MODELING AND ANALYSIS OF MOLECULAR DYNAMICS OF SILICON-SOLVENT-VINPOCETIN SYSTEMS AND SILICON-SOLVENT-VINPOCETIN DIOXIDE
The process of desorption of vinpocetine on the surface of crystalline silicon and silicon oxide in various media has been studied by molecular dynamics modeling. The desorption of vinpocetine in water has been established both from the surface of silicon and from the surface of silicon oxide. The c...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | Russian |
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LLC Center of Pharmaceutical Analytics (LLC «CPHA»)
2019-01-01
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| Series: | Разработка и регистрация лекарственных средств |
| Subjects: | |
| Online Access: | https://www.pharmjournal.ru/jour/article/view/495 |
| _version_ | 1797875002180108288 |
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| author | Yu. A. Polkovnikova A. S. Lenshin A. A. Glushko O. M. Khishova |
| author_facet | Yu. A. Polkovnikova A. S. Lenshin A. A. Glushko O. M. Khishova |
| author_sort | Yu. A. Polkovnikova |
| collection | DOAJ |
| description | The process of desorption of vinpocetine on the surface of crystalline silicon and silicon oxide in various media has been studied by molecular dynamics modeling. The desorption of vinpocetine in water has been established both from the surface of silicon and from the surface of silicon oxide. The character of the desorption of vinpocetine from silicon and silicon oxide at pH 6.8 and pH 7 differs insignificantly (within the error of the simulation results). The desorption of vinpocetine in acidic medium (pH 2) from silicon and silicon oxide occurs more efficiently and at a higher rate, compared to pH 6.8 and pH 7. |
| first_indexed | 2024-04-10T01:40:52Z |
| format | Article |
| id | doaj.art-01ef5a27683341abacb827a1754b80cc |
| institution | Directory Open Access Journal |
| issn | 2305-2066 2658-5049 |
| language | Russian |
| last_indexed | 2024-04-10T01:40:52Z |
| publishDate | 2019-01-01 |
| publisher | LLC Center of Pharmaceutical Analytics (LLC «CPHA») |
| record_format | Article |
| series | Разработка и регистрация лекарственных средств |
| spelling | doaj.art-01ef5a27683341abacb827a1754b80cc2023-03-13T09:13:58ZrusLLC Center of Pharmaceutical Analytics (LLC «CPHA»)Разработка и регистрация лекарственных средств2305-20662658-50492019-01-01044449495MODELING AND ANALYSIS OF MOLECULAR DYNAMICS OF SILICON-SOLVENT-VINPOCETIN SYSTEMS AND SILICON-SOLVENT-VINPOCETIN DIOXIDEYu. A. Polkovnikova0A. S. Lenshin1A. A. Glushko2O. M. Khishova3ФГБОУ ВО «Воронежский государственный университет»ФГБОУ ВО «Воронежский государственный университет»Пятигорский медико-фармацевтический институт - филиал ФГБОУ ВО ВолгГМУ Минздрава РоссииУО «Витебский государственный медицинский университет»The process of desorption of vinpocetine on the surface of crystalline silicon and silicon oxide in various media has been studied by molecular dynamics modeling. The desorption of vinpocetine in water has been established both from the surface of silicon and from the surface of silicon oxide. The character of the desorption of vinpocetine from silicon and silicon oxide at pH 6.8 and pH 7 differs insignificantly (within the error of the simulation results). The desorption of vinpocetine in acidic medium (pH 2) from silicon and silicon oxide occurs more efficiently and at a higher rate, compared to pH 6.8 and pH 7.https://www.pharmjournal.ru/jour/article/view/495молекулярная динамикавинпоцетинадсорбциякремнийоксид кремния |
| spellingShingle | Yu. A. Polkovnikova A. S. Lenshin A. A. Glushko O. M. Khishova MODELING AND ANALYSIS OF MOLECULAR DYNAMICS OF SILICON-SOLVENT-VINPOCETIN SYSTEMS AND SILICON-SOLVENT-VINPOCETIN DIOXIDE Разработка и регистрация лекарственных средств молекулярная динамика винпоцетин адсорбция кремний оксид кремния |
| title | MODELING AND ANALYSIS OF MOLECULAR DYNAMICS OF SILICON-SOLVENT-VINPOCETIN SYSTEMS AND SILICON-SOLVENT-VINPOCETIN DIOXIDE |
| title_full | MODELING AND ANALYSIS OF MOLECULAR DYNAMICS OF SILICON-SOLVENT-VINPOCETIN SYSTEMS AND SILICON-SOLVENT-VINPOCETIN DIOXIDE |
| title_fullStr | MODELING AND ANALYSIS OF MOLECULAR DYNAMICS OF SILICON-SOLVENT-VINPOCETIN SYSTEMS AND SILICON-SOLVENT-VINPOCETIN DIOXIDE |
| title_full_unstemmed | MODELING AND ANALYSIS OF MOLECULAR DYNAMICS OF SILICON-SOLVENT-VINPOCETIN SYSTEMS AND SILICON-SOLVENT-VINPOCETIN DIOXIDE |
| title_short | MODELING AND ANALYSIS OF MOLECULAR DYNAMICS OF SILICON-SOLVENT-VINPOCETIN SYSTEMS AND SILICON-SOLVENT-VINPOCETIN DIOXIDE |
| title_sort | modeling and analysis of molecular dynamics of silicon solvent vinpocetin systems and silicon solvent vinpocetin dioxide |
| topic | молекулярная динамика винпоцетин адсорбция кремний оксид кремния |
| url | https://www.pharmjournal.ru/jour/article/view/495 |
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