Association of mitochondrial DNA polymorphisms and/or haplogroups with elite Japanese athlete status
A number of familial and twin studies have assessed the relative contribution of genetic and environmental factors to physical performance or its-related traits and have estimated that there is a significant genetic component to their phenotypes. In addition, aerobic capacity has been found to have...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Japanese Society of Physical Fitness and Sports Medicine
2013-04-01
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| Series: | Journal of Physical Fitness and Sports Medicine |
| Subjects: | |
| Online Access: | https://www.jstage.jst.go.jp/article/jpfsm/2/1/2_17/_pdf/-char/en |
| _version_ | 1818596674446032896 |
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| author | Noriyuki Fuku Eri Mikami Masashi Tanaka |
| author_facet | Noriyuki Fuku Eri Mikami Masashi Tanaka |
| author_sort | Noriyuki Fuku |
| collection | DOAJ |
| description | A number of familial and twin studies have assessed the relative contribution of genetic and environmental factors to physical performance or its-related traits and have estimated that there is a significant genetic component to their phenotypes. In addition, aerobic capacity has been found to have stronger maternal inheritance than paternal. This finding implies that functional differences in maternally inherited mtDNA-encoded proteins involved in oxidative phosphorylation affect aerobic performance. In this article, therefore, we focus on associations between mtDNA polymorphisms/haplogroups and elite Japanese athlete status. From sequencing analysis of the control region in the mtDNA, certain mtDNA polymorphisms and haplogroups were shown to be associated with elite Japanese endurance athlete status, probably due to enhanced ATP production by mitochondria in the cardiac and skeletal muscles or both. This phenomenon is in agreement with several previous reports on Caucasian and African populations. It should be noted that certain mtDNA polymorphisms or haplogroups are also associated with elite Japanese sprint athlete/power status, probably due to enhanced calcium dynamics in the skeletal muscle. Thus, mtDNA polymorphisms/haplogroups influence not only aerobic performance but also anaerobic performance. |
| first_indexed | 2024-12-16T11:35:40Z |
| format | Article |
| id | doaj.art-01dccc781b1c4b749169d0677f2b6b5d |
| institution | Directory Open Access Journal |
| issn | 2186-8131 2186-8123 |
| language | English |
| last_indexed | 2024-12-16T11:35:40Z |
| publishDate | 2013-04-01 |
| publisher | Japanese Society of Physical Fitness and Sports Medicine |
| record_format | Article |
| series | Journal of Physical Fitness and Sports Medicine |
| spelling | doaj.art-01dccc781b1c4b749169d0677f2b6b5d2022-12-21T22:33:06ZengJapanese Society of Physical Fitness and Sports MedicineJournal of Physical Fitness and Sports Medicine2186-81312186-81232013-04-0121172710.7600/jpfsm.2.17jpfsmAssociation of mitochondrial DNA polymorphisms and/or haplogroups with elite Japanese athlete statusNoriyuki Fuku0Eri Mikami1Masashi Tanaka2Department of Genomics for Longevity and Health, Tokyo Metropolitan Institute of GerontologyDepartment of Genomics for Longevity and Health, Tokyo Metropolitan Institute of GerontologyDepartment of Genomics for Longevity and Health, Tokyo Metropolitan Institute of GerontologyA number of familial and twin studies have assessed the relative contribution of genetic and environmental factors to physical performance or its-related traits and have estimated that there is a significant genetic component to their phenotypes. In addition, aerobic capacity has been found to have stronger maternal inheritance than paternal. This finding implies that functional differences in maternally inherited mtDNA-encoded proteins involved in oxidative phosphorylation affect aerobic performance. In this article, therefore, we focus on associations between mtDNA polymorphisms/haplogroups and elite Japanese athlete status. From sequencing analysis of the control region in the mtDNA, certain mtDNA polymorphisms and haplogroups were shown to be associated with elite Japanese endurance athlete status, probably due to enhanced ATP production by mitochondria in the cardiac and skeletal muscles or both. This phenomenon is in agreement with several previous reports on Caucasian and African populations. It should be noted that certain mtDNA polymorphisms or haplogroups are also associated with elite Japanese sprint athlete/power status, probably due to enhanced calcium dynamics in the skeletal muscle. Thus, mtDNA polymorphisms/haplogroups influence not only aerobic performance but also anaerobic performance.https://www.jstage.jst.go.jp/article/jpfsm/2/1/2_17/_pdf/-char/enmitochondrial dnahaplogrouppolymorphismathlete statusphysical performanceendurancesprint |
| spellingShingle | Noriyuki Fuku Eri Mikami Masashi Tanaka Association of mitochondrial DNA polymorphisms and/or haplogroups with elite Japanese athlete status Journal of Physical Fitness and Sports Medicine mitochondrial dna haplogroup polymorphism athlete status physical performance endurance sprint |
| title | Association of mitochondrial DNA polymorphisms and/or haplogroups with elite Japanese athlete status |
| title_full | Association of mitochondrial DNA polymorphisms and/or haplogroups with elite Japanese athlete status |
| title_fullStr | Association of mitochondrial DNA polymorphisms and/or haplogroups with elite Japanese athlete status |
| title_full_unstemmed | Association of mitochondrial DNA polymorphisms and/or haplogroups with elite Japanese athlete status |
| title_short | Association of mitochondrial DNA polymorphisms and/or haplogroups with elite Japanese athlete status |
| title_sort | association of mitochondrial dna polymorphisms and or haplogroups with elite japanese athlete status |
| topic | mitochondrial dna haplogroup polymorphism athlete status physical performance endurance sprint |
| url | https://www.jstage.jst.go.jp/article/jpfsm/2/1/2_17/_pdf/-char/en |
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