The role of N-methyladenosine modification in acute and chronic kidney diseases
Abstract N6-methyladenosine (m6A) modification is a kind of RNA modification in which methylation occurs at the sixth N position in adenosine in RNA, which can occur in various RNAs such as mRNAs, lncRNAs and miRNAs. This is one of the most prominent and frequent posttranscriptional modifications wi...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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BMC
2023-12-01
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| Series: | Molecular Medicine |
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| Online Access: | https://doi.org/10.1186/s10020-023-00764-w |
| _version_ | 1797397921217380352 |
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| author | Saiqi Qi Jie Song Linjun Chen Huachun Weng |
| author_facet | Saiqi Qi Jie Song Linjun Chen Huachun Weng |
| author_sort | Saiqi Qi |
| collection | DOAJ |
| description | Abstract N6-methyladenosine (m6A) modification is a kind of RNA modification in which methylation occurs at the sixth N position in adenosine in RNA, which can occur in various RNAs such as mRNAs, lncRNAs and miRNAs. This is one of the most prominent and frequent posttranscriptional modifications within organisms and has been shown to function dynamically and reversibly in a variety of ways, including splicing, export, attenuation and translation initiation efficiency to regulate RNA expression. There are three main enzymes associated with m6A modification: writers, readers and erasers. Increasing evidence has shown that m6A modification is associated with the onset and development of kidney disease. In this article, we address the important physiological and pathological roles of m6A modification in kidney diseases (uremia, ischemia–reperfusion kidney injury, drug-induced kidney injury, and diabetic nephropathy) and its molecular mechanisms to provide reference for the diagnosis and clinical management of kidney diseases. |
| first_indexed | 2024-03-09T01:17:12Z |
| format | Article |
| id | doaj.art-01e2297207054ad181004e9b82df9ee8 |
| institution | Directory Open Access Journal |
| issn | 1528-3658 |
| language | English |
| last_indexed | 2024-03-09T01:17:12Z |
| publishDate | 2023-12-01 |
| publisher | BMC |
| record_format | Article |
| series | Molecular Medicine |
| spelling | doaj.art-01e2297207054ad181004e9b82df9ee82023-12-10T12:22:23ZengBMCMolecular Medicine1528-36582023-12-0129111010.1186/s10020-023-00764-wThe role of N-methyladenosine modification in acute and chronic kidney diseasesSaiqi Qi0Jie Song1Linjun Chen2Huachun Weng3The College of Medical Technology, Shanghai University of Medicine & Health SciencesThe College of Medical Technology, Shanghai University of Medicine & Health SciencesThe College of Medical Technology, Shanghai University of Medicine & Health SciencesThe College of Medical Technology, Shanghai University of Medicine & Health SciencesAbstract N6-methyladenosine (m6A) modification is a kind of RNA modification in which methylation occurs at the sixth N position in adenosine in RNA, which can occur in various RNAs such as mRNAs, lncRNAs and miRNAs. This is one of the most prominent and frequent posttranscriptional modifications within organisms and has been shown to function dynamically and reversibly in a variety of ways, including splicing, export, attenuation and translation initiation efficiency to regulate RNA expression. There are three main enzymes associated with m6A modification: writers, readers and erasers. Increasing evidence has shown that m6A modification is associated with the onset and development of kidney disease. In this article, we address the important physiological and pathological roles of m6A modification in kidney diseases (uremia, ischemia–reperfusion kidney injury, drug-induced kidney injury, and diabetic nephropathy) and its molecular mechanisms to provide reference for the diagnosis and clinical management of kidney diseases.https://doi.org/10.1186/s10020-023-00764-wm6A modificationAcute kidney injuryChronic kidney disease |
| spellingShingle | Saiqi Qi Jie Song Linjun Chen Huachun Weng The role of N-methyladenosine modification in acute and chronic kidney diseases Molecular Medicine m6A modification Acute kidney injury Chronic kidney disease |
| title | The role of N-methyladenosine modification in acute and chronic kidney diseases |
| title_full | The role of N-methyladenosine modification in acute and chronic kidney diseases |
| title_fullStr | The role of N-methyladenosine modification in acute and chronic kidney diseases |
| title_full_unstemmed | The role of N-methyladenosine modification in acute and chronic kidney diseases |
| title_short | The role of N-methyladenosine modification in acute and chronic kidney diseases |
| title_sort | role of n methyladenosine modification in acute and chronic kidney diseases |
| topic | m6A modification Acute kidney injury Chronic kidney disease |
| url | https://doi.org/10.1186/s10020-023-00764-w |
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