Vitamin D, vitamin D supplementation and atrial fibrillation risk in the general population: updated systematic review and meta-analysis of prospective studies
BackgroundSince the association of vitamin D with atrial fibrillation (AF) risk is still unclear, we conducted this updated meta-analysis of prospective studies to identify the relationship between vitamin D or vitamin D supplementation and AF in the general population.MethodsWe conducted a comprehe...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-09-01
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| Series: | Frontiers in Nutrition |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fnut.2023.1246359/full |
| _version_ | 1827808912802316288 |
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| author | Xiaoli Ding Jiying Lai Hehui Zhang Zongwen Guo |
| author_facet | Xiaoli Ding Jiying Lai Hehui Zhang Zongwen Guo |
| author_sort | Xiaoli Ding |
| collection | DOAJ |
| description | BackgroundSince the association of vitamin D with atrial fibrillation (AF) risk is still unclear, we conducted this updated meta-analysis of prospective studies to identify the relationship between vitamin D or vitamin D supplementation and AF in the general population.MethodsWe conducted a comprehensive search of multiple databases up to May 2023 for studies reporting vitamin D and AF. The hazard ratios (HRs) with 95% confidence intervals (CIs) were pooled by a random-effects model.ResultsA total of seven studies were included in this meta-analysis. Vitamin D deficiency (<20 ng/ml) was associated with increased AF incidence (HR: 1.12, 95% CI: 1.005–1.25). The HR was not significant with vitamin D insufficiency (20–30 ng/ml; HR: 1.09, 95% CI: 0.98–1.21). Each 10 ng/ml increase in serum vitamin D was associated with a significantly decreased AF incidence (HR: 0.95, 95% CI: 0.93–0.97). Two studies reported the effect of vitamin D supplements on AF incidence but reached inconsistent results.ConclusionsVitamin D deficiency or insufficiency was associated with an increased risk of AF in the general population. The role of vitamin D supplementation in AF prevention needs further investigation. |
| first_indexed | 2024-03-11T22:34:30Z |
| format | Article |
| id | doaj.art-01ebc506c7cf413abfd639dd47dac186 |
| institution | Directory Open Access Journal |
| issn | 2296-861X |
| language | English |
| last_indexed | 2024-03-11T22:34:30Z |
| publishDate | 2023-09-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Nutrition |
| spelling | doaj.art-01ebc506c7cf413abfd639dd47dac1862023-09-22T15:32:55ZengFrontiers Media S.A.Frontiers in Nutrition2296-861X2023-09-011010.3389/fnut.2023.12463591246359Vitamin D, vitamin D supplementation and atrial fibrillation risk in the general population: updated systematic review and meta-analysis of prospective studiesXiaoli Ding0Jiying Lai1Hehui Zhang2Zongwen Guo3Clinical Laboratory, The First Affiliated Hospital of Gannan Medical University, Ganzhou, Jiangxi, ChinaDepartment of Critical Care Medicine, The First Affiliated Hospital of Gannan Medical University, Ganzhou, Jiangxi, ChinaDepartment of Critical Care Medicine, The First Affiliated Hospital of Gannan Medical University, Ganzhou, Jiangxi, ChinaDepartment of Critical Care Medicine, The First Affiliated Hospital of Gannan Medical University, Ganzhou, Jiangxi, ChinaBackgroundSince the association of vitamin D with atrial fibrillation (AF) risk is still unclear, we conducted this updated meta-analysis of prospective studies to identify the relationship between vitamin D or vitamin D supplementation and AF in the general population.MethodsWe conducted a comprehensive search of multiple databases up to May 2023 for studies reporting vitamin D and AF. The hazard ratios (HRs) with 95% confidence intervals (CIs) were pooled by a random-effects model.ResultsA total of seven studies were included in this meta-analysis. Vitamin D deficiency (<20 ng/ml) was associated with increased AF incidence (HR: 1.12, 95% CI: 1.005–1.25). The HR was not significant with vitamin D insufficiency (20–30 ng/ml; HR: 1.09, 95% CI: 0.98–1.21). Each 10 ng/ml increase in serum vitamin D was associated with a significantly decreased AF incidence (HR: 0.95, 95% CI: 0.93–0.97). Two studies reported the effect of vitamin D supplements on AF incidence but reached inconsistent results.ConclusionsVitamin D deficiency or insufficiency was associated with an increased risk of AF in the general population. The role of vitamin D supplementation in AF prevention needs further investigation.https://www.frontiersin.org/articles/10.3389/fnut.2023.1246359/fullatrial fibrillationvitamin Drelationshipsupplementationmeta |
| spellingShingle | Xiaoli Ding Jiying Lai Hehui Zhang Zongwen Guo Vitamin D, vitamin D supplementation and atrial fibrillation risk in the general population: updated systematic review and meta-analysis of prospective studies Frontiers in Nutrition atrial fibrillation vitamin D relationship supplementation meta |
| title | Vitamin D, vitamin D supplementation and atrial fibrillation risk in the general population: updated systematic review and meta-analysis of prospective studies |
| title_full | Vitamin D, vitamin D supplementation and atrial fibrillation risk in the general population: updated systematic review and meta-analysis of prospective studies |
| title_fullStr | Vitamin D, vitamin D supplementation and atrial fibrillation risk in the general population: updated systematic review and meta-analysis of prospective studies |
| title_full_unstemmed | Vitamin D, vitamin D supplementation and atrial fibrillation risk in the general population: updated systematic review and meta-analysis of prospective studies |
| title_short | Vitamin D, vitamin D supplementation and atrial fibrillation risk in the general population: updated systematic review and meta-analysis of prospective studies |
| title_sort | vitamin d vitamin d supplementation and atrial fibrillation risk in the general population updated systematic review and meta analysis of prospective studies |
| topic | atrial fibrillation vitamin D relationship supplementation meta |
| url | https://www.frontiersin.org/articles/10.3389/fnut.2023.1246359/full |
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