Comparative Analysis of Seven Equations for Estimated Glomerular Filtration Rate and Their Impact on Chronic Kidney Disease Categorization in Korean Patients at Local Clinics and Hospitals
<b>(1) Background:</b> Accurate estimation of the glomerular filtration rate (eGFR) is essential for the early detection of chronic kidney disease (CKD), targeted interventions, and ongoing monitoring. Although various equations for calculating eGFR exist, comparative studies on eGFR lev...
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MDPI AG
2024-03-01
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| Series: | Journal of Clinical Medicine |
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| Online Access: | https://www.mdpi.com/2077-0383/13/7/1945 |
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| author | Rihwa Choi Sang Gon Lee Eun Hee Lee |
| author_facet | Rihwa Choi Sang Gon Lee Eun Hee Lee |
| author_sort | Rihwa Choi |
| collection | DOAJ |
| description | <b>(1) Background:</b> Accurate estimation of the glomerular filtration rate (eGFR) is essential for the early detection of chronic kidney disease (CKD), targeted interventions, and ongoing monitoring. Although various equations for calculating eGFR exist, comparative studies on eGFR levels and the impact of these equations on CKD prevalence are limited in the Korean population. <b>(2) Methods:</b> We compared eGFR levels calculated using seven equations and investigated the prevalence of CKD through a retrospective analysis of the data from Korean adult patients who visited local clinics and hospitals and underwent simultaneous serum creatinine (Cr) and cystatin C (Cys-C) measurements. The equations analyzed were: 2006 MDRD, 2009 CKD-EPI Cr, 2012 CKD-EPI Cys-C, 2012 CKD-EPI Cr & Cys-C, 2021 CKD-EPI Cr, 2021 CKD-EPI Cr & Cys-C, and 2021 EKFC. <b>(3) Results:</b> This study included 6688 Korean patients (3736 men and 2952 women; median age: 61.4; IQR: 47.2–73.4). Among the equations, the median eGFR levels were the highest when using the 2021 CKD-EPI Cr & Cys-C equation (85.1 mL/min/1.73 m<sup>2</sup>) and the lowest when using the 2006 MDRD equation (73.4 mL/min/1.73 m<sup>2</sup>). The highest prevalence of decreased eGFR < 60 mL/min/1.73 m<sup>2</sup> (equivalent to or worse than G3a CKD) was noted with the 2012 CKD-EPI Cys-C equation (32.4%), while the lowest was with the 2021 CKD-EPI Cr equation (22.9%), resulting in a maximum prevalence difference of 9.5%. <b>(4) Conclusions:</b> The prevalence of CKD varies based on the eGFR equation used and the patient’s age. Equations that include Cys-C may identify a larger number of patients with decreased kidney function. |
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| language | English |
| last_indexed | 2024-04-24T10:40:46Z |
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| series | Journal of Clinical Medicine |
| spelling | doaj.art-01e171279b9a40ae95f8d238e7d72e572024-04-12T13:21:06ZengMDPI AGJournal of Clinical Medicine2077-03832024-03-01137194510.3390/jcm13071945Comparative Analysis of Seven Equations for Estimated Glomerular Filtration Rate and Their Impact on Chronic Kidney Disease Categorization in Korean Patients at Local Clinics and HospitalsRihwa Choi0Sang Gon Lee1Eun Hee Lee2Department of Laboratory Medicine, Green Cross Laboratories, Yongin 16924, Republic of KoreaDepartment of Laboratory Medicine, Green Cross Laboratories, Yongin 16924, Republic of KoreaGreen Cross Laboratories, Yongin 16924, Republic of Korea<b>(1) Background:</b> Accurate estimation of the glomerular filtration rate (eGFR) is essential for the early detection of chronic kidney disease (CKD), targeted interventions, and ongoing monitoring. Although various equations for calculating eGFR exist, comparative studies on eGFR levels and the impact of these equations on CKD prevalence are limited in the Korean population. <b>(2) Methods:</b> We compared eGFR levels calculated using seven equations and investigated the prevalence of CKD through a retrospective analysis of the data from Korean adult patients who visited local clinics and hospitals and underwent simultaneous serum creatinine (Cr) and cystatin C (Cys-C) measurements. The equations analyzed were: 2006 MDRD, 2009 CKD-EPI Cr, 2012 CKD-EPI Cys-C, 2012 CKD-EPI Cr & Cys-C, 2021 CKD-EPI Cr, 2021 CKD-EPI Cr & Cys-C, and 2021 EKFC. <b>(3) Results:</b> This study included 6688 Korean patients (3736 men and 2952 women; median age: 61.4; IQR: 47.2–73.4). Among the equations, the median eGFR levels were the highest when using the 2021 CKD-EPI Cr & Cys-C equation (85.1 mL/min/1.73 m<sup>2</sup>) and the lowest when using the 2006 MDRD equation (73.4 mL/min/1.73 m<sup>2</sup>). The highest prevalence of decreased eGFR < 60 mL/min/1.73 m<sup>2</sup> (equivalent to or worse than G3a CKD) was noted with the 2012 CKD-EPI Cys-C equation (32.4%), while the lowest was with the 2021 CKD-EPI Cr equation (22.9%), resulting in a maximum prevalence difference of 9.5%. <b>(4) Conclusions:</b> The prevalence of CKD varies based on the eGFR equation used and the patient’s age. Equations that include Cys-C may identify a larger number of patients with decreased kidney function.https://www.mdpi.com/2077-0383/13/7/1945glomerular filtration ratechronic kidney diseasecystatin CequationKorea |
| spellingShingle | Rihwa Choi Sang Gon Lee Eun Hee Lee Comparative Analysis of Seven Equations for Estimated Glomerular Filtration Rate and Their Impact on Chronic Kidney Disease Categorization in Korean Patients at Local Clinics and Hospitals Journal of Clinical Medicine glomerular filtration rate chronic kidney disease cystatin C equation Korea |
| title | Comparative Analysis of Seven Equations for Estimated Glomerular Filtration Rate and Their Impact on Chronic Kidney Disease Categorization in Korean Patients at Local Clinics and Hospitals |
| title_full | Comparative Analysis of Seven Equations for Estimated Glomerular Filtration Rate and Their Impact on Chronic Kidney Disease Categorization in Korean Patients at Local Clinics and Hospitals |
| title_fullStr | Comparative Analysis of Seven Equations for Estimated Glomerular Filtration Rate and Their Impact on Chronic Kidney Disease Categorization in Korean Patients at Local Clinics and Hospitals |
| title_full_unstemmed | Comparative Analysis of Seven Equations for Estimated Glomerular Filtration Rate and Their Impact on Chronic Kidney Disease Categorization in Korean Patients at Local Clinics and Hospitals |
| title_short | Comparative Analysis of Seven Equations for Estimated Glomerular Filtration Rate and Their Impact on Chronic Kidney Disease Categorization in Korean Patients at Local Clinics and Hospitals |
| title_sort | comparative analysis of seven equations for estimated glomerular filtration rate and their impact on chronic kidney disease categorization in korean patients at local clinics and hospitals |
| topic | glomerular filtration rate chronic kidney disease cystatin C equation Korea |
| url | https://www.mdpi.com/2077-0383/13/7/1945 |
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