Distinct Spatiotemporal Distribution of Bacterial Toxin-Produced Cellular cAMP Differentially Inhibits Opsonophagocytic Signaling

Distinct Spatiotemporal Distribution of Bacterial Toxin-Produced Cellular cAMP Differentially Inhibits Opsonophagocytic Signaling

Myeloid phagocytes have evolved to rapidly recognize invading pathogens and clear them through opsonophagocytic killing. The adenylate cyclase toxin (CyaA) of <i>Bordetella pertussis</i> and the edema toxin (ET) of <i>Bacillus anthracis</i> are both calmodulin-activated toxin...

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Bibliographic Details
Main Authors:	Shakir Hasan, Waheed Ur Rahman, Peter Sebo, Radim Osicka
Format:	Article
Language:	English
Published:	MDPI AG 2019-06-01
Series:	Toxins
Subjects:	3′,5′-cyclic adenosine monophosphate (cAMP) adenylate cyclase toxin edema toxin opsonophagocytosis phagocytes Syk Vav Pyk2 signaling pathway
Online Access:	https://www.mdpi.com/2072-6651/11/6/362

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