High-resolution tandem mass spectrometry dataset reveals fragmentation patterns of cardiac glycosides in leaves of the foxglove plants
Cardiac glycosides, steroid derivatives extracted from the foxglove plants, have been used for the treatment of heart failure since the 18th century. A method based on liquid chromatography coupled with high-resolution tandem mass spectrometry (LC/MS2) has been developed to characterize and quantify...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2020-06-01
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| Series: | Data in Brief |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2352340920303589 |
| _version_ | 1818507546031292416 |
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| author | Baradwaj Gopal Ravi Mary Grace E. Guardian Rebecca Dickman Zhen Q. Wang |
| author_facet | Baradwaj Gopal Ravi Mary Grace E. Guardian Rebecca Dickman Zhen Q. Wang |
| author_sort | Baradwaj Gopal Ravi |
| collection | DOAJ |
| description | Cardiac glycosides, steroid derivatives extracted from the foxglove plants, have been used for the treatment of heart failure since the 18th century. A method based on liquid chromatography coupled with high-resolution tandem mass spectrometry (LC/MS2) has been developed to characterize and quantify cardiac glycosides in fresh-leaf extracts of the foxglove (Digitalis sp.) plants [1]. In this report, the fragmentation spectra of additional authentic standards of cardiac glycoside (digitoxigenin, digoxigenin, β-acetyldigoxin) and cardenolides identified in the leaves of Digitalis lanata (D. lanata) and Digitalis purpurea (D. purpurea) were provided with high resolution. The exact mass of signature peaks for the aglycones and the sugar units of cardenolides were measured. This dataset is valuable to researchers interested in characterizing cardenolides in plants, or quantifying cardenolides in drug tablets, or studying cardenolide toxicities in animals. The fragmentation patterns of authentic cardenolide standards provided in these data can be used to validate relevant cardenolides in various biological samples and to infer chemical structures of unknown cardiac glycosides. |
| first_indexed | 2024-12-10T22:19:56Z |
| format | Article |
| id | doaj.art-01dd93af0374400ea1a7da84f4276774 |
| institution | Directory Open Access Journal |
| issn | 2352-3409 |
| language | English |
| last_indexed | 2024-12-10T22:19:56Z |
| publishDate | 2020-06-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Data in Brief |
| spelling | doaj.art-01dd93af0374400ea1a7da84f42767742022-12-22T01:31:20ZengElsevierData in Brief2352-34092020-06-0130105464High-resolution tandem mass spectrometry dataset reveals fragmentation patterns of cardiac glycosides in leaves of the foxglove plantsBaradwaj Gopal Ravi0Mary Grace E. Guardian1Rebecca Dickman2Zhen Q. Wang3Department of Biological Sciences, University at Buffalo, State University of New York, Buffalo, NY 14260, United StatesDepartment of Chemistry, Chemistry Instrumentation Center, University at Buffalo, State University of New York, Buffalo, NY 14260, United StatesDepartment of Chemistry, Chemistry Instrumentation Center, University at Buffalo, State University of New York, Buffalo, NY 14260, United StatesDepartment of Biological Sciences, University at Buffalo, State University of New York, Buffalo, NY 14260, United States; Corresponding author.Cardiac glycosides, steroid derivatives extracted from the foxglove plants, have been used for the treatment of heart failure since the 18th century. A method based on liquid chromatography coupled with high-resolution tandem mass spectrometry (LC/MS2) has been developed to characterize and quantify cardiac glycosides in fresh-leaf extracts of the foxglove (Digitalis sp.) plants [1]. In this report, the fragmentation spectra of additional authentic standards of cardiac glycoside (digitoxigenin, digoxigenin, β-acetyldigoxin) and cardenolides identified in the leaves of Digitalis lanata (D. lanata) and Digitalis purpurea (D. purpurea) were provided with high resolution. The exact mass of signature peaks for the aglycones and the sugar units of cardenolides were measured. This dataset is valuable to researchers interested in characterizing cardenolides in plants, or quantifying cardenolides in drug tablets, or studying cardenolide toxicities in animals. The fragmentation patterns of authentic cardenolide standards provided in these data can be used to validate relevant cardenolides in various biological samples and to infer chemical structures of unknown cardiac glycosides.http://www.sciencedirect.com/science/article/pii/S2352340920303589CardenolidesDigitalis purpureaDigitalis lanataDigoxinDigitoxinHeart failure |
| spellingShingle | Baradwaj Gopal Ravi Mary Grace E. Guardian Rebecca Dickman Zhen Q. Wang High-resolution tandem mass spectrometry dataset reveals fragmentation patterns of cardiac glycosides in leaves of the foxglove plants Data in Brief Cardenolides Digitalis purpurea Digitalis lanata Digoxin Digitoxin Heart failure |
| title | High-resolution tandem mass spectrometry dataset reveals fragmentation patterns of cardiac glycosides in leaves of the foxglove plants |
| title_full | High-resolution tandem mass spectrometry dataset reveals fragmentation patterns of cardiac glycosides in leaves of the foxglove plants |
| title_fullStr | High-resolution tandem mass spectrometry dataset reveals fragmentation patterns of cardiac glycosides in leaves of the foxglove plants |
| title_full_unstemmed | High-resolution tandem mass spectrometry dataset reveals fragmentation patterns of cardiac glycosides in leaves of the foxglove plants |
| title_short | High-resolution tandem mass spectrometry dataset reveals fragmentation patterns of cardiac glycosides in leaves of the foxglove plants |
| title_sort | high resolution tandem mass spectrometry dataset reveals fragmentation patterns of cardiac glycosides in leaves of the foxglove plants |
| topic | Cardenolides Digitalis purpurea Digitalis lanata Digoxin Digitoxin Heart failure |
| url | http://www.sciencedirect.com/science/article/pii/S2352340920303589 |
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