Protective Effect of Aerobic Exercise against Some of Proinflammatory Cytokines-Induced Chronic Nitric Oxide Synthase Inhibition in Renal Tissue Rats
BACKGROUND AND OBJECTIVE: Hypertension is associated with alteration in endothelial function mediated through reduced nitric oxide bioavailability and renal injury. Exercise training has been shown to improve endothelial function in animal models of hypertension and in the patients with essential hy...
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| Format: | Article |
| Language: | English |
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Babol University of Medical Sciences
2013-01-01
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| Series: | Majallah-i Dānishgāh-i ̒Ulūm-i Pizishkī-i Bābul |
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| Online Access: | http://jbums.org/article-1-4306-en.html |
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| author | M Habibian, M Peeri MA Azarbayjani, M Hedayati |
| author_facet | M Habibian, M Peeri MA Azarbayjani, M Hedayati |
| author_sort | M Habibian, |
| collection | DOAJ |
| description | BACKGROUND AND OBJECTIVE: Hypertension is associated with alteration in endothelial function mediated through reduced nitric oxide bioavailability and renal injury. Exercise training has been shown to improve endothelial function in animal models of hypertension and in the patients with essential hypertension. The purpose of this study was to investigate the protective effect of aerobic exercise against some of proinflammatory cytokines in the renal tissue of rats treated with chronic nitric oxide synthase inhibition. METHODS: In this experimental research, 40 male Wistar rats were randomly divided into four groups: (1) control (2) sham (3) nitric oxide synthase inhibition (infusion of N?-Nitro-L-Arginine Methyl Ester, intraperitoneally) and (4) aerobic exercise (exercise + nitric oxide synthase inhibition) (n=10 for any group). The exercise consisted of progressive running training on the treadmill for 15 to 22 m/min, 25 to 64 min /day, and 5 days/week for 8 weeks. Tumor necrosis factor-alpha (TNF-?) and interlukin-6 (IL-6) levels was measured by ELISA method and the groups were compared.FINDINGS: Chronic nitric oxide synthase inhibition significantly enhanced renal TNF-? (2.53 ± 0.52 pg/mg) and IL-6 (4.15 ± 0.88 pg/mg) levels (p=0.000). Conversely, aerobic exercise significantly decreased (p=0.045) this proinflammatory cytokines levels (1.97 ± 0.37, 3.46 ± 0.80 pg/mg, respectively) in rat kidney.CONCLUSION: Regular aerobic exercise with moderate intense may exert protective role against systemic nitric oxide deficiency-induced inflammatory renal injury by down-regulating the proinflammatory cytokines. |
| first_indexed | 2024-12-22T04:05:22Z |
| format | Article |
| id | doaj.art-01e011c584d242e99bd5a4629ec77e10 |
| institution | Directory Open Access Journal |
| issn | 1561-4107 2251-7170 |
| language | English |
| last_indexed | 2024-12-22T04:05:22Z |
| publishDate | 2013-01-01 |
| publisher | Babol University of Medical Sciences |
| record_format | Article |
| series | Majallah-i Dānishgāh-i ̒Ulūm-i Pizishkī-i Bābul |
| spelling | doaj.art-01e011c584d242e99bd5a4629ec77e102022-12-21T18:39:38ZengBabol University of Medical SciencesMajallah-i Dānishgāh-i ̒Ulūm-i Pizishkī-i Bābul1561-41072251-71702013-01-011513037Protective Effect of Aerobic Exercise against Some of Proinflammatory Cytokines-Induced Chronic Nitric Oxide Synthase Inhibition in Renal Tissue RatsM Habibian,0M Peeri1MA Azarbayjani,2M Hedayati3 BACKGROUND AND OBJECTIVE: Hypertension is associated with alteration in endothelial function mediated through reduced nitric oxide bioavailability and renal injury. Exercise training has been shown to improve endothelial function in animal models of hypertension and in the patients with essential hypertension. The purpose of this study was to investigate the protective effect of aerobic exercise against some of proinflammatory cytokines in the renal tissue of rats treated with chronic nitric oxide synthase inhibition. METHODS: In this experimental research, 40 male Wistar rats were randomly divided into four groups: (1) control (2) sham (3) nitric oxide synthase inhibition (infusion of N?-Nitro-L-Arginine Methyl Ester, intraperitoneally) and (4) aerobic exercise (exercise + nitric oxide synthase inhibition) (n=10 for any group). The exercise consisted of progressive running training on the treadmill for 15 to 22 m/min, 25 to 64 min /day, and 5 days/week for 8 weeks. Tumor necrosis factor-alpha (TNF-?) and interlukin-6 (IL-6) levels was measured by ELISA method and the groups were compared.FINDINGS: Chronic nitric oxide synthase inhibition significantly enhanced renal TNF-? (2.53 ± 0.52 pg/mg) and IL-6 (4.15 ± 0.88 pg/mg) levels (p=0.000). Conversely, aerobic exercise significantly decreased (p=0.045) this proinflammatory cytokines levels (1.97 ± 0.37, 3.46 ± 0.80 pg/mg, respectively) in rat kidney.CONCLUSION: Regular aerobic exercise with moderate intense may exert protective role against systemic nitric oxide deficiency-induced inflammatory renal injury by down-regulating the proinflammatory cytokines.http://jbums.org/article-1-4306-en.htmlProinflammatory cytokinesNitric oxideExercise training |
| spellingShingle | M Habibian, M Peeri MA Azarbayjani, M Hedayati Protective Effect of Aerobic Exercise against Some of Proinflammatory Cytokines-Induced Chronic Nitric Oxide Synthase Inhibition in Renal Tissue Rats Majallah-i Dānishgāh-i ̒Ulūm-i Pizishkī-i Bābul Proinflammatory cytokines Nitric oxide Exercise training |
| title | Protective Effect of Aerobic Exercise against Some of Proinflammatory Cytokines-Induced Chronic Nitric Oxide Synthase Inhibition in Renal Tissue Rats |
| title_full | Protective Effect of Aerobic Exercise against Some of Proinflammatory Cytokines-Induced Chronic Nitric Oxide Synthase Inhibition in Renal Tissue Rats |
| title_fullStr | Protective Effect of Aerobic Exercise against Some of Proinflammatory Cytokines-Induced Chronic Nitric Oxide Synthase Inhibition in Renal Tissue Rats |
| title_full_unstemmed | Protective Effect of Aerobic Exercise against Some of Proinflammatory Cytokines-Induced Chronic Nitric Oxide Synthase Inhibition in Renal Tissue Rats |
| title_short | Protective Effect of Aerobic Exercise against Some of Proinflammatory Cytokines-Induced Chronic Nitric Oxide Synthase Inhibition in Renal Tissue Rats |
| title_sort | protective effect of aerobic exercise against some of proinflammatory cytokines induced chronic nitric oxide synthase inhibition in renal tissue rats |
| topic | Proinflammatory cytokines Nitric oxide Exercise training |
| url | http://jbums.org/article-1-4306-en.html |
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