The Protective Effects of Neoastilbin on Monosodium Urate Stimulated THP-1-Derived Macrophages and Gouty Arthritis in Mice through NF-κB and NLRP3 Inflammasome Pathways

The Protective Effects of Neoastilbin on Monosodium Urate Stimulated THP-1-Derived Macrophages and Gouty Arthritis in Mice through NF-κB and NLRP3 Inflammasome Pathways

Gouty arthritis (GA) is a frequent inflammatory disease characterized by pain, swelling, and stiffness of joints. Neoastilbin is a flavonoid isolated from the rhizome of <i>Smilax glabra</i>, which possesses various anti-inflammatory effects. However, the mechanism of neoastilbin in trea...

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Bibliographic Details
Main Authors: Wenjing Xu, Fenfen Li, Xiaoxi Zhang, Chenxi Wu, Yan Wang, Yanjing Yao, Daozong Xia
Format: Article
Language:English
Published: MDPI AG 2022-05-01
Series:Molecules
Subjects:
gouty arthritis
neoastilbin
NLRP3 inflammasome
NF-κB pathway
Online Access:https://www.mdpi.com/1420-3049/27/11/3477

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