Excess of heme induces tissue factor-dependent activation of coagulation in mice

An excess of free heme is present in the blood during many types of hemolytic anemia. This has been linked to organ damage caused by heme-mediated oxidative stress and vascular inflammation. We investigated the mechanism of heme-induced coagulation activation in vivo. Heme caused coagulation activat...

Бүрэн тодорхойлолт

Номзүйн дэлгэрэнгүй
Үндсэн зохиолчид: Erica M. Sparkenbaugh, Pichika Chantrathammachart, Shaobin Wang, Will Jonas, Daniel Kirchhofer, David Gailani, Andras Gruber, Raj Kasthuri, Nigel S. Key, Nigel Mackman, Rafal Pawlinski
Формат: Өгүүллэг
Хэл сонгох:English
Хэвлэсэн: Ferrata Storti Foundation 2015-03-01
Цуврал:Haematologica
Онлайн хандалт:https://haematologica.org/article/view/7301