An enriched maternal environment and stereotypies of sows differentially affect the neuro-epigenome of brain regions related to emotionality in their piglets
Epigenetic mechanisms are important modulators of neurodevelopmental outcomes in the offspring of animals challenged during pregnancy. Pregnant sows living in a confined environment are challenged with stress and lack of stimulation which may result in the expression of stereotypies (repetitive beha...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2023-12-01
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| Series: | Epigenetics |
| Subjects: | |
| Online Access: | http://dx.doi.org/10.1080/15592294.2023.2196656 |
| _version_ | 1797678794148937728 |
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| author | Patricia Tatemoto Fábio Pértille Thiago Bernardino Ricardo Zanella Carlos Guerrero-Bosagna Adroaldo José Zanella |
| author_facet | Patricia Tatemoto Fábio Pértille Thiago Bernardino Ricardo Zanella Carlos Guerrero-Bosagna Adroaldo José Zanella |
| author_sort | Patricia Tatemoto |
| collection | DOAJ |
| description | Epigenetic mechanisms are important modulators of neurodevelopmental outcomes in the offspring of animals challenged during pregnancy. Pregnant sows living in a confined environment are challenged with stress and lack of stimulation which may result in the expression of stereotypies (repetitive behaviours without an apparent function). Little attention has been devoted to the postnatal effects of maternal stereotypies in the offspring. We investigated how the environment and stereotypies of pregnant sows affected the neuro-epigenome of their piglets. We focused on the amygdala, frontal cortex, and hippocampus, brain regions related to emotionality, learning, memory, and stress response. Differentially methylated regions (DMRs) were investigated in these brain regions of male piglets born from sows kept in an enriched vs a barren environment. Within the latter group of piglets, we compared the brain methylomes of piglets born from sows expressing stereotypies vs sows not expressing stereotypies. DMRs emerged in each comparison. While the epigenome of the hippocampus and frontal cortex of piglets is mainly affected by the maternal environment, the epigenome of the amygdala is mainly affected by maternal stereotypies. The molecular pathways and mechanisms triggered in the brains of piglets by maternal environment or stereotypies are different, which is reflected on the differential gene function associated to the DMRs found in each piglets’ brain region . The present study is the first to investigate the neuro-epigenomic effects of maternal enrichment in pigs’ offspring and the first to investigate the neuro-epigenomic effects of maternal stereotypies in the offspring of a mammal. |
| first_indexed | 2024-03-11T23:05:06Z |
| format | Article |
| id | doaj.art-01e16d51a7d94fbbb59e056a70ec5047 |
| institution | Directory Open Access Journal |
| issn | 1559-2294 1559-2308 |
| language | English |
| last_indexed | 2024-03-11T23:05:06Z |
| publishDate | 2023-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Epigenetics |
| spelling | doaj.art-01e16d51a7d94fbbb59e056a70ec50472023-09-21T13:23:13ZengTaylor & Francis GroupEpigenetics1559-22941559-23082023-12-0118110.1080/15592294.2023.21966562196656An enriched maternal environment and stereotypies of sows differentially affect the neuro-epigenome of brain regions related to emotionality in their pigletsPatricia Tatemoto0Fábio Pértille1Thiago Bernardino2Ricardo Zanella3Carlos Guerrero-Bosagna4Adroaldo José Zanella5University of São PauloLinköping UniversityUniversity of São PauloUniversity of Passo FundoLinköping UniversityUniversity of São PauloEpigenetic mechanisms are important modulators of neurodevelopmental outcomes in the offspring of animals challenged during pregnancy. Pregnant sows living in a confined environment are challenged with stress and lack of stimulation which may result in the expression of stereotypies (repetitive behaviours without an apparent function). Little attention has been devoted to the postnatal effects of maternal stereotypies in the offspring. We investigated how the environment and stereotypies of pregnant sows affected the neuro-epigenome of their piglets. We focused on the amygdala, frontal cortex, and hippocampus, brain regions related to emotionality, learning, memory, and stress response. Differentially methylated regions (DMRs) were investigated in these brain regions of male piglets born from sows kept in an enriched vs a barren environment. Within the latter group of piglets, we compared the brain methylomes of piglets born from sows expressing stereotypies vs sows not expressing stereotypies. DMRs emerged in each comparison. While the epigenome of the hippocampus and frontal cortex of piglets is mainly affected by the maternal environment, the epigenome of the amygdala is mainly affected by maternal stereotypies. The molecular pathways and mechanisms triggered in the brains of piglets by maternal environment or stereotypies are different, which is reflected on the differential gene function associated to the DMRs found in each piglets’ brain region . The present study is the first to investigate the neuro-epigenomic effects of maternal enrichment in pigs’ offspring and the first to investigate the neuro-epigenomic effects of maternal stereotypies in the offspring of a mammal.http://dx.doi.org/10.1080/15592294.2023.2196656maternal environmentstereotypiesprenataloffspringbrainemotionalityepigeneticsdna methylation |
| spellingShingle | Patricia Tatemoto Fábio Pértille Thiago Bernardino Ricardo Zanella Carlos Guerrero-Bosagna Adroaldo José Zanella An enriched maternal environment and stereotypies of sows differentially affect the neuro-epigenome of brain regions related to emotionality in their piglets Epigenetics maternal environment stereotypies prenatal offspring brain emotionality epigenetics dna methylation |
| title | An enriched maternal environment and stereotypies of sows differentially affect the neuro-epigenome of brain regions related to emotionality in their piglets |
| title_full | An enriched maternal environment and stereotypies of sows differentially affect the neuro-epigenome of brain regions related to emotionality in their piglets |
| title_fullStr | An enriched maternal environment and stereotypies of sows differentially affect the neuro-epigenome of brain regions related to emotionality in their piglets |
| title_full_unstemmed | An enriched maternal environment and stereotypies of sows differentially affect the neuro-epigenome of brain regions related to emotionality in their piglets |
| title_short | An enriched maternal environment and stereotypies of sows differentially affect the neuro-epigenome of brain regions related to emotionality in their piglets |
| title_sort | enriched maternal environment and stereotypies of sows differentially affect the neuro epigenome of brain regions related to emotionality in their piglets |
| topic | maternal environment stereotypies prenatal offspring brain emotionality epigenetics dna methylation |
| url | http://dx.doi.org/10.1080/15592294.2023.2196656 |
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