Leucine mediates cognitive dysfunction in early life stress-induced mental disorders by activating autophagy

Leucine mediates cognitive dysfunction in early life stress-induced mental disorders by activating autophagy

ObjectivesTo explore the relationship between leucine in cerebrospinal fluid (CSF) and cognitive dysfunction in rats with early life stress (ELS) induced mental illness, and pathophysiological mechanism involved.MethodsThe maternal separation (MS), an animal paradigm used widely as a preclinical mod...

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Bibliographic Details
Main Authors: Xiaotian Wang, Xue Wang, Fang Xie, Zhaowei Sun, Bomin Guo, Feng Li, Shida Wang, Ying Wang, Yingrui Tian, Yun Zhao, Lingjia Qian
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-01-01
Series:Frontiers in Cellular Neuroscience
Subjects:
maternal separation stress
cognitive impairment
leucine
cerebrospinal fluid
autophagy
mental disorders
Online Access:https://www.frontiersin.org/articles/10.3389/fncel.2022.1060712/full

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