Dieckol, an Algae-Derived Phenolic Compound, Suppresses UVB-Induced Skin Damage in Human Dermal Fibroblasts and Its Underlying Mechanisms
Ultraviolet (UV) irradiation is considered to be the primary environmental factor that causes skin damage. In the present study, we investigated the protective effect of dieckol (DK), a compound isolated from the brown seaweed <i>Ecklonia cava</i>, against UVB-induced skin damage in huma...
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MDPI AG
2021-02-01
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| Series: | Antioxidants |
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| Online Access: | https://www.mdpi.com/2076-3921/10/3/352 |
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| author | Lei Wang Jun-Geon Je Hye-Won Yang You-Jin Jeon Seungheon Lee |
| author_facet | Lei Wang Jun-Geon Je Hye-Won Yang You-Jin Jeon Seungheon Lee |
| author_sort | Lei Wang |
| collection | DOAJ |
| description | Ultraviolet (UV) irradiation is considered to be the primary environmental factor that causes skin damage. In the present study, we investigated the protective effect of dieckol (DK), a compound isolated from the brown seaweed <i>Ecklonia cava</i>, against UVB-induced skin damage in human dermal fibroblasts (HDF cells). The results indicated that DK effectively inhibited the activity of collagenase. DK remarkably reduced the intracellular reactive oxygen species level and improved the viability of UVB-irradiated HDF cells. Besides, DK significantly and dose-dependently improved collagen synthesis and inhibited intracellular collagenase activity in UVB-irradiated HDF cells. In addition, DK markedly reduced the expression of proinflammatory cytokines and matrix metalloproteinases. Further analyses revealed that these processes were mediated through the regulation of nuclear factor kappa B, activator protein 1, and mitogen-activated protein kinase signaling pathways in the UVB-irradiated HDF cells. In conclusion, these results indicate that DK possesses strong in vitro photoprotective effects and therefore has the potential to be used as an ingredient in the cosmeceutical industry. |
| first_indexed | 2024-03-09T00:28:59Z |
| format | Article |
| id | doaj.art-01ebead45d8c40fc96f327affc7178b4 |
| institution | Directory Open Access Journal |
| issn | 2076-3921 |
| language | English |
| last_indexed | 2024-03-09T00:28:59Z |
| publishDate | 2021-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Antioxidants |
| spelling | doaj.art-01ebead45d8c40fc96f327affc7178b42023-12-11T18:35:40ZengMDPI AGAntioxidants2076-39212021-02-0110335210.3390/antiox10030352Dieckol, an Algae-Derived Phenolic Compound, Suppresses UVB-Induced Skin Damage in Human Dermal Fibroblasts and Its Underlying MechanismsLei Wang0Jun-Geon Je1Hye-Won Yang2You-Jin Jeon3Seungheon Lee4College of Food Science and Engineering, Ocean University of China, Qingdao 266003, ChinaDepartment of Marine Life Sciences, Jeju National University, Jeju 63243, KoreaDepartment of Marine Life Sciences, Jeju National University, Jeju 63243, KoreaDepartment of Marine Life Sciences, Jeju National University, Jeju 63243, KoreaDepartment of Marine Life Sciences, Jeju National University, Jeju 63243, KoreaUltraviolet (UV) irradiation is considered to be the primary environmental factor that causes skin damage. In the present study, we investigated the protective effect of dieckol (DK), a compound isolated from the brown seaweed <i>Ecklonia cava</i>, against UVB-induced skin damage in human dermal fibroblasts (HDF cells). The results indicated that DK effectively inhibited the activity of collagenase. DK remarkably reduced the intracellular reactive oxygen species level and improved the viability of UVB-irradiated HDF cells. Besides, DK significantly and dose-dependently improved collagen synthesis and inhibited intracellular collagenase activity in UVB-irradiated HDF cells. In addition, DK markedly reduced the expression of proinflammatory cytokines and matrix metalloproteinases. Further analyses revealed that these processes were mediated through the regulation of nuclear factor kappa B, activator protein 1, and mitogen-activated protein kinase signaling pathways in the UVB-irradiated HDF cells. In conclusion, these results indicate that DK possesses strong in vitro photoprotective effects and therefore has the potential to be used as an ingredient in the cosmeceutical industry.https://www.mdpi.com/2076-3921/10/3/352UVB irradiationDieckolphotoagingmatrix metalloproteinasespro-inflammatory cytokines |
| spellingShingle | Lei Wang Jun-Geon Je Hye-Won Yang You-Jin Jeon Seungheon Lee Dieckol, an Algae-Derived Phenolic Compound, Suppresses UVB-Induced Skin Damage in Human Dermal Fibroblasts and Its Underlying Mechanisms Antioxidants UVB irradiation Dieckol photoaging matrix metalloproteinases pro-inflammatory cytokines |
| title | Dieckol, an Algae-Derived Phenolic Compound, Suppresses UVB-Induced Skin Damage in Human Dermal Fibroblasts and Its Underlying Mechanisms |
| title_full | Dieckol, an Algae-Derived Phenolic Compound, Suppresses UVB-Induced Skin Damage in Human Dermal Fibroblasts and Its Underlying Mechanisms |
| title_fullStr | Dieckol, an Algae-Derived Phenolic Compound, Suppresses UVB-Induced Skin Damage in Human Dermal Fibroblasts and Its Underlying Mechanisms |
| title_full_unstemmed | Dieckol, an Algae-Derived Phenolic Compound, Suppresses UVB-Induced Skin Damage in Human Dermal Fibroblasts and Its Underlying Mechanisms |
| title_short | Dieckol, an Algae-Derived Phenolic Compound, Suppresses UVB-Induced Skin Damage in Human Dermal Fibroblasts and Its Underlying Mechanisms |
| title_sort | dieckol an algae derived phenolic compound suppresses uvb induced skin damage in human dermal fibroblasts and its underlying mechanisms |
| topic | UVB irradiation Dieckol photoaging matrix metalloproteinases pro-inflammatory cytokines |
| url | https://www.mdpi.com/2076-3921/10/3/352 |
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