Identification of metabolic biomarkers of chronic vagus nerve stimulation (VNS) in subjects with drug‐resistant epilepsy (DRE)

Identification of metabolic biomarkers of chronic vagus nerve stimulation (VNS) in subjects with drug‐resistant epilepsy (DRE)

Abstract Neuromodulation by means of vagus nerve stimulation (VNS) therapy, reduces seizure frequency and improves quality of life in subjects with drug‐resistant epilepsy (DRE), yet its molecular mechanism remains unclear. This study investigates the impact of chronic VNS on lipid bioactive metabol...

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Bibliographic Details
Main Authors: Claudia Manca, Roberta Coa, Elisabetta Murru, Gianfranca Carta, Giovanni Pinna, Roberto Sanfilippo, Lorenzo Polizzi, Marco Pistis, Paolo Follesa, Monica Puligheddu, Sebastiano Banni
Format: Article
Language:English
Published: Wiley 2024-02-01
Series:Epilepsia Open
Subjects:
bioactive molecules
energy and lipid metabolism
fatty acids
neuromodulation
PPARα
SIRT1
Online Access:https://doi.org/10.1002/epi4.12871

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