Identifying Intrinsically Disordered Protein Regions through a Deep Neural Network with Three Novel Sequence Features
The fast, reliable, and accurate identification of IDPRs is essential, as in recent years it has come to be recognized more and more that IDPRs have a wide impact on many important physiological processes, such as molecular recognition and molecular assembly, the regulation of transcription and tran...
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Format: | Article |
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MDPI AG
2022-02-01
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Series: | Life |
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Online Access: | https://www.mdpi.com/2075-1729/12/3/345 |
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author | Jiaxiang Zhao Zengke Wang |
author_facet | Jiaxiang Zhao Zengke Wang |
author_sort | Jiaxiang Zhao |
collection | DOAJ |
description | The fast, reliable, and accurate identification of IDPRs is essential, as in recent years it has come to be recognized more and more that IDPRs have a wide impact on many important physiological processes, such as molecular recognition and molecular assembly, the regulation of transcription and translation, protein phosphorylation, cellular signal transduction, etc. For the sake of cost-effectiveness, it is imperative to develop computational approaches for identifying IDPRs. In this study, a deep neural structure where a variant VGG19 is situated between two MLP networks is developed for identifying IDPRs. Furthermore, for the first time, three novel sequence features—i.e., persistent entropy and the probabilities associated with two and three consecutive amino acids of the protein sequence—are introduced for identifying IDPRs. The simulation results show that our neural structure either performs considerably better than other known methods or, when relying on a much smaller training set, attains a similar performance. Our deep neural structure, which exploits the VGG19 structure, is effective for identifying IDPRs. Furthermore, three novel sequence features—i.e., the persistent entropy and the probabilities associated with two and three consecutive amino acids of the protein sequence—could be used as valuable sequence features in the further development of identifying IDPRs. |
first_indexed | 2024-03-09T13:34:41Z |
format | Article |
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institution | Directory Open Access Journal |
issn | 2075-1729 |
language | English |
last_indexed | 2024-03-09T13:34:41Z |
publishDate | 2022-02-01 |
publisher | MDPI AG |
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series | Life |
spelling | doaj.art-01e8708c70ab4a5f91bd0753c54fbfc92023-11-30T21:13:24ZengMDPI AGLife2075-17292022-02-0112334510.3390/life12030345Identifying Intrinsically Disordered Protein Regions through a Deep Neural Network with Three Novel Sequence FeaturesJiaxiang Zhao0Zengke Wang1College of Electronic Information and Optical Engineering, Nankai University, Tianjin 300350, ChinaCollege of Electronic Information and Optical Engineering, Nankai University, Tianjin 300350, ChinaThe fast, reliable, and accurate identification of IDPRs is essential, as in recent years it has come to be recognized more and more that IDPRs have a wide impact on many important physiological processes, such as molecular recognition and molecular assembly, the regulation of transcription and translation, protein phosphorylation, cellular signal transduction, etc. For the sake of cost-effectiveness, it is imperative to develop computational approaches for identifying IDPRs. In this study, a deep neural structure where a variant VGG19 is situated between two MLP networks is developed for identifying IDPRs. Furthermore, for the first time, three novel sequence features—i.e., persistent entropy and the probabilities associated with two and three consecutive amino acids of the protein sequence—are introduced for identifying IDPRs. The simulation results show that our neural structure either performs considerably better than other known methods or, when relying on a much smaller training set, attains a similar performance. Our deep neural structure, which exploits the VGG19 structure, is effective for identifying IDPRs. Furthermore, three novel sequence features—i.e., the persistent entropy and the probabilities associated with two and three consecutive amino acids of the protein sequence—could be used as valuable sequence features in the further development of identifying IDPRs.https://www.mdpi.com/2075-1729/12/3/345intrinsically disordered proteinsthe persistent entropythe probabilities associated with two and three consecutive amino acidsVGG19 |
spellingShingle | Jiaxiang Zhao Zengke Wang Identifying Intrinsically Disordered Protein Regions through a Deep Neural Network with Three Novel Sequence Features Life intrinsically disordered proteins the persistent entropy the probabilities associated with two and three consecutive amino acids VGG19 |
title | Identifying Intrinsically Disordered Protein Regions through a Deep Neural Network with Three Novel Sequence Features |
title_full | Identifying Intrinsically Disordered Protein Regions through a Deep Neural Network with Three Novel Sequence Features |
title_fullStr | Identifying Intrinsically Disordered Protein Regions through a Deep Neural Network with Three Novel Sequence Features |
title_full_unstemmed | Identifying Intrinsically Disordered Protein Regions through a Deep Neural Network with Three Novel Sequence Features |
title_short | Identifying Intrinsically Disordered Protein Regions through a Deep Neural Network with Three Novel Sequence Features |
title_sort | identifying intrinsically disordered protein regions through a deep neural network with three novel sequence features |
topic | intrinsically disordered proteins the persistent entropy the probabilities associated with two and three consecutive amino acids VGG19 |
url | https://www.mdpi.com/2075-1729/12/3/345 |
work_keys_str_mv | AT jiaxiangzhao identifyingintrinsicallydisorderedproteinregionsthroughadeepneuralnetworkwiththreenovelsequencefeatures AT zengkewang identifyingintrinsicallydisorderedproteinregionsthroughadeepneuralnetworkwiththreenovelsequencefeatures |