Longitudinal analysis of built environment and aerosol contamination associated with isolated COVID-19 positive individuals
Abstract The indoor environment is the primary location for the transmission of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the causative agent of coronavirus disease 2019 (COVID-19), largely driven by respiratory particle accumulation in the air and increased connectivity between...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2022-05-01
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| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-022-11303-8 |
| _version_ | 1818250707021594624 |
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| author | Patrick F. Horve Leslie G. Dietz Garis Bowles Georgia MacCrone Andreas Olsen-Martinez Dale Northcutt Vincent Moore Liliana Barnatan Hooman Parhizkar Kevin G. Van Den Wymelenberg |
| author_facet | Patrick F. Horve Leslie G. Dietz Garis Bowles Georgia MacCrone Andreas Olsen-Martinez Dale Northcutt Vincent Moore Liliana Barnatan Hooman Parhizkar Kevin G. Van Den Wymelenberg |
| author_sort | Patrick F. Horve |
| collection | DOAJ |
| description | Abstract The indoor environment is the primary location for the transmission of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the causative agent of coronavirus disease 2019 (COVID-19), largely driven by respiratory particle accumulation in the air and increased connectivity between the individuals occupying indoor spaces. In this study, we aimed to track a cohort of subjects as they occupied a COVID-19 isolation dormitory to better understand the impact of subject and environmental viral load over time, symptoms, and room ventilation on the detectable viral load within a single room. We find that subject samples demonstrate a decrease in overall viral load over time, symptoms significantly impact environmental viral load, and we provide the first real-world evidence for decreased aerosol SARS-CoV-2 load with increasing ventilation, both from mechanical and window sources. These results may guide environmental viral surveillance strategies and be used to better control the spread of SARS-CoV-2 within built environments and better protect those caring for individuals with COVID-19. |
| first_indexed | 2024-12-12T15:56:40Z |
| format | Article |
| id | doaj.art-01e78f1a514943578e68c7b70c3ca471 |
| institution | Directory Open Access Journal |
| issn | 2045-2322 |
| language | English |
| last_indexed | 2024-12-12T15:56:40Z |
| publishDate | 2022-05-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj.art-01e78f1a514943578e68c7b70c3ca4712022-12-22T00:19:29ZengNature PortfolioScientific Reports2045-23222022-05-0112111310.1038/s41598-022-11303-8Longitudinal analysis of built environment and aerosol contamination associated with isolated COVID-19 positive individualsPatrick F. Horve0Leslie G. Dietz1Garis Bowles2Georgia MacCrone3Andreas Olsen-Martinez4Dale Northcutt5Vincent Moore6Liliana Barnatan7Hooman Parhizkar8Kevin G. Van Den Wymelenberg9Institute of Molecular Biology, University of OregonBiology and the Built Environment Center, University of OregonBiology and the Built Environment Center, University of OregonBiology and the Built Environment Center, University of OregonBiology and the Built Environment Center, University of OregonBiology and the Built Environment Center, University of OregonBiology and the Built Environment Center, University of OregonBiology and the Built Environment Center, University of OregonEnergy Studies in Buildings Laboratory, University of OregonBiology and the Built Environment Center, University of OregonAbstract The indoor environment is the primary location for the transmission of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the causative agent of coronavirus disease 2019 (COVID-19), largely driven by respiratory particle accumulation in the air and increased connectivity between the individuals occupying indoor spaces. In this study, we aimed to track a cohort of subjects as they occupied a COVID-19 isolation dormitory to better understand the impact of subject and environmental viral load over time, symptoms, and room ventilation on the detectable viral load within a single room. We find that subject samples demonstrate a decrease in overall viral load over time, symptoms significantly impact environmental viral load, and we provide the first real-world evidence for decreased aerosol SARS-CoV-2 load with increasing ventilation, both from mechanical and window sources. These results may guide environmental viral surveillance strategies and be used to better control the spread of SARS-CoV-2 within built environments and better protect those caring for individuals with COVID-19.https://doi.org/10.1038/s41598-022-11303-8 |
| spellingShingle | Patrick F. Horve Leslie G. Dietz Garis Bowles Georgia MacCrone Andreas Olsen-Martinez Dale Northcutt Vincent Moore Liliana Barnatan Hooman Parhizkar Kevin G. Van Den Wymelenberg Longitudinal analysis of built environment and aerosol contamination associated with isolated COVID-19 positive individuals Scientific Reports |
| title | Longitudinal analysis of built environment and aerosol contamination associated with isolated COVID-19 positive individuals |
| title_full | Longitudinal analysis of built environment and aerosol contamination associated with isolated COVID-19 positive individuals |
| title_fullStr | Longitudinal analysis of built environment and aerosol contamination associated with isolated COVID-19 positive individuals |
| title_full_unstemmed | Longitudinal analysis of built environment and aerosol contamination associated with isolated COVID-19 positive individuals |
| title_short | Longitudinal analysis of built environment and aerosol contamination associated with isolated COVID-19 positive individuals |
| title_sort | longitudinal analysis of built environment and aerosol contamination associated with isolated covid 19 positive individuals |
| url | https://doi.org/10.1038/s41598-022-11303-8 |
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