Excess of heme induces tissue factor-dependent activation of coagulation in mice

An excess of free heme is present in the blood during many types of hemolytic anemia. This has been linked to organ damage caused by heme-mediated oxidative stress and vascular inflammation. We investigated the mechanism of heme-induced coagulation activation in vivo. Heme caused coagulation activat...

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Những tác giả chính: Erica M. Sparkenbaugh, Pichika Chantrathammachart, Shaobin Wang, Will Jonas, Daniel Kirchhofer, David Gailani, Andras Gruber, Raj Kasthuri, Nigel S. Key, Nigel Mackman, Rafal Pawlinski
Định dạng: Bài viết
Ngôn ngữ:English
Được phát hành: Ferrata Storti Foundation 2015-03-01
Loạt:Haematologica
Truy cập trực tuyến:https://haematologica.org/article/view/7301