The role of lipotoxicity in kidney disease: From molecular mechanisms to therapeutic prospects
Lipotoxicity is the dysregulation of the lipid environment and/or intracellular composition that leads to accumulation of harmful lipids and ultimately to organelle dysfunction, abnormal activation of intracellular signaling pathways, chronic inflammation and cell death. It plays an important role i...
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| Format: | Article |
| Language: | English |
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Elsevier
2023-05-01
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| Series: | Biomedicine & Pharmacotherapy |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S0753332223002536 |
| _version_ | 1797857659365359616 |
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| author | Linan Ren Haiying Cui Yao Wang Feng Ju Yunjia Cai Xiaokun Gang Guixia Wang |
| author_facet | Linan Ren Haiying Cui Yao Wang Feng Ju Yunjia Cai Xiaokun Gang Guixia Wang |
| author_sort | Linan Ren |
| collection | DOAJ |
| description | Lipotoxicity is the dysregulation of the lipid environment and/or intracellular composition that leads to accumulation of harmful lipids and ultimately to organelle dysfunction, abnormal activation of intracellular signaling pathways, chronic inflammation and cell death. It plays an important role in the development of acute kidney injury and chronic kidney disease, including diabetic nephropathy, obesity-related glomerulopathy, age-related kidney disease, polycystic kidney disease, and the like. However, the mechanisms of lipid overload and kidney injury remain poorly understood. Herein, we discuss two pivotal aspects of lipotoxic kidney injury. First, we analyzed the mechanism of lipid accumulation in the kidney. Accumulating data indicate that the mechanisms of lipid overload in different kidney diseases are inconsistent. Second, we summarize the multiple mechanisms by which lipotoxic species affect the kidney cell behavior, including oxidative stress, endoplasmic reticulum stress, mitochondrial dysfunction, dysregulated autophagy, and inflammation, highlighting the central role of oxidative stress. Blocking the molecular pathways of lipid accumulation in the kidney and the damage of the kidney by lipid overload may be potential therapeutic targets for kidney disease, and antioxidant drugs may play a pivotal role in the treatment of kidney disease in the future. |
| first_indexed | 2024-04-09T21:01:27Z |
| format | Article |
| id | doaj.art-01efa92b84754b339ba8d421c160274d |
| institution | Directory Open Access Journal |
| issn | 0753-3322 |
| language | English |
| last_indexed | 2024-04-09T21:01:27Z |
| publishDate | 2023-05-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Biomedicine & Pharmacotherapy |
| spelling | doaj.art-01efa92b84754b339ba8d421c160274d2023-03-29T09:22:28ZengElsevierBiomedicine & Pharmacotherapy0753-33222023-05-01161114465The role of lipotoxicity in kidney disease: From molecular mechanisms to therapeutic prospectsLinan Ren0Haiying Cui1Yao Wang2Feng Ju3Yunjia Cai4Xiaokun Gang5Guixia Wang6Department of Endocrinology and Metabolism, First Hospital of Jilin University, Changchun 130021, Jilin, China; Institute of Translational Medicine, First Hospital of Jilin University, Changchun 130021, Jilin, ChinaDepartment of Endocrinology and Metabolism, First Hospital of Jilin University, Changchun 130021, Jilin, China; Institute of Translational Medicine, First Hospital of Jilin University, Changchun 130021, Jilin, ChinaDepartment of Orthopedics, The Second Hospital of Jilin University, Changchun 130021, Jilin, ChinaDepartment of Orthopedics, Yuci District People’s Hospital, Yuci 030600, Shanxi, ChinaDepartment of Endocrinology and Metabolism, First Hospital of Jilin University, Changchun 130021, Jilin, ChinaDepartment of Endocrinology and Metabolism, First Hospital of Jilin University, Changchun 130021, Jilin, China; Corresponding authors.Department of Endocrinology and Metabolism, First Hospital of Jilin University, Changchun 130021, Jilin, China; Corresponding authors.Lipotoxicity is the dysregulation of the lipid environment and/or intracellular composition that leads to accumulation of harmful lipids and ultimately to organelle dysfunction, abnormal activation of intracellular signaling pathways, chronic inflammation and cell death. It plays an important role in the development of acute kidney injury and chronic kidney disease, including diabetic nephropathy, obesity-related glomerulopathy, age-related kidney disease, polycystic kidney disease, and the like. However, the mechanisms of lipid overload and kidney injury remain poorly understood. Herein, we discuss two pivotal aspects of lipotoxic kidney injury. First, we analyzed the mechanism of lipid accumulation in the kidney. Accumulating data indicate that the mechanisms of lipid overload in different kidney diseases are inconsistent. Second, we summarize the multiple mechanisms by which lipotoxic species affect the kidney cell behavior, including oxidative stress, endoplasmic reticulum stress, mitochondrial dysfunction, dysregulated autophagy, and inflammation, highlighting the central role of oxidative stress. Blocking the molecular pathways of lipid accumulation in the kidney and the damage of the kidney by lipid overload may be potential therapeutic targets for kidney disease, and antioxidant drugs may play a pivotal role in the treatment of kidney disease in the future.http://www.sciencedirect.com/science/article/pii/S0753332223002536LipotoxicityLipid overloadAcute kidney injuryChronic kidney diseaseMolecular mechanism |
| spellingShingle | Linan Ren Haiying Cui Yao Wang Feng Ju Yunjia Cai Xiaokun Gang Guixia Wang The role of lipotoxicity in kidney disease: From molecular mechanisms to therapeutic prospects Biomedicine & Pharmacotherapy Lipotoxicity Lipid overload Acute kidney injury Chronic kidney disease Molecular mechanism |
| title | The role of lipotoxicity in kidney disease: From molecular mechanisms to therapeutic prospects |
| title_full | The role of lipotoxicity in kidney disease: From molecular mechanisms to therapeutic prospects |
| title_fullStr | The role of lipotoxicity in kidney disease: From molecular mechanisms to therapeutic prospects |
| title_full_unstemmed | The role of lipotoxicity in kidney disease: From molecular mechanisms to therapeutic prospects |
| title_short | The role of lipotoxicity in kidney disease: From molecular mechanisms to therapeutic prospects |
| title_sort | role of lipotoxicity in kidney disease from molecular mechanisms to therapeutic prospects |
| topic | Lipotoxicity Lipid overload Acute kidney injury Chronic kidney disease Molecular mechanism |
| url | http://www.sciencedirect.com/science/article/pii/S0753332223002536 |
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