Genetics of Parkinson’s Disease - A Clinical Perspective
Discovering genes following Medelian inheritance, such as autosomal dominant-synuclein and leucine-rich repeat kinase 2 gene, or autosomal recessive Parkin, P-TEN-induced putative kinase 1 gene and Daisuke-Junko 1 gene, has provided great insights into the pathogenesis of Parkinson’s disease (PD). G...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Korean Movement Disorder Society
2012-10-01
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| Series: | Journal of Movement Disorders |
| Subjects: | |
| Online Access: | http://e-jmd.org/upload/jmd-5-2-33-1.pdf |
| _version_ | 1797715956034699264 |
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| author | Sang-Myung Cheon Lilian Chan Daniel Kam Yin Chan Jae Woo Kim |
| author_facet | Sang-Myung Cheon Lilian Chan Daniel Kam Yin Chan Jae Woo Kim |
| author_sort | Sang-Myung Cheon |
| collection | DOAJ |
| description | Discovering genes following Medelian inheritance, such as autosomal dominant-synuclein and leucine-rich repeat kinase 2 gene, or autosomal recessive Parkin, P-TEN-induced putative kinase 1 gene and Daisuke-Junko 1 gene, has provided great insights into the pathogenesis of Parkinson’s disease (PD). Genes found to be associated with PD through investigating genetic polymorphisms or via the whole genome association studies suggest that such genes could also contribute to an increased risk of PD in the general population. Some environmental factors have been found to be associated with genetic factors in at-risk patients, further implicating the role of gene-environment interactions in sporadic PD. There may be confusion for clinicians facing rapid progresses of genetic understanding in PD. After a brief review of PD genetics, we will discuss the insight of new genetic discoveries to clinicians, the implications of ethnic differences in PD genetics and the role of genetic testing for general clinicians managing PD patients. |
| first_indexed | 2024-03-12T08:15:26Z |
| format | Article |
| id | doaj.art-01f26ecfb14e421ea8ad933b5095b032 |
| institution | Directory Open Access Journal |
| issn | 2005-940X 2093-4939 |
| language | English |
| last_indexed | 2024-03-12T08:15:26Z |
| publishDate | 2012-10-01 |
| publisher | Korean Movement Disorder Society |
| record_format | Article |
| series | Journal of Movement Disorders |
| spelling | doaj.art-01f26ecfb14e421ea8ad933b5095b0322023-09-02T18:56:15ZengKorean Movement Disorder SocietyJournal of Movement Disorders2005-940X2093-49392012-10-0152334110.14802/jmd.1200916Genetics of Parkinson’s Disease - A Clinical PerspectiveSang-Myung CheonLilian ChanDaniel Kam Yin ChanJae Woo KimDiscovering genes following Medelian inheritance, such as autosomal dominant-synuclein and leucine-rich repeat kinase 2 gene, or autosomal recessive Parkin, P-TEN-induced putative kinase 1 gene and Daisuke-Junko 1 gene, has provided great insights into the pathogenesis of Parkinson’s disease (PD). Genes found to be associated with PD through investigating genetic polymorphisms or via the whole genome association studies suggest that such genes could also contribute to an increased risk of PD in the general population. Some environmental factors have been found to be associated with genetic factors in at-risk patients, further implicating the role of gene-environment interactions in sporadic PD. There may be confusion for clinicians facing rapid progresses of genetic understanding in PD. After a brief review of PD genetics, we will discuss the insight of new genetic discoveries to clinicians, the implications of ethnic differences in PD genetics and the role of genetic testing for general clinicians managing PD patients.http://e-jmd.org/upload/jmd-5-2-33-1.pdfParkinson’s diseaseGenetics |
| spellingShingle | Sang-Myung Cheon Lilian Chan Daniel Kam Yin Chan Jae Woo Kim Genetics of Parkinson’s Disease - A Clinical Perspective Journal of Movement Disorders Parkinson’s disease Genetics |
| title | Genetics of Parkinson’s Disease - A Clinical Perspective |
| title_full | Genetics of Parkinson’s Disease - A Clinical Perspective |
| title_fullStr | Genetics of Parkinson’s Disease - A Clinical Perspective |
| title_full_unstemmed | Genetics of Parkinson’s Disease - A Clinical Perspective |
| title_short | Genetics of Parkinson’s Disease - A Clinical Perspective |
| title_sort | genetics of parkinson s disease a clinical perspective |
| topic | Parkinson’s disease Genetics |
| url | http://e-jmd.org/upload/jmd-5-2-33-1.pdf |
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