ruthenibacterium lactatiformans, Dialister succinatiphilus, Butyrivibrio crossotus and Alloprevotella tannerae were detected in fecal samples in P groups compared to healthy controls.Conclusions No significant differences were detected between Parkinson’s and non-Parkinson’s gut microbiomes, suggesting that Parkinson’s disease modifies the oral microbiome in periodontitis subjects independent of the gut microbiome. |
| first_indexed | 2024-04-24T21:40:03Z |
| format | Article |
| id | doaj.art-01d9226d25c64c6f9a837060e333bee7 |
| institution | Directory Open Access Journal |
| issn | 2000-2297 |
| language | English |
| last_indexed | 2025-02-18T02:34:36Z |
| publishDate | 2024-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Journal of Oral Microbiology |
| spelling | doaj.art-01d9226d25c64c6f9a837060e333bee72024-11-26T06:52:11ZengTaylor & Francis GroupJournal of Oral Microbiology2000-22972024-12-0116110.1080/20002297.2024.2331264Oral and gut microbial profiling in periodontitis and Parkinson’s diseaseEkin Yay0Melis Yilmaz1Hilal Toygar2Nur Balci3Carla Alvarez Rivas4Basak Bolluk Kılıç5Ali Zirh6Bruce J. Paster7Alpdogan Kantarci8Department of Applied Oral Sciences, The ADA Forsyth Institute, Cambridge, MA, USADepartment of Applied Oral Sciences, The ADA Forsyth Institute, Cambridge, MA, USADepartment of Periodontology, Istanbul Medipol University, Istanbul, TurkeyDepartment of Periodontology, Istanbul Medipol University, Istanbul, TurkeyDepartment of Applied Oral Sciences, The ADA Forsyth Institute, Cambridge, MA, USADepartment of Neurology, Istanbul Medipol University, Istanbul, TurkeyDepartment of Neurology, Istanbul Medipol University, Istanbul, TurkeyDepartment of Applied Oral Sciences, The ADA Forsyth Institute, Cambridge, MA, USADepartment of Applied Oral Sciences, The ADA Forsyth Institute, Cambridge, MA, USAObjectives We tested the hypothesis that Parkinson’s disease (PA) alters the periodontitis-associated oral microbiome.Method Patients with periodontitis with Parkinson’s disease (PA+P) and without PA (P) and systemically and periodontally healthy individuals (HC) were enrolled. Clinical, periodontal and neurological parameters were recorded. The severity of PA motor functions was measured. Unstimulated saliva samples and stool samples were collected. Next-generation sequencing of 16S ribosomal RNA (V1-V3 regions) was performed.Results PA patients had mild-to-moderate motor dysfunction and comparable plaque scores as those without, indicating that oral hygiene was efficient in the PA+P group. In saliva, there were statistically significant differences in beta diversity between HC and PA+P (p = 0.001), HC and P (p = 0.001), and P and PA+P (p = 0.028). The microbial profiles of saliva and fecal samples were distinct. Mycoplasma faucium, Tannerella forsythia, Parvimonas micra, and Saccharibacteria (TM7) were increased in P; Prevotella pallens, Prevotella melaninogenica, Neisseria multispecies were more abundant in PA+P group, Ruthenibacterium lactatiformans, Dialister succinatiphilus, Butyrivibrio crossotus and Alloprevotella tannerae were detected in fecal samples in P groups compared to healthy controls.Conclusions No significant differences were detected between Parkinson’s and non-Parkinson’s gut microbiomes, suggesting that Parkinson’s disease modifies the oral microbiome in periodontitis subjects independent of the gut microbiome.https://www.tandfonline.com/doi/10.1080/20002297.2024.2331264PeriodontitisParkinson’s diseasemicrobiomenext-generation sequencingpathogenesis |
| spellingShingle | Ekin Yay Melis Yilmaz Hilal Toygar Nur Balci Carla Alvarez Rivas Basak Bolluk Kılıç Ali Zirh Bruce J. Paster Alpdogan Kantarci Oral and gut microbial profiling in periodontitis and Parkinson’s disease Journal of Oral Microbiology Periodontitis Parkinson’s disease microbiome next-generation sequencing pathogenesis |
| title | Oral and gut microbial profiling in periodontitis and Parkinson’s disease |
| title_full | Oral and gut microbial profiling in periodontitis and Parkinson’s disease |
| title_fullStr | Oral and gut microbial profiling in periodontitis and Parkinson’s disease |
| title_full_unstemmed | Oral and gut microbial profiling in periodontitis and Parkinson’s disease |
| title_short | Oral and gut microbial profiling in periodontitis and Parkinson’s disease |
| title_sort | oral and gut microbial profiling in periodontitis and parkinson s disease |
| topic | Periodontitis Parkinson’s disease microbiome next-generation sequencing pathogenesis |
| url | https://www.tandfonline.com/doi/10.1080/20002297.2024.2331264 |
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