18F-FP-CIT PET/CT in a case of probable sporadic Creutzfeldt-Jakob disease with parkinsonism as initial symptom
Creutzfeldt-Jakob disease (CJD) is a low-prevalence, fatal neurodegenerative disease. Parkinsonism as first symptom of CJD is rare. We present a case manifesting difficulty falling asleep as unspecific prodromal symptom and parkinsonism as initial symptom. The patient received positron emission tomo...
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2022-12-01
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| Series: | Prion |
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| Online Access: | https://www.tandfonline.com/doi/10.1080/19336896.2022.2093078 |
| _version_ | 1818519449557270528 |
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| author | Songhan Tang Xiaofeng Dou Ying Zhang |
| author_facet | Songhan Tang Xiaofeng Dou Ying Zhang |
| author_sort | Songhan Tang |
| collection | DOAJ |
| description | Creutzfeldt-Jakob disease (CJD) is a low-prevalence, fatal neurodegenerative disease. Parkinsonism as first symptom of CJD is rare. We present a case manifesting difficulty falling asleep as unspecific prodromal symptom and parkinsonism as initial symptom. The patient received positron emission tomography/computed tomography (PET/CT) of dopamine transporter (DAT) using 18 F-FP-CIT. The DAT-scan demonstrated presynaptic dopaminergic deficit in bilateral posterior putamen, which supports the hypothesis of nigrostriatal pathway dysfunction in CJD. |
| first_indexed | 2024-12-11T01:24:22Z |
| format | Article |
| id | doaj.art-01f0ea16b2504b1f991a4fe8a6cf948c |
| institution | Directory Open Access Journal |
| issn | 1933-6896 1933-690X |
| language | English |
| last_indexed | 2024-12-11T01:24:22Z |
| publishDate | 2022-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Prion |
| spelling | doaj.art-01f0ea16b2504b1f991a4fe8a6cf948c2022-12-22T01:25:35ZengTaylor & Francis GroupPrion1933-68961933-690X2022-12-01161919410.1080/19336896.2022.209307818F-FP-CIT PET/CT in a case of probable sporadic Creutzfeldt-Jakob disease with parkinsonism as initial symptomSonghan Tang0Xiaofeng Dou1Ying Zhang2Department of Nuclear Medicine, the Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, Zhejiang, ChinaDepartment of Nuclear Medicine, the Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, Zhejiang, ChinaDepartment of Nuclear Medicine, the Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, Zhejiang, ChinaCreutzfeldt-Jakob disease (CJD) is a low-prevalence, fatal neurodegenerative disease. Parkinsonism as first symptom of CJD is rare. We present a case manifesting difficulty falling asleep as unspecific prodromal symptom and parkinsonism as initial symptom. The patient received positron emission tomography/computed tomography (PET/CT) of dopamine transporter (DAT) using 18 F-FP-CIT. The DAT-scan demonstrated presynaptic dopaminergic deficit in bilateral posterior putamen, which supports the hypothesis of nigrostriatal pathway dysfunction in CJD.https://www.tandfonline.com/doi/10.1080/19336896.2022.2093078DAT PET/CTsporadic Creutzfeldt-Jakob diseaseparkinsonism |
| spellingShingle | Songhan Tang Xiaofeng Dou Ying Zhang 18F-FP-CIT PET/CT in a case of probable sporadic Creutzfeldt-Jakob disease with parkinsonism as initial symptom Prion DAT PET/CT sporadic Creutzfeldt-Jakob disease parkinsonism |
| title | 18F-FP-CIT PET/CT in a case of probable sporadic Creutzfeldt-Jakob disease with parkinsonism as initial symptom |
| title_full | 18F-FP-CIT PET/CT in a case of probable sporadic Creutzfeldt-Jakob disease with parkinsonism as initial symptom |
| title_fullStr | 18F-FP-CIT PET/CT in a case of probable sporadic Creutzfeldt-Jakob disease with parkinsonism as initial symptom |
| title_full_unstemmed | 18F-FP-CIT PET/CT in a case of probable sporadic Creutzfeldt-Jakob disease with parkinsonism as initial symptom |
| title_short | 18F-FP-CIT PET/CT in a case of probable sporadic Creutzfeldt-Jakob disease with parkinsonism as initial symptom |
| title_sort | 18f fp cit pet ct in a case of probable sporadic creutzfeldt jakob disease with parkinsonism as initial symptom |
| topic | DAT PET/CT sporadic Creutzfeldt-Jakob disease parkinsonism |
| url | https://www.tandfonline.com/doi/10.1080/19336896.2022.2093078 |
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