Spectrum of histopathological findings in pediatric renal biopsies; a five-year single center experience in Egypt
Introduction: Medical renal diseases stand as one of the major health problems in pediatric age group considering its morbidity/mortality and the subsequent management plans. Objectives: In this manuscript, the spectrum of histopathological patterns of medical nephropathic lesions in Egyptian pediat...
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| Format: | Article |
| Language: | English |
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Society of Diabetic Nephropathy Prevention
2023-03-01
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| Series: | Journal of Nephropathology |
| Subjects: | |
| Online Access: | https://nephropathol.com/PDF/jnp-12-e17247.pdf |
| _version_ | 1797828019780321280 |
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| author | Wael Mostafa Hamza Ahmed Fayed Amr Mohamed Shaker Mahmoud Mohamed El Nokeety |
| author_facet | Wael Mostafa Hamza Ahmed Fayed Amr Mohamed Shaker Mahmoud Mohamed El Nokeety |
| author_sort | Wael Mostafa Hamza |
| collection | DOAJ |
| description | Introduction: Medical renal diseases stand as one of the major health problems in pediatric age group considering its morbidity/mortality and the subsequent management plans. Objectives: In this manuscript, the spectrum of histopathological patterns of medical nephropathic lesions in Egyptian pediatric patients over duration of five years is reported with clinical indications. Patients and Methods: We conducted a retrospective study for analysis of our pathological reports of renal needle biopsies during the period from January 2014 until January 2019. One hundred and sixteen cases were included. Results: The most commonly encountered pediatric renal pathology was minimal change disease (27.59%), followed by congenital glomerular diseases (22.41%), focal segmental glomerulosclerosis (12.93%), and thrombotic microangiopathy (7.76%). The most common clinical indication for biopsy was nephrotic syndrome (37.07%) followed by impaired renal functions with elevated serum creatinine (21.55%). In addition, we report very rare histological findings in few cases including infantile nephropathic cystinosis, Barakat syndrome and C3 glomerulopathy. Conclusion: Minimal change disease and congenital glomerular diseases accounted for half of pediatric renal pathologies in the study population. The most common clinical indication for renal biopsy was nephrotic syndrome. Electron microscopic examination and genetic studies are mandatory for proper evaluation of pediatric nephropathies. |
| first_indexed | 2024-04-09T12:57:45Z |
| format | Article |
| id | doaj.art-01f1e1b4c239406aad8cf60552895dd6 |
| institution | Directory Open Access Journal |
| issn | 2251-8363 2251-8819 |
| language | English |
| last_indexed | 2024-04-09T12:57:45Z |
| publishDate | 2023-03-01 |
| publisher | Society of Diabetic Nephropathy Prevention |
| record_format | Article |
| series | Journal of Nephropathology |
| spelling | doaj.art-01f1e1b4c239406aad8cf60552895dd62023-05-13T10:58:18ZengSociety of Diabetic Nephropathy PreventionJournal of Nephropathology2251-83632251-88192023-03-01122e17247e1724710.34172/jnp.2022.17247jnp-17247Spectrum of histopathological findings in pediatric renal biopsies; a five-year single center experience in EgyptWael Mostafa Hamza0Ahmed Fayed1Amr Mohamed Shaker2Mahmoud Mohamed El Nokeety3Department of Pathology, Cairo University, Faculty of Medicine, Kasr Al Aini Hospital, Cairo, EgyptDepartment of Internal Medicine and Nephrology, Cairo University, Faculty of Medicine, Kasr Al Aini Hospital, Cairo, EgyptDepartment of Internal Medicine and Nephrology, Cairo University, Faculty of Medicine, Kasr Al Aini Hospital, Cairo, EgyptDepartment of Internal Medicine and Nephrology, Cairo University, Faculty of Medicine, Kasr Al Aini Hospital, Cairo, EgyptIntroduction: Medical renal diseases stand as one of the major health problems in pediatric age group considering its morbidity/mortality and the subsequent management plans. Objectives: In this manuscript, the spectrum of histopathological patterns of medical nephropathic lesions in Egyptian pediatric patients over duration of five years is reported with clinical indications. Patients and Methods: We conducted a retrospective study for analysis of our pathological reports of renal needle biopsies during the period from January 2014 until January 2019. One hundred and sixteen cases were included. Results: The most commonly encountered pediatric renal pathology was minimal change disease (27.59%), followed by congenital glomerular diseases (22.41%), focal segmental glomerulosclerosis (12.93%), and thrombotic microangiopathy (7.76%). The most common clinical indication for biopsy was nephrotic syndrome (37.07%) followed by impaired renal functions with elevated serum creatinine (21.55%). In addition, we report very rare histological findings in few cases including infantile nephropathic cystinosis, Barakat syndrome and C3 glomerulopathy. Conclusion: Minimal change disease and congenital glomerular diseases accounted for half of pediatric renal pathologies in the study population. The most common clinical indication for renal biopsy was nephrotic syndrome. Electron microscopic examination and genetic studies are mandatory for proper evaluation of pediatric nephropathies.https://nephropathol.com/PDF/jnp-12-e17247.pdfnephropathyhistopathologypediatric patientsrenal biopsy |
| spellingShingle | Wael Mostafa Hamza Ahmed Fayed Amr Mohamed Shaker Mahmoud Mohamed El Nokeety Spectrum of histopathological findings in pediatric renal biopsies; a five-year single center experience in Egypt Journal of Nephropathology nephropathy histopathology pediatric patients renal biopsy |
| title | Spectrum of histopathological findings in pediatric renal biopsies; a five-year single center experience in Egypt |
| title_full | Spectrum of histopathological findings in pediatric renal biopsies; a five-year single center experience in Egypt |
| title_fullStr | Spectrum of histopathological findings in pediatric renal biopsies; a five-year single center experience in Egypt |
| title_full_unstemmed | Spectrum of histopathological findings in pediatric renal biopsies; a five-year single center experience in Egypt |
| title_short | Spectrum of histopathological findings in pediatric renal biopsies; a five-year single center experience in Egypt |
| title_sort | spectrum of histopathological findings in pediatric renal biopsies a five year single center experience in egypt |
| topic | nephropathy histopathology pediatric patients renal biopsy |
| url | https://nephropathol.com/PDF/jnp-12-e17247.pdf |
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