Clinical and laboratory characteristics of chronic hepatitis C on the early stages of development
Aim of the research – to assess the clinical and laboratory parameters in patients with chronic hepatitis C (CHC) on the early stages of development and their comparison with the level of galectin3. The study included 78 patients with oligosymptomatic course of the disease and minimal liver fibrosis...
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| Format: | Article |
| Language: | Russian |
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Academician I.P. Pavlov First St. Petersburg State Medical University
2016-12-01
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| Series: | Учёные записки Санкт-Петербургского государственного медицинского университета им. Акад. И.П. Павлова |
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| Online Access: | https://www.sci-notes.ru/jour/article/view/357 |
| _version_ | 1826560777174122496 |
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| author | N. S. Zhevnerova T. V. Antonova V. A. Kovaleva |
| author_facet | N. S. Zhevnerova T. V. Antonova V. A. Kovaleva |
| author_sort | N. S. Zhevnerova |
| collection | DOAJ |
| description | Aim of the research – to assess the clinical and laboratory parameters in patients with chronic hepatitis C (CHC) on the early stages of development and their comparison with the level of galectin3. The study included 78 patients with oligosymptomatic course of the disease and minimal liver fibrosis in the most cases. In the most patients with stages of the disease exceeding 8 years, viral load was over a million copies/ml. In 10 % of patients on the early stages of the disease, changes corresponding to severe liver fibrosis and cirrhosis F3 and F4 were detected. Moderate correlation of ALT activity, viral load and low severity with the duration of the disease was identified. There is a trend towards a higher level of galectin3 in a long course of CHC in comparison with earlier stages of its development, with significantly higher average level of galectin-3 in patients with minimal liver fibrosis (F0–F1) as compared to advanced stages, suggesting its importance in the launching and initial mechanisms of fibrogenesis. |
| first_indexed | 2024-03-12T03:41:14Z |
| format | Article |
| id | doaj.art-01f1bf198e7e4280a06ed96ae29266a8 |
| institution | Directory Open Access Journal |
| issn | 1607-4181 2541-8807 |
| language | Russian |
| last_indexed | 2025-03-14T09:21:40Z |
| publishDate | 2016-12-01 |
| publisher | Academician I.P. Pavlov First St. Petersburg State Medical University |
| record_format | Article |
| series | Учёные записки Санкт-Петербургского государственного медицинского университета им. Акад. И.П. Павлова |
| spelling | doaj.art-01f1bf198e7e4280a06ed96ae29266a82025-03-02T11:44:13ZrusAcademician I.P. Pavlov First St. Petersburg State Medical UniversityУчёные записки Санкт-Петербургского государственного медицинского университета им. Акад. И.П. Павлова1607-41812541-88072016-12-01234455910.24884/1607-4181-2016-23-4-45-59317Clinical and laboratory characteristics of chronic hepatitis C on the early stages of developmentN. S. Zhevnerova0T. V. Antonova1V. A. Kovaleva2Первый Санкт-Петербургский государственный медицинский университет имени академика И.П. ПавловаПервый Санкт-Петербургский государственный медицинский университет имени академика И.П. ПавловаПервый Санкт-Петербургский государственный медицинский университет имени академика И.П. ПавловаAim of the research – to assess the clinical and laboratory parameters in patients with chronic hepatitis C (CHC) on the early stages of development and their comparison with the level of galectin3. The study included 78 patients with oligosymptomatic course of the disease and minimal liver fibrosis in the most cases. In the most patients with stages of the disease exceeding 8 years, viral load was over a million copies/ml. In 10 % of patients on the early stages of the disease, changes corresponding to severe liver fibrosis and cirrhosis F3 and F4 were detected. Moderate correlation of ALT activity, viral load and low severity with the duration of the disease was identified. There is a trend towards a higher level of galectin3 in a long course of CHC in comparison with earlier stages of its development, with significantly higher average level of galectin-3 in patients with minimal liver fibrosis (F0–F1) as compared to advanced stages, suggesting its importance in the launching and initial mechanisms of fibrogenesis.https://www.sci-notes.ru/jour/article/view/357chronic hepatitis cgalectin-3liver fibrosis |
| spellingShingle | N. S. Zhevnerova T. V. Antonova V. A. Kovaleva Clinical and laboratory characteristics of chronic hepatitis C on the early stages of development Учёные записки Санкт-Петербургского государственного медицинского университета им. Акад. И.П. Павлова chronic hepatitis c galectin-3 liver fibrosis |
| title | Clinical and laboratory characteristics of chronic hepatitis C on the early stages of development |
| title_full | Clinical and laboratory characteristics of chronic hepatitis C on the early stages of development |
| title_fullStr | Clinical and laboratory characteristics of chronic hepatitis C on the early stages of development |
| title_full_unstemmed | Clinical and laboratory characteristics of chronic hepatitis C on the early stages of development |
| title_short | Clinical and laboratory characteristics of chronic hepatitis C on the early stages of development |
| title_sort | clinical and laboratory characteristics of chronic hepatitis c on the early stages of development |
| topic | chronic hepatitis c galectin-3 liver fibrosis |
| url | https://www.sci-notes.ru/jour/article/view/357 |
| work_keys_str_mv | AT nszhevnerova clinicalandlaboratorycharacteristicsofchronichepatitiscontheearlystagesofdevelopment AT tvantonova clinicalandlaboratorycharacteristicsofchronichepatitiscontheearlystagesofdevelopment AT vakovaleva clinicalandlaboratorycharacteristicsofchronichepatitiscontheearlystagesofdevelopment |