Biscogniauxone, a New Isopyrrolonaphthoquinone Compound from the Fungus Biscogniauxia mediterranea Isolated from Deep-Sea Sediments
The properties and the production of new metabolites from the fungal strain LF657 isolated from the Herodotes Deep (2800 m depth) in the Mediterranean Sea are reported in this study. The new isolate was identified as Biscogniauxia mediterranea based on ITS1-5.8S-ITS2 and 28S rRNA gene sequences. A n...
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2016-11-01
|
| Series: | Marine Drugs |
| Subjects: | |
| Online Access: | http://www.mdpi.com/1660-3397/14/11/204 |
| _version_ | 1828370361015599104 |
|---|---|
| author | Bin Wu Jutta Wiese Rolf Schmaljohann Johannes F. Imhoff |
| author_facet | Bin Wu Jutta Wiese Rolf Schmaljohann Johannes F. Imhoff |
| author_sort | Bin Wu |
| collection | DOAJ |
| description | The properties and the production of new metabolites from the fungal strain LF657 isolated from the Herodotes Deep (2800 m depth) in the Mediterranean Sea are reported in this study. The new isolate was identified as Biscogniauxia mediterranea based on ITS1-5.8S-ITS2 and 28S rRNA gene sequences. A new isopyrrolonaphthoquinone with inhibitory activity against glycogen synthase kinase (GSK-3β) was isolated from this fungus. This is the first report of this class of compounds from a fungus isolated from a deep-sea sediment, as well as from a Biscogniauxia species. |
| first_indexed | 2024-04-14T06:37:56Z |
| format | Article |
| id | doaj.art-01eaa850eae54bfc80694492cbfb8a38 |
| institution | Directory Open Access Journal |
| issn | 1660-3397 |
| language | English |
| last_indexed | 2024-04-14T06:37:56Z |
| publishDate | 2016-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Marine Drugs |
| spelling | doaj.art-01eaa850eae54bfc80694492cbfb8a382022-12-22T02:07:25ZengMDPI AGMarine Drugs1660-33972016-11-01141120410.3390/md14110204md14110204Biscogniauxone, a New Isopyrrolonaphthoquinone Compound from the Fungus Biscogniauxia mediterranea Isolated from Deep-Sea SedimentsBin Wu0Jutta Wiese1Rolf Schmaljohann2Johannes F. Imhoff3GEOMAR Helmholtz Center for Ocean Research Kiel, RD3 Marine Microbiology, Düsternbrooker Weg 20, 24105 Kiel, GermanyGEOMAR Helmholtz Center for Ocean Research Kiel, RD3 Marine Microbiology, Düsternbrooker Weg 20, 24105 Kiel, GermanyGEOMAR Helmholtz Center for Ocean Research Kiel, RD3 Marine Microbiology, Düsternbrooker Weg 20, 24105 Kiel, GermanyGEOMAR Helmholtz Center for Ocean Research Kiel, RD3 Marine Microbiology, Düsternbrooker Weg 20, 24105 Kiel, GermanyThe properties and the production of new metabolites from the fungal strain LF657 isolated from the Herodotes Deep (2800 m depth) in the Mediterranean Sea are reported in this study. The new isolate was identified as Biscogniauxia mediterranea based on ITS1-5.8S-ITS2 and 28S rRNA gene sequences. A new isopyrrolonaphthoquinone with inhibitory activity against glycogen synthase kinase (GSK-3β) was isolated from this fungus. This is the first report of this class of compounds from a fungus isolated from a deep-sea sediment, as well as from a Biscogniauxia species.http://www.mdpi.com/1660-3397/14/11/204marine fungiglycogen synthase kinaseacetylcholinesteraseBiscogniauxia mediterraneadeep sea |
| spellingShingle | Bin Wu Jutta Wiese Rolf Schmaljohann Johannes F. Imhoff Biscogniauxone, a New Isopyrrolonaphthoquinone Compound from the Fungus Biscogniauxia mediterranea Isolated from Deep-Sea Sediments Marine Drugs marine fungi glycogen synthase kinase acetylcholinesterase Biscogniauxia mediterranea deep sea |
| title | Biscogniauxone, a New Isopyrrolonaphthoquinone Compound from the Fungus Biscogniauxia mediterranea Isolated from Deep-Sea Sediments |
| title_full | Biscogniauxone, a New Isopyrrolonaphthoquinone Compound from the Fungus Biscogniauxia mediterranea Isolated from Deep-Sea Sediments |
| title_fullStr | Biscogniauxone, a New Isopyrrolonaphthoquinone Compound from the Fungus Biscogniauxia mediterranea Isolated from Deep-Sea Sediments |
| title_full_unstemmed | Biscogniauxone, a New Isopyrrolonaphthoquinone Compound from the Fungus Biscogniauxia mediterranea Isolated from Deep-Sea Sediments |
| title_short | Biscogniauxone, a New Isopyrrolonaphthoquinone Compound from the Fungus Biscogniauxia mediterranea Isolated from Deep-Sea Sediments |
| title_sort | biscogniauxone a new isopyrrolonaphthoquinone compound from the fungus biscogniauxia mediterranea isolated from deep sea sediments |
| topic | marine fungi glycogen synthase kinase acetylcholinesterase Biscogniauxia mediterranea deep sea |
| url | http://www.mdpi.com/1660-3397/14/11/204 |
| work_keys_str_mv | AT binwu biscogniauxoneanewisopyrrolonaphthoquinonecompoundfromthefungusbiscogniauxiamediterraneaisolatedfromdeepseasediments AT juttawiese biscogniauxoneanewisopyrrolonaphthoquinonecompoundfromthefungusbiscogniauxiamediterraneaisolatedfromdeepseasediments AT rolfschmaljohann biscogniauxoneanewisopyrrolonaphthoquinonecompoundfromthefungusbiscogniauxiamediterraneaisolatedfromdeepseasediments AT johannesfimhoff biscogniauxoneanewisopyrrolonaphthoquinonecompoundfromthefungusbiscogniauxiamediterraneaisolatedfromdeepseasediments |