Disrupted Alpha-Ketoglutarate Homeostasis: Understanding Kidney Diseases from the View of Metabolism and Beyond
Lijing Guo,1,2,* Shihua Chen,1,2,* Liping Ou,1,2,* Shangmei Li,1 Zhen-Nan Ye,1,2 Hua-Feng Liu1,2 1Guangdong Provincial Key Laboratory of Autophagy and Major Chronic Non-Communicable Diseases, Affiliated Hospital of Guangdong Medical University, Zhanjiang, 524001, People’s Rep...
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| Format: | Article |
| Language: | English |
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Dove Medical Press
2022-06-01
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| Series: | Diabetes, Metabolic Syndrome and Obesity |
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| Online Access: | https://www.dovepress.com/disrupted-alpha-ketoglutarate-homeostasis-understanding-kidney-disease-peer-reviewed-fulltext-article-DMSO |
| _version_ | 1797713119108136960 |
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| author | Guo L Chen S Ou L Li S Ye ZN Liu HF |
| author_facet | Guo L Chen S Ou L Li S Ye ZN Liu HF |
| author_sort | Guo L |
| collection | DOAJ |
| description | Lijing Guo,1,2,* Shihua Chen,1,2,* Liping Ou,1,2,* Shangmei Li,1 Zhen-Nan Ye,1,2 Hua-Feng Liu1,2 1Guangdong Provincial Key Laboratory of Autophagy and Major Chronic Non-Communicable Diseases, Affiliated Hospital of Guangdong Medical University, Zhanjiang, 524001, People’s Republic of China; 2Institute of Nephrology, Affiliated Hospital of Guangdong Medical University, Zhanjiang, 524001, People’s Republic of China*These authors contributed equally to this workCorrespondence: Zhen-Nan Ye; Hua-Feng Liu, Email yezhennan12@mails.ucas.ac.cn; hf-liu@263.netAbstract: Alpha-ketoglutarate (AKG) is a key intermediate of various metabolic pathways including tricarboxylic acid (TCA) cycle, anabolic and catabolic reactions of amino acids, and collagen biosynthesis. Meanwhile, AKG also participates in multiple signaling pathways related to cellular redox regulation, epigenetic processes, and inflammation response. Emerging evidence has shown that kidney diseases like diabetic nephropathy and renal ischemia/reperfusion injury are associated with metabolic disorders. In consistence with metabolic role of AKG, further metabolomics study demonstrated a dysregulated AKG level in kidney diseases. Intriguingly, earlier studies during the years of 1980s and 1990s indicated that AKG may benefit wound healing and surgery recovery. Recently, interests on AKG are arising again due to its protective roles on healthy ageing, which may shed light on developing novel therapeutic strategies against age-related diseases including renal diseases. This review will summarize the physiological and pathological properties of AKG, as well as the underlying molecular mechanisms, with a special emphasis on kidney diseases.Keywords: alpha-ketoglutarate, kidney diseases, metabolism, diabetic nephropathy, acute kidney injury |
| first_indexed | 2024-03-12T07:31:46Z |
| format | Article |
| id | doaj.art-01ef7e25a1b54af7941301eefd37fd9a |
| institution | Directory Open Access Journal |
| issn | 1178-7007 |
| language | English |
| last_indexed | 2024-03-12T07:31:46Z |
| publishDate | 2022-06-01 |
| publisher | Dove Medical Press |
| record_format | Article |
| series | Diabetes, Metabolic Syndrome and Obesity |
| spelling | doaj.art-01ef7e25a1b54af7941301eefd37fd9a2023-09-02T21:44:23ZengDove Medical PressDiabetes, Metabolic Syndrome and Obesity1178-70072022-06-01Volume 151961197476196Disrupted Alpha-Ketoglutarate Homeostasis: Understanding Kidney Diseases from the View of Metabolism and BeyondGuo LChen SOu LLi SYe ZNLiu HFLijing Guo,1,2,* Shihua Chen,1,2,* Liping Ou,1,2,* Shangmei Li,1 Zhen-Nan Ye,1,2 Hua-Feng Liu1,2 1Guangdong Provincial Key Laboratory of Autophagy and Major Chronic Non-Communicable Diseases, Affiliated Hospital of Guangdong Medical University, Zhanjiang, 524001, People’s Republic of China; 2Institute of Nephrology, Affiliated Hospital of Guangdong Medical University, Zhanjiang, 524001, People’s Republic of China*These authors contributed equally to this workCorrespondence: Zhen-Nan Ye; Hua-Feng Liu, Email yezhennan12@mails.ucas.ac.cn; hf-liu@263.netAbstract: Alpha-ketoglutarate (AKG) is a key intermediate of various metabolic pathways including tricarboxylic acid (TCA) cycle, anabolic and catabolic reactions of amino acids, and collagen biosynthesis. Meanwhile, AKG also participates in multiple signaling pathways related to cellular redox regulation, epigenetic processes, and inflammation response. Emerging evidence has shown that kidney diseases like diabetic nephropathy and renal ischemia/reperfusion injury are associated with metabolic disorders. In consistence with metabolic role of AKG, further metabolomics study demonstrated a dysregulated AKG level in kidney diseases. Intriguingly, earlier studies during the years of 1980s and 1990s indicated that AKG may benefit wound healing and surgery recovery. Recently, interests on AKG are arising again due to its protective roles on healthy ageing, which may shed light on developing novel therapeutic strategies against age-related diseases including renal diseases. This review will summarize the physiological and pathological properties of AKG, as well as the underlying molecular mechanisms, with a special emphasis on kidney diseases.Keywords: alpha-ketoglutarate, kidney diseases, metabolism, diabetic nephropathy, acute kidney injuryhttps://www.dovepress.com/disrupted-alpha-ketoglutarate-homeostasis-understanding-kidney-disease-peer-reviewed-fulltext-article-DMSOalpha-ketoglutaratekidney diseasesmetabolismdiabetic nephropathyacute kidney injury |
| spellingShingle | Guo L Chen S Ou L Li S Ye ZN Liu HF Disrupted Alpha-Ketoglutarate Homeostasis: Understanding Kidney Diseases from the View of Metabolism and Beyond Diabetes, Metabolic Syndrome and Obesity alpha-ketoglutarate kidney diseases metabolism diabetic nephropathy acute kidney injury |
| title | Disrupted Alpha-Ketoglutarate Homeostasis: Understanding Kidney Diseases from the View of Metabolism and Beyond |
| title_full | Disrupted Alpha-Ketoglutarate Homeostasis: Understanding Kidney Diseases from the View of Metabolism and Beyond |
| title_fullStr | Disrupted Alpha-Ketoglutarate Homeostasis: Understanding Kidney Diseases from the View of Metabolism and Beyond |
| title_full_unstemmed | Disrupted Alpha-Ketoglutarate Homeostasis: Understanding Kidney Diseases from the View of Metabolism and Beyond |
| title_short | Disrupted Alpha-Ketoglutarate Homeostasis: Understanding Kidney Diseases from the View of Metabolism and Beyond |
| title_sort | disrupted alpha ketoglutarate homeostasis understanding kidney diseases from the view of metabolism and beyond |
| topic | alpha-ketoglutarate kidney diseases metabolism diabetic nephropathy acute kidney injury |
| url | https://www.dovepress.com/disrupted-alpha-ketoglutarate-homeostasis-understanding-kidney-disease-peer-reviewed-fulltext-article-DMSO |
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