BONE METABOLISM AND ITS REGULATION IN PATIENTS WITH ANKYLOSING SPONDYLITIS
Osteoporosis in ankylosing spondylitis (AS) may exacerbate pain and functional disorders and increases the risk of fractures. The mechanisms of its development in AS have not been adequately studied.Objective: to study bone mineral density (BMD) and its regulation in patients with AS.Subjects and...
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| Format: | Article |
| Language: | Russian |
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IMA PRESS LLC
2016-12-01
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| Series: | Научно-практическая ревматология |
| Subjects: | |
| Online Access: | https://rsp.mediar-press.net/rsp/article/view/2294 |
| _version_ | 1797862689685372928 |
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| author | O. V. Bugrova K. A. Nagornova N. E. Artemova |
| author_facet | O. V. Bugrova K. A. Nagornova N. E. Artemova |
| author_sort | O. V. Bugrova |
| collection | DOAJ |
| description | Osteoporosis in ankylosing spondylitis (AS) may exacerbate pain and functional disorders and increases the risk of fractures. The mechanisms of its development in AS have not been adequately studied.Objective: to study bone mineral density (BMD) and its regulation in patients with AS.Subjects and methods. 70 patients (mean age, 43.2±9.2 years) with a documented diagnosis of AS (mean disease duration, 17.1±7.8 years) and a control group of 30 healthy individuals were examined. All the patients underwent estimation of BMD and the serum concentrations of osteocalcin, CrossLaps, and key regulators of osteoclastogenesis, such as osteoprotegerin (OPG) and a receptor activator of nuclear factor kappa-B ligand (RANKL) by an enzyme immunoassay. Results and discussion. In patients with AS, bone metabolism was characterized by a decrease in bone formation and by some increase in bone tissue degradation especially in high AS activity. These patients showed the elevated levels of the major blocker of osteoclastogenesis OPG and the OPG/RANKL ratio, which can cause the process of ossification characteristic of AS. |
| first_indexed | 2024-04-09T22:23:35Z |
| format | Article |
| id | doaj.art-01f05f44882947169788408dc8a8fa5c |
| institution | Directory Open Access Journal |
| issn | 1995-4484 1995-4492 |
| language | Russian |
| last_indexed | 2024-04-09T22:23:35Z |
| publishDate | 2016-12-01 |
| publisher | IMA PRESS LLC |
| record_format | Article |
| series | Научно-практическая ревматология |
| spelling | doaj.art-01f05f44882947169788408dc8a8fa5c2023-03-22T13:45:52ZrusIMA PRESS LLCНаучно-практическая ревматология1995-44841995-44922016-12-0154552752910.14412/1995-4484-2016-527-5292156BONE METABOLISM AND ITS REGULATION IN PATIENTS WITH ANKYLOSING SPONDYLITISO. V. Bugrova0K. A. Nagornova1N. E. Artemova2Orenburg State Medical UniversityOrenburg State Medical UniversityOrenburg State Medical UniversityOsteoporosis in ankylosing spondylitis (AS) may exacerbate pain and functional disorders and increases the risk of fractures. The mechanisms of its development in AS have not been adequately studied.Objective: to study bone mineral density (BMD) and its regulation in patients with AS.Subjects and methods. 70 patients (mean age, 43.2±9.2 years) with a documented diagnosis of AS (mean disease duration, 17.1±7.8 years) and a control group of 30 healthy individuals were examined. All the patients underwent estimation of BMD and the serum concentrations of osteocalcin, CrossLaps, and key regulators of osteoclastogenesis, such as osteoprotegerin (OPG) and a receptor activator of nuclear factor kappa-B ligand (RANKL) by an enzyme immunoassay. Results and discussion. In patients with AS, bone metabolism was characterized by a decrease in bone formation and by some increase in bone tissue degradation especially in high AS activity. These patients showed the elevated levels of the major blocker of osteoclastogenesis OPG and the OPG/RANKL ratio, which can cause the process of ossification characteristic of AS.https://rsp.mediar-press.net/rsp/article/view/2294osteoporosisankylosing spondylitisbone metabolismbone metabolism regulation |
| spellingShingle | O. V. Bugrova K. A. Nagornova N. E. Artemova BONE METABOLISM AND ITS REGULATION IN PATIENTS WITH ANKYLOSING SPONDYLITIS Научно-практическая ревматология osteoporosis ankylosing spondylitis bone metabolism bone metabolism regulation |
| title | BONE METABOLISM AND ITS REGULATION IN PATIENTS WITH ANKYLOSING SPONDYLITIS |
| title_full | BONE METABOLISM AND ITS REGULATION IN PATIENTS WITH ANKYLOSING SPONDYLITIS |
| title_fullStr | BONE METABOLISM AND ITS REGULATION IN PATIENTS WITH ANKYLOSING SPONDYLITIS |
| title_full_unstemmed | BONE METABOLISM AND ITS REGULATION IN PATIENTS WITH ANKYLOSING SPONDYLITIS |
| title_short | BONE METABOLISM AND ITS REGULATION IN PATIENTS WITH ANKYLOSING SPONDYLITIS |
| title_sort | bone metabolism and its regulation in patients with ankylosing spondylitis |
| topic | osteoporosis ankylosing spondylitis bone metabolism bone metabolism regulation |
| url | https://rsp.mediar-press.net/rsp/article/view/2294 |
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